Structural brain correlates of sustained attention in healthy ageing: Cross-sectional findings from the LEISURE study
Treacy, Ciara ; Campbell, Alicia J. LU
; Anijärv, Toomas Erik
LU
; Lagopoulos, Jim
; Hermens, Daniel F.
; Andrews, Sophie C.
and Levenstein, Jacob M.
(2024)
In Neurobiology of Aging
144(December 2024).
p.93-103
- Abstract
- Sustained attention is important for maintaining cognitive function and autonomy during ageing, yet older people often show reductions in this domain. The role of the underlying neurobiology is not yet well understood, with most neuroimaging studies primarily focused on fMRI. Here, we utilise sMRI to investigate the relationships between age, structural brain volumes and sustained attention performance. Eighty-nine healthy older adults (50–84 years, Mage 65.5 (SD=8.4) years, 74 f) underwent MRI brain scanning and completed two sustained attention tasks: a rapid visual information processing (RVP) task and sustained attention to response task (SART). Independent hierarchical linear regressions demonstrated that greater volumes of white... (More)
- Sustained attention is important for maintaining cognitive function and autonomy during ageing, yet older people often show reductions in this domain. The role of the underlying neurobiology is not yet well understood, with most neuroimaging studies primarily focused on fMRI. Here, we utilise sMRI to investigate the relationships between age, structural brain volumes and sustained attention performance. Eighty-nine healthy older adults (50–84 years, Mage 65.5 (SD=8.4) years, 74 f) underwent MRI brain scanning and completed two sustained attention tasks: a rapid visual information processing (RVP) task and sustained attention to response task (SART). Independent hierarchical linear regressions demonstrated that greater volumes of white matter hyperintensities (WMH) were associated with worse RVP_A’ performance, whereas greater grey matter volumes were associated with better RVP_A’ performance. Further, greater cerebral white matter volumes were associated with better SART_d’ performance. Importantly, mediation analyses revealed that both grey and white matter volumes completely mediated the relationship between ageing and sustained attention. These results explain disparate attentional findings in older adults, highlighting the intervening role of brain structure.
(Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/e8f23223-b4b4-4326-9913-7e39a3d4482c
- author
- Treacy, Ciara
; Campbell, Alicia J.
LU
; Anijärv, Toomas Erik
LU
; Lagopoulos, Jim
; Hermens, Daniel F.
; Andrews, Sophie C.
and Levenstein, Jacob M.
- organization
- publishing date
- 2024
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Neurobiology of Aging
- volume
- 144
- issue
- December 2024
- pages
- 93 - 103
- publisher
- Elsevier
- external identifiers
-
- pmid:39298870
- scopus:85204212406
- ISSN
- 1558-1497
- DOI
- 10.1016/j.neurobiolaging.2024.09.010
- language
- English
- LU publication?
- yes
- id
- e8f23223-b4b4-4326-9913-7e39a3d4482c
- date added to LUP
- 2024-11-12 12:16:26
- date last changed
- 2025-06-25 23:13:58
@article{e8f23223-b4b4-4326-9913-7e39a3d4482c,
abstract = {{Sustained attention is important for maintaining cognitive function and autonomy during ageing, yet older people often show reductions in this domain. The role of the underlying neurobiology is not yet well understood, with most neuroimaging studies primarily focused on fMRI. Here, we utilise sMRI to investigate the relationships between age, structural brain volumes and sustained attention performance. Eighty-nine healthy older adults (50–84 years, Mage 65.5 (SD=8.4) years, 74 f) underwent MRI brain scanning and completed two sustained attention tasks: a rapid visual information processing (RVP) task and sustained attention to response task (SART). Independent hierarchical linear regressions demonstrated that greater volumes of white matter hyperintensities (WMH) were associated with worse RVP_A’ performance, whereas greater grey matter volumes were associated with better RVP_A’ performance. Further, greater cerebral white matter volumes were associated with better SART_d’ performance. Importantly, mediation analyses revealed that both grey and white matter volumes completely mediated the relationship between ageing and sustained attention. These results explain disparate attentional findings in older adults, highlighting the intervening role of brain structure.<br/>}},
author = {{Treacy, Ciara and Campbell, Alicia J. and Anijärv, Toomas Erik and Lagopoulos, Jim and Hermens, Daniel F. and Andrews, Sophie C. and Levenstein, Jacob M.}},
issn = {{1558-1497}},
language = {{eng}},
number = {{December 2024}},
pages = {{93--103}},
publisher = {{Elsevier}},
series = {{Neurobiology of Aging}},
title = {{Structural brain correlates of sustained attention in healthy ageing: Cross-sectional findings from the LEISURE study}},
url = {{http://dx.doi.org/10.1016/j.neurobiolaging.2024.09.010}},
doi = {{10.1016/j.neurobiolaging.2024.09.010}},
volume = {{144}},
year = {{2024}},
}