Circulating Midregional Proadrenomedullin and Risk of Incident Abdominal Aortic Aneurysm : A Prospective Longitudinal Cohort Study
(2018) In Angiology 69(4). p.333-338- Abstract
Prospective clinical plasma biomarker studies in abdominal aortic aneurysm (AAA) pathogenesis have been hampered by the need for very large cohorts and long follow-up time. The main aim of the present study was to evaluate the association of adrenomedullin, a cardiovascular (CV) stress marker, and incident AAA risk. Prospective longitudinal cohort of middle-aged individuals from the CV cohort of the Malmö Diet and Cancer Study (n = 5551; 1991-1994) was assessed. Plasma concentrations of midregional proadrenomedullin (MR-proADM), C-reactive protein (CRP), and conventional risk factors were measured at baseline. Incidence of AAA was studied up to December 31, 2013. Cumulative incidence of AAA was 1.5% (men 2.9%, women 0.5%). Mean age of... (More)
Prospective clinical plasma biomarker studies in abdominal aortic aneurysm (AAA) pathogenesis have been hampered by the need for very large cohorts and long follow-up time. The main aim of the present study was to evaluate the association of adrenomedullin, a cardiovascular (CV) stress marker, and incident AAA risk. Prospective longitudinal cohort of middle-aged individuals from the CV cohort of the Malmö Diet and Cancer Study (n = 5551; 1991-1994) was assessed. Plasma concentrations of midregional proadrenomedullin (MR-proADM), C-reactive protein (CRP), and conventional risk factors were measured at baseline. Incidence of AAA was studied up to December 31, 2013. Cumulative incidence of AAA was 1.5% (men 2.9%, women 0.5%). Mean age of individuals with incident AAA was 59.7 years at study entry, and AAA was diagnosed on average 14 years later. Adjusting for age, gender, smoking, body mass index, hypertension, diabetes mellitus, and CRP, MR-proADM (hazard ratio: 1.28; 95% confidence interval: 1.01-1.62) was independently associated with incident AAA. The plasma biomarker MR-proADM seems to be a marker of AAA risk, implying that AAA development may be driven by long-standing CV stress on the aortic wall.
(Less)
- author
- Acosta, Stefan
LU
; Gottsäter, Anders LU ; Engström, Gunnar LU ; Melander, Olle LU
; Zarrouk, Moncef LU ; Nilsson, Peter M LU and Smith, Gustav LU
- organization
-
- Vascular Diseases - Clinical Research (research group)
- Cardiovascular Research - Epidemiology (research group)
- Cardiovascular Research - Hypertension (research group)
- Internal Medicine - Epidemiology (research group)
- Cardiology
- Cardiovascular Epigenetics (research group)
- Molecular Epidemiology and Cardiology (research group)
- Heart Failure and Mechanical Support (research group)
- EXODIAB: Excellence of Diabetes Research in Sweden
- EpiHealth: Epidemiology for Health
- publishing date
- 2018-04-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Angiology
- volume
- 69
- issue
- 4
- pages
- 333 - 338
- publisher
- SAGE Publications
- external identifiers
-
- pmid:28766358
- scopus:85042753945
- ISSN
- 0003-3197
- DOI
- 10.1177/0003319717723255
- language
- English
- LU publication?
- yes
- id
- e39837a3-510f-49b4-bb4c-62fedf7900d2
- date added to LUP
- 2017-09-05 08:11:14
- date last changed
- 2024-08-06 04:28:00
@article{e39837a3-510f-49b4-bb4c-62fedf7900d2, abstract = {{<p>Prospective clinical plasma biomarker studies in abdominal aortic aneurysm (AAA) pathogenesis have been hampered by the need for very large cohorts and long follow-up time. The main aim of the present study was to evaluate the association of adrenomedullin, a cardiovascular (CV) stress marker, and incident AAA risk. Prospective longitudinal cohort of middle-aged individuals from the CV cohort of the Malmö Diet and Cancer Study (n = 5551; 1991-1994) was assessed. Plasma concentrations of midregional proadrenomedullin (MR-proADM), C-reactive protein (CRP), and conventional risk factors were measured at baseline. Incidence of AAA was studied up to December 31, 2013. Cumulative incidence of AAA was 1.5% (men 2.9%, women 0.5%). Mean age of individuals with incident AAA was 59.7 years at study entry, and AAA was diagnosed on average 14 years later. Adjusting for age, gender, smoking, body mass index, hypertension, diabetes mellitus, and CRP, MR-proADM (hazard ratio: 1.28; 95% confidence interval: 1.01-1.62) was independently associated with incident AAA. The plasma biomarker MR-proADM seems to be a marker of AAA risk, implying that AAA development may be driven by long-standing CV stress on the aortic wall.</p>}}, author = {{Acosta, Stefan and Gottsäter, Anders and Engström, Gunnar and Melander, Olle and Zarrouk, Moncef and Nilsson, Peter M and Smith, Gustav}}, issn = {{0003-3197}}, language = {{eng}}, month = {{04}}, number = {{4}}, pages = {{333--338}}, publisher = {{SAGE Publications}}, series = {{Angiology}}, title = {{Circulating Midregional Proadrenomedullin and Risk of Incident Abdominal Aortic Aneurysm : A Prospective Longitudinal Cohort Study}}, url = {{http://dx.doi.org/10.1177/0003319717723255}}, doi = {{10.1177/0003319717723255}}, volume = {{69}}, year = {{2018}}, }