Identification of Alcohol Use Prior to Major Cancer Surgery : Timeline Follow Back Interview Compared to Four Other Markers
(2024) In Cancers 16(12). p.1-10- Abstract
BACKGROUND: The postoperative complication rate is 30-64% among patients undergoing muscle-invasive and recurrent high-risk non-muscle-invasive bladder cancer surgery. Preoperative risky alcohol use increases the risk. The aim was to evaluate the accuracy of markers for identifying preoperative risky alcohol.
METHODS: Diagnostic test sub-study of a randomized controlled trial (STOP-OP trial), based on a cohort of 94 patients scheduled for major bladder cancer surgery. Identification of risky alcohol use using Timeline Follow Back interviews (TLFB) were compared to the AUDIT-C questionnaire and three biomarkers: carbohydrate-deficient transferrin in plasma (P-CDT), phosphatidyl-ethanol in blood (B-PEth), and ethyl glucuronide in... (More)
BACKGROUND: The postoperative complication rate is 30-64% among patients undergoing muscle-invasive and recurrent high-risk non-muscle-invasive bladder cancer surgery. Preoperative risky alcohol use increases the risk. The aim was to evaluate the accuracy of markers for identifying preoperative risky alcohol.
METHODS: Diagnostic test sub-study of a randomized controlled trial (STOP-OP trial), based on a cohort of 94 patients scheduled for major bladder cancer surgery. Identification of risky alcohol use using Timeline Follow Back interviews (TLFB) were compared to the AUDIT-C questionnaire and three biomarkers: carbohydrate-deficient transferrin in plasma (P-CDT), phosphatidyl-ethanol in blood (B-PEth), and ethyl glucuronide in urine (U-EtG).
RESULTS: The correlation between TLFB and AUDIT-C was strong (ρ = 0.75), while it was moderate between TLFB and the biomarkers (ρ = 0.55-0.65). Overall, sensitivity ranged from 56 to 82% and specificity from 38 to 100%. B-PEth showed the lowest sensitivity at 56%, but the highest specificity of 100%. All tests had high positive predictive values (79-100%), but low negative predictive values (42-55%).
CONCLUSIONS: Despite high positive predictive values, negative predictive values were weak compared to TLFB. For now, TLFB interviews seem preferable for preoperative identification of risky alcohol use.
(Less)
- author
- Nicklasson, Johanna
; Sjödell, Moa
; Tønnesen, Hanne
LU
; Lauridsen, Susanne Vahr
and Rasmussen, Mette
LU
- organization
- publishing date
- 2024-06-18
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Cancers
- volume
- 16
- issue
- 12
- article number
- 2261
- pages
- 1 - 10
- publisher
- MDPI AG
- external identifiers
-
- pmid:38927966
- ISSN
- 2072-6694
- DOI
- 10.3390/cancers16122261
- language
- English
- LU publication?
- yes
- id
- e02dca50-3ef5-4a48-9ccb-4b2c1db41d05
- date added to LUP
- 2024-06-27 16:06:14
- date last changed
- 2024-07-01 08:36:11
@article{e02dca50-3ef5-4a48-9ccb-4b2c1db41d05, abstract = {{<p>BACKGROUND: The postoperative complication rate is 30-64% among patients undergoing muscle-invasive and recurrent high-risk non-muscle-invasive bladder cancer surgery. Preoperative risky alcohol use increases the risk. The aim was to evaluate the accuracy of markers for identifying preoperative risky alcohol.</p><p>METHODS: Diagnostic test sub-study of a randomized controlled trial (STOP-OP trial), based on a cohort of 94 patients scheduled for major bladder cancer surgery. Identification of risky alcohol use using Timeline Follow Back interviews (TLFB) were compared to the AUDIT-C questionnaire and three biomarkers: carbohydrate-deficient transferrin in plasma (P-CDT), phosphatidyl-ethanol in blood (B-PEth), and ethyl glucuronide in urine (U-EtG).</p><p>RESULTS: The correlation between TLFB and AUDIT-C was strong (ρ = 0.75), while it was moderate between TLFB and the biomarkers (ρ = 0.55-0.65). Overall, sensitivity ranged from 56 to 82% and specificity from 38 to 100%. B-PEth showed the lowest sensitivity at 56%, but the highest specificity of 100%. All tests had high positive predictive values (79-100%), but low negative predictive values (42-55%).</p><p>CONCLUSIONS: Despite high positive predictive values, negative predictive values were weak compared to TLFB. For now, TLFB interviews seem preferable for preoperative identification of risky alcohol use.</p>}}, author = {{Nicklasson, Johanna and Sjödell, Moa and Tønnesen, Hanne and Lauridsen, Susanne Vahr and Rasmussen, Mette}}, issn = {{2072-6694}}, language = {{eng}}, month = {{06}}, number = {{12}}, pages = {{1--10}}, publisher = {{MDPI AG}}, series = {{Cancers}}, title = {{Identification of Alcohol Use Prior to Major Cancer Surgery : Timeline Follow Back Interview Compared to Four Other Markers}}, url = {{http://dx.doi.org/10.3390/cancers16122261}}, doi = {{10.3390/cancers16122261}}, volume = {{16}}, year = {{2024}}, }