Hypoxia and hypoxia-inducible factors in neuroblastoma
Påhlman, Sven LU and Mohlin, Sofie LU
(2018)
In Cell and Tissue Research
372(2).
p.269-275
- Abstract
Hypoxia (i.e., low oxygen levels) is a known feature of aggressive tumors. Cells, including tumor cells, respond to conditions of insufficient oxygen by activating a transcriptional program mainly driven by hypoxia-inducible factors (HIF)-1 and HIF-2. Both HIF-1α and HIF-2α expression levels have been shown to correlate to patient outcome in various tumor forms and in neuroblastoma, a solid childhood tumor of the sympathetic nervous system, in particular, HIF-2α marks a subpopulation of immature neural crest-like perivascularly located cells and associates with aggressive disease and distant metastasis. It has for long been recognized that the HIF-α subunits are oxygen-dependently regulated at the post-translational level, via... (More)
Hypoxia (i.e., low oxygen levels) is a known feature of aggressive tumors. Cells, including tumor cells, respond to conditions of insufficient oxygen by activating a transcriptional program mainly driven by hypoxia-inducible factors (HIF)-1 and HIF-2. Both HIF-1α and HIF-2α expression levels have been shown to correlate to patient outcome in various tumor forms and in neuroblastoma, a solid childhood tumor of the sympathetic nervous system, in particular, HIF-2α marks a subpopulation of immature neural crest-like perivascularly located cells and associates with aggressive disease and distant metastasis. It has for long been recognized that the HIF-α subunits are oxygen-dependently regulated at the post-translational level, via ubiquitination and proteasomal degradation. Evidence of oxygen-independent mechanisms of regulation, transcriptional control of EPAS1/HIF2A and possible cytoplasmic activities of HIF-2α has also emerged during recent years. In this review, we discuss these non-conventional actions of HIF-2α, its putative role as a therapeutic target and the constraints it carries, as well as the importance of HIF-2 activity in a vascularized setting, the so-called pseudo-hypoxic state.
(Less)
- author
- Påhlman, Sven
LU
and Mohlin, Sofie
LU
- organization
- publishing date
- 2018
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Cancer stem cell, Hypoxia, Hypoxia-inducible factor, Neuroblastoma, Vascularization
- in
- Cell and Tissue Research
- volume
- 372
- issue
- 2
- pages
- 269 - 275
- publisher
- Springer
- external identifiers
-
- pmid:29032465
- scopus:85031409456
- ISSN
- 0302-766X
- DOI
- 10.1007/s00441-017-2701-1
- language
- English
- LU publication?
- yes
- id
- e8afff90-271f-4679-918d-1d698390a1b8
- date added to LUP
- 2017-11-20 11:26:39
- date last changed
- 2024-03-01 03:29:01
@article{e8afff90-271f-4679-918d-1d698390a1b8,
abstract = {{<p>Hypoxia (i.e., low oxygen levels) is a known feature of aggressive tumors. Cells, including tumor cells, respond to conditions of insufficient oxygen by activating a transcriptional program mainly driven by hypoxia-inducible factors (HIF)-1 and HIF-2. Both HIF-1α and HIF-2α expression levels have been shown to correlate to patient outcome in various tumor forms and in neuroblastoma, a solid childhood tumor of the sympathetic nervous system, in particular, HIF-2α marks a subpopulation of immature neural crest-like perivascularly located cells and associates with aggressive disease and distant metastasis. It has for long been recognized that the HIF-α subunits are oxygen-dependently regulated at the post-translational level, via ubiquitination and proteasomal degradation. Evidence of oxygen-independent mechanisms of regulation, transcriptional control of EPAS1/HIF2A and possible cytoplasmic activities of HIF-2α has also emerged during recent years. In this review, we discuss these non-conventional actions of HIF-2α, its putative role as a therapeutic target and the constraints it carries, as well as the importance of HIF-2 activity in a vascularized setting, the so-called pseudo-hypoxic state.</p>}},
author = {{Påhlman, Sven and Mohlin, Sofie}},
issn = {{0302-766X}},
keywords = {{Cancer stem cell; Hypoxia; Hypoxia-inducible factor; Neuroblastoma; Vascularization}},
language = {{eng}},
number = {{2}},
pages = {{269--275}},
publisher = {{Springer}},
series = {{Cell and Tissue Research}},
title = {{Hypoxia and hypoxia-inducible factors in neuroblastoma}},
url = {{http://dx.doi.org/10.1007/s00441-017-2701-1}},
doi = {{10.1007/s00441-017-2701-1}},
volume = {{372}},
year = {{2018}},
}