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Prenatal phthalate exposure and early childhood wheeze in the SELMA study

Preece, Anna Sofia ; Knutz, Malin ; Lindh, Christian H. LU orcid ; Bornehag, Carl Gustaf LU and Shu, Huan (2022) In Journal of Exposure Science and Environmental Epidemiology 32(2). p.303-311
Abstract

Background: Prenatal maternal phthalate exposure has been associated with wheeze and asthma in children, but results are inconclusive. Previous studies typically assessed exposure in late pregnancy, included only a small number of old phthalates, and assessed outcomes in children aged 5 years or older. Objective: We explored associations between 1st trimester prenatal maternal exposure to a wider range of phthalates and wheeze in early childhood. Methods: First trimester concentrations of 14 metabolites from 8 phthalates and one alternative plasticizer were quantified in first-morning void urine from 1148 mothers in the Swedish SELMA study. Associations between log-transformed metabolite concentrations and parental reported ever wheeze... (More)

Background: Prenatal maternal phthalate exposure has been associated with wheeze and asthma in children, but results are inconclusive. Previous studies typically assessed exposure in late pregnancy, included only a small number of old phthalates, and assessed outcomes in children aged 5 years or older. Objective: We explored associations between 1st trimester prenatal maternal exposure to a wider range of phthalates and wheeze in early childhood. Methods: First trimester concentrations of 14 metabolites from 8 phthalates and one alternative plasticizer were quantified in first-morning void urine from 1148 mothers in the Swedish SELMA study. Associations between log-transformed metabolite concentrations and parental reported ever wheeze among 24-month-old children were investigated with logistic regression models adjusted for parental asthma/rhinitis, sex of child, maternal education, smoking, and creatinine. Results: Metabolites of replacement phthalates di-iso-decyl phthalate (DiDP) and di-2-propylheptyl phthalate (DPHP) were associated with increased risk for wheeze (aOR 1.47, 95% CI 1.08-2.01 and aOR 1.49, 95% CI 1.04–2.15, respectively). The associations with DiDP and DPHP were stronger among children whose parents did not have asthma or rhinitis. In this group, wheeze was also associated with metabolites of butyl-benzyl phthalate (BBzP) and di-iso-nonyl phthalate (DiNP). Significance: Maternal phthalate exposure during early pregnancy may be a risk factor for wheeze in early childhood, especially among children whose parents do not have asthma or rhinitis symptoms.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Children’s health, Endocrine disruption, Plasticizer, Pregnancy, Respiratory
in
Journal of Exposure Science and Environmental Epidemiology
volume
32
issue
2
pages
303 - 311
publisher
Nature Publishing Group
external identifiers
  • pmid:34475495
  • scopus:85114619396
ISSN
1559-0631
DOI
10.1038/s41370-021-00382-w
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.
id
e5a8d143-2161-4a1d-bc9a-8927589e3f26
date added to LUP
2021-10-18 15:41:58
date last changed
2024-06-29 19:20:34
@article{e5a8d143-2161-4a1d-bc9a-8927589e3f26,
  abstract     = {{<p>Background: Prenatal maternal phthalate exposure has been associated with wheeze and asthma in children, but results are inconclusive. Previous studies typically assessed exposure in late pregnancy, included only a small number of old phthalates, and assessed outcomes in children aged 5 years or older. Objective: We explored associations between 1st trimester prenatal maternal exposure to a wider range of phthalates and wheeze in early childhood. Methods: First trimester concentrations of 14 metabolites from 8 phthalates and one alternative plasticizer were quantified in first-morning void urine from 1148 mothers in the Swedish SELMA study. Associations between log-transformed metabolite concentrations and parental reported ever wheeze among 24-month-old children were investigated with logistic regression models adjusted for parental asthma/rhinitis, sex of child, maternal education, smoking, and creatinine. Results: Metabolites of replacement phthalates di-iso-decyl phthalate (DiDP) and di-2-propylheptyl phthalate (DPHP) were associated with increased risk for wheeze (aOR 1.47, 95% CI 1.08-2.01 and aOR 1.49, 95% CI 1.04–2.15, respectively). The associations with DiDP and DPHP were stronger among children whose parents did not have asthma or rhinitis. In this group, wheeze was also associated with metabolites of butyl-benzyl phthalate (BBzP) and di-iso-nonyl phthalate (DiNP). Significance: Maternal phthalate exposure during early pregnancy may be a risk factor for wheeze in early childhood, especially among children whose parents do not have asthma or rhinitis symptoms.</p>}},
  author       = {{Preece, Anna Sofia and Knutz, Malin and Lindh, Christian H. and Bornehag, Carl Gustaf and Shu, Huan}},
  issn         = {{1559-0631}},
  keywords     = {{Children’s health; Endocrine disruption; Plasticizer; Pregnancy; Respiratory}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{303--311}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Journal of Exposure Science and Environmental Epidemiology}},
  title        = {{Prenatal phthalate exposure and early childhood wheeze in the SELMA study}},
  url          = {{http://dx.doi.org/10.1038/s41370-021-00382-w}},
  doi          = {{10.1038/s41370-021-00382-w}},
  volume       = {{32}},
  year         = {{2022}},
}