Lp-PLA 2 activity and mass and CRP are associated with incident symptomatic peripheral arterial disease
(2019) In Scientific Reports 9(1).- Abstract
Long follow up is needed in prospective cohort study evaluation of plasma biomarkers for incident peripheral arterial disease (PAD) Middle-aged PAD-free individuals from the cardiovascular cohort of the Malmö Diet and Cancer study (n = 5550; 1991–94) were followed prospectively for a median time of 23.4 years. The plasma biomarkers lipoprotein-associated phospholipase A2 (Lp-PLA
2
) activity and mass, proneurotensin, and CRP, were studied in relation to incidence of PAD until December 31
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Long follow up is needed in prospective cohort study evaluation of plasma biomarkers for incident peripheral arterial disease (PAD) Middle-aged PAD-free individuals from the cardiovascular cohort of the Malmö Diet and Cancer study (n = 5550; 1991–94) were followed prospectively for a median time of 23.4 years. The plasma biomarkers lipoprotein-associated phospholipase A2 (Lp-PLA
2
) activity and mass, proneurotensin, and CRP, were studied in relation to incidence of PAD until December 31
st
, 2016. The diagnosis of PAD could be validated and confirmed in 98%. Cox regression was used to calculate hazard ratios (HR) per 1 standard deviation increment of each respective log transformed plasma biomarker. Cumulative incidence of PAD was 4.4% (men 5.9%, women 3.3%). Adjusting for age, gender, smoking, body mass index, hypertension, diabetes mellitus, Lp-PLA
2
activity (HR 1.33; 95% CI 1.17–1.52), Lp-PLA
2
mass (HR 1.20; 95% CI 1.05–1.37) and CRP (HR 1.55; 95% CI 1.36–1.76) remained independently associated with incident PAD. The plasma biomarkers Lp-PLA
2
activity and mass, and CRP were markers of PAD risk, implying that they might be useful biomarkers for subclinical atherosclerosis and atherosclerotic disease.
- author
- Fatemi, Shahab LU ; Gottsäter, Anders LU ; Zarrouk, Moncef LU ; Engström, Gunnar LU ; Melander, Olle LU ; Persson, Margaretha LU and Acosta, Stefan LU
- organization
-
- Vascular Diseases - Clinical Research (research group)
- Cardiovascular Research - Epidemiology (research group)
- EpiHealth: Epidemiology for Health
- Cardiovascular Research - Hypertension (research group)
- EXODIAB: Excellence of Diabetes Research in Sweden
- Internal Medicine - Epidemiology (research group)
- publishing date
- 2019-04-04
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Scientific Reports
- volume
- 9
- issue
- 1
- article number
- 5609
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:30948779
- scopus:85063989570
- ISSN
- 2045-2322
- DOI
- 10.1038/s41598-019-42154-5
- language
- English
- LU publication?
- yes
- id
- ebc89987-226d-4fcc-a2ad-26c57ee32d34
- date added to LUP
- 2019-04-24 08:35:40
- date last changed
- 2024-10-16 23:01:46
@article{ebc89987-226d-4fcc-a2ad-26c57ee32d34, abstract = {{<p><br> Long follow up is needed in prospective cohort study evaluation of plasma biomarkers for incident peripheral arterial disease (PAD) Middle-aged PAD-free individuals from the cardiovascular cohort of the Malmö Diet and Cancer study (n = 5550; 1991–94) were followed prospectively for a median time of 23.4 years. The plasma biomarkers lipoprotein-associated phospholipase A2 (Lp-PLA <br> <sub>2</sub><br> ) activity and mass, proneurotensin, and CRP, were studied in relation to incidence of PAD until December 31 <br> <sup>st</sup><br> , 2016. The diagnosis of PAD could be validated and confirmed in 98%. Cox regression was used to calculate hazard ratios (HR) per 1 standard deviation increment of each respective log transformed plasma biomarker. Cumulative incidence of PAD was 4.4% (men 5.9%, women 3.3%). Adjusting for age, gender, smoking, body mass index, hypertension, diabetes mellitus, Lp-PLA <br> <sub>2</sub><br> activity (HR 1.33; 95% CI 1.17–1.52), Lp-PLA <br> <sub>2</sub><br> mass (HR 1.20; 95% CI 1.05–1.37) and CRP (HR 1.55; 95% CI 1.36–1.76) remained independently associated with incident PAD. The plasma biomarkers Lp-PLA <br> <sub>2</sub><br> activity and mass, and CRP were markers of PAD risk, implying that they might be useful biomarkers for subclinical atherosclerosis and atherosclerotic disease. <br> </p>}}, author = {{Fatemi, Shahab and Gottsäter, Anders and Zarrouk, Moncef and Engström, Gunnar and Melander, Olle and Persson, Margaretha and Acosta, Stefan}}, issn = {{2045-2322}}, language = {{eng}}, month = {{04}}, number = {{1}}, publisher = {{Nature Publishing Group}}, series = {{Scientific Reports}}, title = {{Lp-PLA <sub>2</sub> activity and mass and CRP are associated with incident symptomatic peripheral arterial disease}}, url = {{http://dx.doi.org/10.1038/s41598-019-42154-5}}, doi = {{10.1038/s41598-019-42154-5}}, volume = {{9}}, year = {{2019}}, }