Hormone status in occupational toluene exposure
(1992) In American Journal of Industrial Medicine 22(1). p.99-107- Abstract
Twenty toluene-exposed rotogravure printers, without signs of solvent-induced toxic encephalopathy, had lower median plasma levels of follicle stimulating hormone (FSH) (3.2 vs. 4.9 IU/L; p = .02) and luteinizing hormone (LH) (6.4 vs. 7.2 IU/L; p = .05) and also lower serum levels of free testosterone (7.8 vs. 86.8 pmol/L; p = .05), respectively, than 44 unexposed referents. The individual time-weighted toluene levels in air were 36 (median; range 8-111) ppm. The printers' median toluene levels in blood were 1.7 (1.0-6.6) mumol/l, and in subcutaneous adipose tissue 5.7 (2.5-21) mg/kg fat. There was a negative association between blood toluene and plasma levels of prolactin. In eight printers, the levels of FSH and LH increased during a... (More)
Twenty toluene-exposed rotogravure printers, without signs of solvent-induced toxic encephalopathy, had lower median plasma levels of follicle stimulating hormone (FSH) (3.2 vs. 4.9 IU/L; p = .02) and luteinizing hormone (LH) (6.4 vs. 7.2 IU/L; p = .05) and also lower serum levels of free testosterone (7.8 vs. 86.8 pmol/L; p = .05), respectively, than 44 unexposed referents. The individual time-weighted toluene levels in air were 36 (median; range 8-111) ppm. The printers' median toluene levels in blood were 1.7 (1.0-6.6) mumol/l, and in subcutaneous adipose tissue 5.7 (2.5-21) mg/kg fat. There was a negative association between blood toluene and plasma levels of prolactin. In eight printers, the levels of FSH and LH increased during a 4 week vacation, while the levels of thyroid stimulating hormone, free triiodothyronine, and free thyroxine decreased during the same period. The results indicate a slight, reversible effect of toluene on the cortical level or on the hypothalamic-pituitary axis at exposures well below the permissible levels, possibly mediated through an effect on catecholamine neurotransmission.
(Less)
- author
- Svensson, B G ; Nise, G ; Erfurth, E M LU ; Nilsson, A and Skerfving, S LU
- publishing date
- 1992
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adipose Tissue/chemistry, Adult, Air Pollutants, Occupational/adverse effects, Follicle Stimulating Hormone/blood, Humans, Luteinizing Hormone/blood, Male, Middle Aged, Occupational Exposure/adverse effects, Printing, Prolactin/blood, Testosterone/blood, Thyrotropin/blood, Toluene/adverse effects
- in
- American Journal of Industrial Medicine
- volume
- 22
- issue
- 1
- pages
- 99 - 107
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- scopus:0026748680
- pmid:1415282
- ISSN
- 0271-3586
- DOI
- 10.1002/ajim.4700220109
- language
- English
- LU publication?
- no
- id
- ecc53257-aa5d-4ad6-b98e-e2d9631ff743
- date added to LUP
- 2023-11-27 10:38:32
- date last changed
- 2024-07-19 15:49:37
@article{ecc53257-aa5d-4ad6-b98e-e2d9631ff743, abstract = {{<p>Twenty toluene-exposed rotogravure printers, without signs of solvent-induced toxic encephalopathy, had lower median plasma levels of follicle stimulating hormone (FSH) (3.2 vs. 4.9 IU/L; p = .02) and luteinizing hormone (LH) (6.4 vs. 7.2 IU/L; p = .05) and also lower serum levels of free testosterone (7.8 vs. 86.8 pmol/L; p = .05), respectively, than 44 unexposed referents. The individual time-weighted toluene levels in air were 36 (median; range 8-111) ppm. The printers' median toluene levels in blood were 1.7 (1.0-6.6) mumol/l, and in subcutaneous adipose tissue 5.7 (2.5-21) mg/kg fat. There was a negative association between blood toluene and plasma levels of prolactin. In eight printers, the levels of FSH and LH increased during a 4 week vacation, while the levels of thyroid stimulating hormone, free triiodothyronine, and free thyroxine decreased during the same period. The results indicate a slight, reversible effect of toluene on the cortical level or on the hypothalamic-pituitary axis at exposures well below the permissible levels, possibly mediated through an effect on catecholamine neurotransmission.</p>}}, author = {{Svensson, B G and Nise, G and Erfurth, E M and Nilsson, A and Skerfving, S}}, issn = {{0271-3586}}, keywords = {{Adipose Tissue/chemistry; Adult; Air Pollutants, Occupational/adverse effects; Follicle Stimulating Hormone/blood; Humans; Luteinizing Hormone/blood; Male; Middle Aged; Occupational Exposure/adverse effects; Printing; Prolactin/blood; Testosterone/blood; Thyrotropin/blood; Toluene/adverse effects}}, language = {{eng}}, number = {{1}}, pages = {{99--107}}, publisher = {{John Wiley & Sons Inc.}}, series = {{American Journal of Industrial Medicine}}, title = {{Hormone status in occupational toluene exposure}}, url = {{http://dx.doi.org/10.1002/ajim.4700220109}}, doi = {{10.1002/ajim.4700220109}}, volume = {{22}}, year = {{1992}}, }