Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Right ventricular longitudinal function is linked to left ventricular filling pressure in patients with repaired tetralogy of fallot

Johansson, Martin LU ; Binka, Edem ; Barnes, Benjamin ; Gaur, Lasya ; Hedström, Erik LU orcid ; Kutty, Shelby and Carlsson, Marcus LU (2023) In International Journal of Cardiovascular Imaging 39(2). p.401-409
Abstract (Swedish)
Experimental data on pulmonary regurgitation has linked right ventricular longitudinal function to left ventricular filling pressure in animals with induced and treated pulmonary regurgitation but this relationship has not been investigated in patients with repaired Tetralogy of Fallot (rToF). The aim of this study was to determine if right ventricular longitudinal function assessed using cardiovascular magnetic resonance (CMR) is associated with left ventricular filling pressure in patients with rToF. A second objective of this study was to determine if direction of septal movement is related to right ventricular pressure load in rToF. Eighteen patients with rToF undergoing CMR and heart catheterization prior to pulmonary valve... (More)
Experimental data on pulmonary regurgitation has linked right ventricular longitudinal function to left ventricular filling pressure in animals with induced and treated pulmonary regurgitation but this relationship has not been investigated in patients with repaired Tetralogy of Fallot (rToF). The aim of this study was to determine if right ventricular longitudinal function assessed using cardiovascular magnetic resonance (CMR) is associated with left ventricular filling pressure in patients with rToF. A second objective of this study was to determine if direction of septal movement is related to right ventricular pressure load in rToF. Eighteen patients with rToF undergoing CMR and heart catheterization prior to pulmonary valve replacement were retrospectively included and catheter-based pressure measurements were compared with CMR-derived RV regional function. Left ventricular filling pressure was measured as precapillary wedge pressure (PCWP). Longitudinal contribution to RV stroke volume correlated with PCWP (r = 0.48; p = 0.046) but not with RV EF or pulmonary regurgitation. Neither RV longitudinal strain nor TAPSE showed correlation with PCWP. Longitudinal contribution to stroke volume was lower for the RV compared to the LV (49 vs 54%; p = 0.039). Direction of septal movement did not show a correlation with RV end-systolic pressure. Right ventricular longitudinal pumping is associated with left ventricular filling pressure in rToF-patients and this inter-ventricular coupling may explain LV underfilling in patients with pulmonary regurgitation and rToF and may be of value to determine right ventricular dysfunction. RV systolic pressure, however, cannot be assessed from the direction of septal movement, in these patients. (Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Cardiovascular Imaging
volume
39
issue
2
pages
401 - 409
publisher
Springer
external identifiers
  • pmid:36115891
  • scopus:85146237126
ISSN
1875-8312
DOI
10.1007/s10554-022-02728-3
language
Swedish
LU publication?
yes
id
f187ac31-ac5a-439c-9be1-7ee772e14f05
date added to LUP
2022-10-18 16:10:39
date last changed
2023-09-15 14:31:53
@article{f187ac31-ac5a-439c-9be1-7ee772e14f05,
  abstract     = {{Experimental data on pulmonary regurgitation has linked right ventricular longitudinal function to left ventricular filling pressure in animals with induced and treated pulmonary regurgitation but this relationship has not been investigated in patients with repaired Tetralogy of Fallot (rToF). The aim of this study was to determine if right ventricular longitudinal function assessed using cardiovascular magnetic resonance (CMR) is associated with left ventricular filling pressure in patients with rToF. A second objective of this study was to determine if direction of septal movement is related to right ventricular pressure load in rToF. Eighteen patients with rToF undergoing CMR and heart catheterization prior to pulmonary valve replacement were retrospectively included and catheter-based pressure measurements were compared with CMR-derived RV regional function. Left ventricular filling pressure was measured as precapillary wedge pressure (PCWP). Longitudinal contribution to RV stroke volume correlated with PCWP (r = 0.48; p = 0.046) but not with RV EF or pulmonary regurgitation. Neither RV longitudinal strain nor TAPSE showed correlation with PCWP. Longitudinal contribution to stroke volume was lower for the RV compared to the LV (49 vs 54%; p = 0.039). Direction of septal movement did not show a correlation with RV end-systolic pressure. Right ventricular longitudinal pumping is associated with left ventricular filling pressure in rToF-patients and this inter-ventricular coupling may explain LV underfilling in patients with pulmonary regurgitation and rToF and may be of value to determine right ventricular dysfunction. RV systolic pressure, however, cannot be assessed from the direction of septal movement, in these patients.}},
  author       = {{Johansson, Martin and Binka, Edem and Barnes, Benjamin and Gaur, Lasya and Hedström, Erik and Kutty, Shelby and Carlsson, Marcus}},
  issn         = {{1875-8312}},
  language     = {{swe}},
  number       = {{2}},
  pages        = {{401--409}},
  publisher    = {{Springer}},
  series       = {{International Journal of Cardiovascular Imaging}},
  title        = {{Right ventricular longitudinal function is linked to left ventricular filling pressure in patients with repaired tetralogy of fallot}},
  url          = {{http://dx.doi.org/10.1007/s10554-022-02728-3}},
  doi          = {{10.1007/s10554-022-02728-3}},
  volume       = {{39}},
  year         = {{2023}},
}