Effects of delayed cord clamping on neurodevelopment and infection at four months of age : A randomised trial
(2013) In Acta Paediatrica, International Journal of Paediatrics 102(5). p.525-531- Abstract
Aim To investigate the effect that delayed and early umbilical cord clamping have on neurodevelopment, immunoglobulin G (IgG) and symptoms of infection during the first 4 months of life. Methods Full-term infants (n = 382) were randomised to delayed (≥180 sec) or early cord clamping (≤10 sec). The Ages and Stages Questionnaire (ASQ) was used to assess neurodevelopment at 4 months. Immunoglobulin G was measured at birth, 2-3 days and 4 months. Parents recorded any symptoms indicating infection during the first 4 months of life. Results The total scores from the ASQ did not differ between groups. However, the delayed cord clamping (DCC) group had a higher mean (SD) score in the problem-solving domain [55.3 (7.2) vs. 53.5 (8.2), p = 0.03]... (More)
Aim To investigate the effect that delayed and early umbilical cord clamping have on neurodevelopment, immunoglobulin G (IgG) and symptoms of infection during the first 4 months of life. Methods Full-term infants (n = 382) were randomised to delayed (≥180 sec) or early cord clamping (≤10 sec). The Ages and Stages Questionnaire (ASQ) was used to assess neurodevelopment at 4 months. Immunoglobulin G was measured at birth, 2-3 days and 4 months. Parents recorded any symptoms indicating infection during the first 4 months of life. Results The total scores from the ASQ did not differ between groups. However, the delayed cord clamping (DCC) group had a higher mean (SD) score in the problem-solving domain [55.3 (7.2) vs. 53.5 (8.2), p = 0.03] at 4 months and a lower mean (SD) score in the personal-social domain [49.5 (9.3) vs. 51.8 (8.1), p = 0.01]. The IgG level was higher in the DCC group at 2-3 days (11.7 vs. 11.0 g/L, p = 0.004), but did not differ between the groups at 4 months. Symptoms of infection were comparable between the groups. Conclusion Delayed cord clamping did not affect overall neurodevelopment or symptoms of infection up to 4 months of age, but may have an impact on specific neurodevelopmental domains.
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- author
- Andersson, Ola LU ; Domellöf, Magnus ; Andersson, Dan and Hellström-Westas, Lena LU
- publishing date
- 2013-05-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Infant, Infection, Neurodevelopment, Umbilical cord clamping
- in
- Acta Paediatrica, International Journal of Paediatrics
- volume
- 102
- issue
- 5
- pages
- 7 pages
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:84876108728
- pmid:23336628
- ISSN
- 0803-5253
- DOI
- 10.1111/apa.12168
- language
- English
- LU publication?
- no
- id
- eb879c35-d9eb-4915-9a4f-b333274b677d
- date added to LUP
- 2019-06-19 06:43:25
- date last changed
- 2024-07-24 22:05:20
@article{eb879c35-d9eb-4915-9a4f-b333274b677d, abstract = {{<p>Aim To investigate the effect that delayed and early umbilical cord clamping have on neurodevelopment, immunoglobulin G (IgG) and symptoms of infection during the first 4 months of life. Methods Full-term infants (n = 382) were randomised to delayed (≥180 sec) or early cord clamping (≤10 sec). The Ages and Stages Questionnaire (ASQ) was used to assess neurodevelopment at 4 months. Immunoglobulin G was measured at birth, 2-3 days and 4 months. Parents recorded any symptoms indicating infection during the first 4 months of life. Results The total scores from the ASQ did not differ between groups. However, the delayed cord clamping (DCC) group had a higher mean (SD) score in the problem-solving domain [55.3 (7.2) vs. 53.5 (8.2), p = 0.03] at 4 months and a lower mean (SD) score in the personal-social domain [49.5 (9.3) vs. 51.8 (8.1), p = 0.01]. The IgG level was higher in the DCC group at 2-3 days (11.7 vs. 11.0 g/L, p = 0.004), but did not differ between the groups at 4 months. Symptoms of infection were comparable between the groups. Conclusion Delayed cord clamping did not affect overall neurodevelopment or symptoms of infection up to 4 months of age, but may have an impact on specific neurodevelopmental domains.</p>}}, author = {{Andersson, Ola and Domellöf, Magnus and Andersson, Dan and Hellström-Westas, Lena}}, issn = {{0803-5253}}, keywords = {{Infant; Infection; Neurodevelopment; Umbilical cord clamping}}, language = {{eng}}, month = {{05}}, number = {{5}}, pages = {{525--531}}, publisher = {{Wiley-Blackwell}}, series = {{Acta Paediatrica, International Journal of Paediatrics}}, title = {{Effects of delayed cord clamping on neurodevelopment and infection at four months of age : A randomised trial}}, url = {{http://dx.doi.org/10.1111/apa.12168}}, doi = {{10.1111/apa.12168}}, volume = {{102}}, year = {{2013}}, }