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Identification of Alcohol Use Prior to Major Cancer Surgery : Timeline Follow Back Interview Compared to Four Other Markers

Nicklasson, Johanna ; Sjödell, Moa ; Tønnesen, Hanne LU ; Lauridsen, Susanne Vahr and Rasmussen, Mette LU orcid (2024) In Cancers 16(12). p.1-10
Abstract

BACKGROUND: The postoperative complication rate is 30-64% among patients undergoing muscle-invasive and recurrent high-risk non-muscle-invasive bladder cancer surgery. Preoperative risky alcohol use increases the risk. The aim was to evaluate the accuracy of markers for identifying preoperative risky alcohol.

METHODS: Diagnostic test sub-study of a randomized controlled trial (STOP-OP trial), based on a cohort of 94 patients scheduled for major bladder cancer surgery. Identification of risky alcohol use using Timeline Follow Back interviews (TLFB) were compared to the AUDIT-C questionnaire and three biomarkers: carbohydrate-deficient transferrin in plasma (P-CDT), phosphatidyl-ethanol in blood (B-PEth), and ethyl glucuronide in... (More)

BACKGROUND: The postoperative complication rate is 30-64% among patients undergoing muscle-invasive and recurrent high-risk non-muscle-invasive bladder cancer surgery. Preoperative risky alcohol use increases the risk. The aim was to evaluate the accuracy of markers for identifying preoperative risky alcohol.

METHODS: Diagnostic test sub-study of a randomized controlled trial (STOP-OP trial), based on a cohort of 94 patients scheduled for major bladder cancer surgery. Identification of risky alcohol use using Timeline Follow Back interviews (TLFB) were compared to the AUDIT-C questionnaire and three biomarkers: carbohydrate-deficient transferrin in plasma (P-CDT), phosphatidyl-ethanol in blood (B-PEth), and ethyl glucuronide in urine (U-EtG).

RESULTS: The correlation between TLFB and AUDIT-C was strong (ρ = 0.75), while it was moderate between TLFB and the biomarkers (ρ = 0.55-0.65). Overall, sensitivity ranged from 56 to 82% and specificity from 38 to 100%. B-PEth showed the lowest sensitivity at 56%, but the highest specificity of 100%. All tests had high positive predictive values (79-100%), but low negative predictive values (42-55%).

CONCLUSIONS: Despite high positive predictive values, negative predictive values were weak compared to TLFB. For now, TLFB interviews seem preferable for preoperative identification of risky alcohol use.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cancers
volume
16
issue
12
article number
2261
pages
1 - 10
publisher
MDPI AG
external identifiers
  • pmid:38927966
ISSN
2072-6694
DOI
10.3390/cancers16122261
language
English
LU publication?
yes
id
e02dca50-3ef5-4a48-9ccb-4b2c1db41d05
date added to LUP
2024-06-27 16:06:14
date last changed
2024-07-01 08:36:11
@article{e02dca50-3ef5-4a48-9ccb-4b2c1db41d05,
  abstract     = {{<p>BACKGROUND: The postoperative complication rate is 30-64% among patients undergoing muscle-invasive and recurrent high-risk non-muscle-invasive bladder cancer surgery. Preoperative risky alcohol use increases the risk. The aim was to evaluate the accuracy of markers for identifying preoperative risky alcohol.</p><p>METHODS: Diagnostic test sub-study of a randomized controlled trial (STOP-OP trial), based on a cohort of 94 patients scheduled for major bladder cancer surgery. Identification of risky alcohol use using Timeline Follow Back interviews (TLFB) were compared to the AUDIT-C questionnaire and three biomarkers: carbohydrate-deficient transferrin in plasma (P-CDT), phosphatidyl-ethanol in blood (B-PEth), and ethyl glucuronide in urine (U-EtG).</p><p>RESULTS: The correlation between TLFB and AUDIT-C was strong (ρ = 0.75), while it was moderate between TLFB and the biomarkers (ρ = 0.55-0.65). Overall, sensitivity ranged from 56 to 82% and specificity from 38 to 100%. B-PEth showed the lowest sensitivity at 56%, but the highest specificity of 100%. All tests had high positive predictive values (79-100%), but low negative predictive values (42-55%).</p><p>CONCLUSIONS: Despite high positive predictive values, negative predictive values were weak compared to TLFB. For now, TLFB interviews seem preferable for preoperative identification of risky alcohol use.</p>}},
  author       = {{Nicklasson, Johanna and Sjödell, Moa and Tønnesen, Hanne and Lauridsen, Susanne Vahr and Rasmussen, Mette}},
  issn         = {{2072-6694}},
  language     = {{eng}},
  month        = {{06}},
  number       = {{12}},
  pages        = {{1--10}},
  publisher    = {{MDPI AG}},
  series       = {{Cancers}},
  title        = {{Identification of Alcohol Use Prior to Major Cancer Surgery : Timeline Follow Back Interview Compared to Four Other Markers}},
  url          = {{http://dx.doi.org/10.3390/cancers16122261}},
  doi          = {{10.3390/cancers16122261}},
  volume       = {{16}},
  year         = {{2024}},
}