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Long-term exposure to transportation noise and ischemic heart disease : A pooled analysis of nine scandinavian cohorts

Pyko, Andrei ; Roswall, Nina ; Ögren, Mikael ; Oudin, Anna LU ; Rosengren, Annika ; Eriksson, Charlotta ; Segersson, David ; Rizzuto, Debora ; Andersson, Eva M. and Aasvang, Gunn Marit , et al. (2023) In Environmental Health Perspectives 131(1).
Abstract

BACKGROUND: Transportation noise may induce cardiovascular disease, but the public health implications are unclear. OBJECTIVES: The study aimed to assess exposure-response relationships for different transportation noise sources and ischemic heart disease (IHD), including subtypes. METHODS: Pooled analyses were performed of nine cohorts from Denmark and Sweden, together including 132,801 subjects. Time-weighted long-term exposure to road, railway, and aircraft noise, as well as air pollution, was estimated based on residential histories. Hazard ratios (HRs) were cal-culated using Cox proportional hazards models following adjustment for lifestyle and socioeconomic risk factors. RESULTS: A total of 22,459 incident cases of IHD were... (More)

BACKGROUND: Transportation noise may induce cardiovascular disease, but the public health implications are unclear. OBJECTIVES: The study aimed to assess exposure-response relationships for different transportation noise sources and ischemic heart disease (IHD), including subtypes. METHODS: Pooled analyses were performed of nine cohorts from Denmark and Sweden, together including 132,801 subjects. Time-weighted long-term exposure to road, railway, and aircraft noise, as well as air pollution, was estimated based on residential histories. Hazard ratios (HRs) were cal-culated using Cox proportional hazards models following adjustment for lifestyle and socioeconomic risk factors. RESULTS: A total of 22,459 incident cases of IHD were identified during follow-up from national patient and mortality registers, including 7,682 cases of myocardial infarction. The adjusted HR for IHD was 1.03 [95% confidence interval (CI) 1.00, 1.05] per 10 dB Lden for both road and railway noise exposure during 5 y prior to the event. Higher risks were indicated for IHD excluding angina pectoris cases, with HRs of 1.06 (95% CI: 1.03, 1.08) and 1.05 (95% CI: 1.01, 1.08) per 10 dB Lden for road and railway noise, respectively. Corresponding HRs for myo-cardial infarction were 1.02 (95% CI: 0.99, 1.05) and 1.04 (95% CI: 0.99, 1.08). Increased risks were observed for aircraft noise but without clear exposure-response relations. A threshold at around 55 dB Lden was suggested in the exposure-response relation for road traffic noise and IHD. DISCUSSION: Exposure to road, railway, and aircraft noise in the prior 5 y was associated with an increased risk of IHD, particularly after exclusion of angina pectoris cases, which are less well identified in the registries.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Environmental Health Perspectives
volume
131
issue
1
article number
017003
publisher
National Institute of Environmental Health Sciences
external identifiers
  • scopus:85145955612
  • pmid:36607286
ISSN
0091-6765
DOI
10.1289/EHP10745
language
English
LU publication?
yes
id
f87dd2cb-98be-4b2d-8c66-8492f794b5ef
date added to LUP
2023-02-17 09:52:31
date last changed
2024-05-14 19:57:59
@article{f87dd2cb-98be-4b2d-8c66-8492f794b5ef,
  abstract     = {{<p>BACKGROUND: Transportation noise may induce cardiovascular disease, but the public health implications are unclear. OBJECTIVES: The study aimed to assess exposure-response relationships for different transportation noise sources and ischemic heart disease (IHD), including subtypes. METHODS: Pooled analyses were performed of nine cohorts from Denmark and Sweden, together including 132,801 subjects. Time-weighted long-term exposure to road, railway, and aircraft noise, as well as air pollution, was estimated based on residential histories. Hazard ratios (HRs) were cal-culated using Cox proportional hazards models following adjustment for lifestyle and socioeconomic risk factors. RESULTS: A total of 22,459 incident cases of IHD were identified during follow-up from national patient and mortality registers, including 7,682 cases of myocardial infarction. The adjusted HR for IHD was 1.03 [95% confidence interval (CI) 1.00, 1.05] per 10 dB L<sub>den</sub> for both road and railway noise exposure during 5 y prior to the event. Higher risks were indicated for IHD excluding angina pectoris cases, with HRs of 1.06 (95% CI: 1.03, 1.08) and 1.05 (95% CI: 1.01, 1.08) per 10 dB L<sub>den</sub> for road and railway noise, respectively. Corresponding HRs for myo-cardial infarction were 1.02 (95% CI: 0.99, 1.05) and 1.04 (95% CI: 0.99, 1.08). Increased risks were observed for aircraft noise but without clear exposure-response relations. A threshold at around 55 dB L<sub>den</sub> was suggested in the exposure-response relation for road traffic noise and IHD. DISCUSSION: Exposure to road, railway, and aircraft noise in the prior 5 y was associated with an increased risk of IHD, particularly after exclusion of angina pectoris cases, which are less well identified in the registries.</p>}},
  author       = {{Pyko, Andrei and Roswall, Nina and Ögren, Mikael and Oudin, Anna and Rosengren, Annika and Eriksson, Charlotta and Segersson, David and Rizzuto, Debora and Andersson, Eva M. and Aasvang, Gunn Marit and Engström, Gunnar and Gudjonsdottir, Hrafnhildur and Jørgensen, Jeanette T. and Selander, Jenny and Christensen, Jesper H. and Brandt, Jørgen and Leander, Karin and Overvad, Kim and Eneroth, Kristina and Mattisson, Kristoffer and Barregard, Lars and Stockfelt, Leo and Albin, Maria and Simonsen, Mette K. and Tiittanen, Pekka and Molnar, Peter and Ljungman, Petter and Jensen, Steen Solvang and Gustafsson, Susanna and Lanki, Timo and Lim, Youn Hee and Andersen, Zorana J. and Sørensen, Mette and Pershagen, Göran}},
  issn         = {{0091-6765}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{National Institute of Environmental Health Sciences}},
  series       = {{Environmental Health Perspectives}},
  title        = {{Long-term exposure to transportation noise and ischemic heart disease : A pooled analysis of nine scandinavian cohorts}},
  url          = {{http://dx.doi.org/10.1289/EHP10745}},
  doi          = {{10.1289/EHP10745}},
  volume       = {{131}},
  year         = {{2023}},
}