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Demonstration of antibodies binding to autologous and allogeneic leukemic cells in childhood ALL - Evidence for a common ALL antigen(s)

Fäldt, R. LU ; Ankerst, J. LU orcid and Garwicz, S. LU (1986) In Blut 52(6). p.337-343
Abstract

The humoral immune response to autologous leukemic cells was investigated in childhood ALL using a 125I protein A binding assay. In 5/7 patients antibodies were demonstrated at diagnosis and in 3/7 cases also after chemotherapy. Sera from 2/3 patients, which bound significantly to autologous leukemic cells, did not bind significantly to autologous remission cells. In allogeneic experiments sera bound significantly to ALL leukemic cells (6/7 positive combinations), but not to AML leukemic cells (8/8 negative combinations). We propose that ALL sera contain antibodies binding to autologous leukemic cells and that they are directed against a common ALL antigen(s).

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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
I protein A binding assay, Acute lymphoblastic leukemia, Antibodies
in
Blut
volume
52
issue
6
pages
337 - 343
publisher
Springer
external identifiers
  • scopus:0022599273
  • pmid:2941087
ISSN
0006-5242
DOI
10.1007/BF00320780
language
English
LU publication?
yes
id
f04422f3-ad49-4b64-b068-169be4fb25c4
date added to LUP
2021-01-07 16:10:04
date last changed
2025-10-14 12:35:08
@article{f04422f3-ad49-4b64-b068-169be4fb25c4,
  abstract     = {{<p>The humoral immune response to autologous leukemic cells was investigated in childhood ALL using a <sup>125</sup>I protein A binding assay. In 5/7 patients antibodies were demonstrated at diagnosis and in 3/7 cases also after chemotherapy. Sera from 2/3 patients, which bound significantly to autologous leukemic cells, did not bind significantly to autologous remission cells. In allogeneic experiments sera bound significantly to ALL leukemic cells (6/7 positive combinations), but not to AML leukemic cells (8/8 negative combinations). We propose that ALL sera contain antibodies binding to autologous leukemic cells and that they are directed against a common ALL antigen(s).</p>}},
  author       = {{Fäldt, R. and Ankerst, J. and Garwicz, S.}},
  issn         = {{0006-5242}},
  keywords     = {{I protein A binding assay; Acute lymphoblastic leukemia; Antibodies}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{337--343}},
  publisher    = {{Springer}},
  series       = {{Blut}},
  title        = {{Demonstration of antibodies binding to autologous and allogeneic leukemic cells in childhood ALL - Evidence for a common ALL antigen(s)}},
  url          = {{http://dx.doi.org/10.1007/BF00320780}},
  doi          = {{10.1007/BF00320780}},
  volume       = {{52}},
  year         = {{1986}},
}