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The proportion cured of patients with resected stage ii–iii cutaneous melanoma in sweden

Eriksson, Hanna ; Utjés, Deborah ; Olofsson, Roger Bagge ; Gillgren, Peter ; Isaksson, Karolin LU ; Lapins, Jan ; Schultz, Inkeri Leonardsson ; Lyth, Johan and Andersson, Therese M.L. (2021) In Cancers 13(10).
Abstract

Background: Cure proportion represents the proportion of patients who experience the same mortality rate as the general population and can be estimated together with the survival of the proportion experiencing excess mortality (the uncured). The aim was to estimate the cure proportions and survival among uncured stage II–III cutaneous melanoma (CM) patients. Methods: 1‐ and 5‐year relative survival ratios, cure proportions and the median survival times of uncured stage II–III CM patients in Sweden (n = 6466) were calculated based on data from the nationwide popu-lation‐based Swedish Melanoma Register 2005–2013 with a follow‐up through 2018. Results: Stages IIB and IIC showed significant differences in standardized cure proportions vs.... (More)

Background: Cure proportion represents the proportion of patients who experience the same mortality rate as the general population and can be estimated together with the survival of the proportion experiencing excess mortality (the uncured). The aim was to estimate the cure proportions and survival among uncured stage II–III cutaneous melanoma (CM) patients. Methods: 1‐ and 5‐year relative survival ratios, cure proportions and the median survival times of uncured stage II–III CM patients in Sweden (n = 6466) were calculated based on data from the nationwide popu-lation‐based Swedish Melanoma Register 2005–2013 with a follow‐up through 2018. Results: Stages IIB and IIC showed significant differences in standardized cure proportions vs. stage IIA CM (0.80 (95% CI 0.77–0.83) stage IIA; 0.62 (95% CI 0.59–0.66) stage IIB; 0.42 (95% CI 0.37–0.46) for stage IIC). Significant differences in standardized cure proportions were found for stages IIIB and IIIC‐D CM vs. stage IIIA (0.76 (95% CI 0.68–0.84) stage IIIA; 0.52 (95% CI 0.45–0.59) stage IIIB; 0.35 (95% CI 0.30– 0.39) for stage IIIC–D). Conclusions: The results are emphasizing the poor prognosis with low proportions cured by surgery only for sub‐groups of stage II–III CM, specifically within stages IIB–C CM.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cure proportions, Median survival times, Stage II–III melanoma, Survival ratios, Uncured patients
in
Cancers
volume
13
issue
10
article number
2456
publisher
MDPI AG
external identifiers
  • scopus:85105872154
  • pmid:34070092
ISSN
2072-6694
DOI
10.3390/cancers13102456
language
English
LU publication?
yes
id
fc20edcc-1f46-46a6-bde3-ef9f151af95f
date added to LUP
2021-06-03 14:43:41
date last changed
2024-07-27 16:26:59
@article{fc20edcc-1f46-46a6-bde3-ef9f151af95f,
  abstract     = {{<p>Background: Cure proportion represents the proportion of patients who experience the same mortality rate as the general population and can be estimated together with the survival of the proportion experiencing excess mortality (the uncured). The aim was to estimate the cure proportions and survival among uncured stage II–III cutaneous melanoma (CM) patients. Methods: 1‐ and 5‐year relative survival ratios, cure proportions and the median survival times of uncured stage II–III CM patients in Sweden (n = 6466) were calculated based on data from the nationwide popu-lation‐based Swedish Melanoma Register 2005–2013 with a follow‐up through 2018. Results: Stages IIB and IIC showed significant differences in standardized cure proportions vs. stage IIA CM (0.80 (95% CI 0.77–0.83) stage IIA; 0.62 (95% CI 0.59–0.66) stage IIB; 0.42 (95% CI 0.37–0.46) for stage IIC). Significant differences in standardized cure proportions were found for stages IIIB and IIIC‐D CM vs. stage IIIA (0.76 (95% CI 0.68–0.84) stage IIIA; 0.52 (95% CI 0.45–0.59) stage IIIB; 0.35 (95% CI 0.30– 0.39) for stage IIIC–D). Conclusions: The results are emphasizing the poor prognosis with low proportions cured by surgery only for sub‐groups of stage II–III CM, specifically within stages IIB–C CM.</p>}},
  author       = {{Eriksson, Hanna and Utjés, Deborah and Olofsson, Roger Bagge and Gillgren, Peter and Isaksson, Karolin and Lapins, Jan and Schultz, Inkeri Leonardsson and Lyth, Johan and Andersson, Therese M.L.}},
  issn         = {{2072-6694}},
  keywords     = {{Cure proportions; Median survival times; Stage II–III melanoma; Survival ratios; Uncured patients}},
  language     = {{eng}},
  month        = {{05}},
  number       = {{10}},
  publisher    = {{MDPI AG}},
  series       = {{Cancers}},
  title        = {{The proportion cured of patients with resected stage ii–iii cutaneous melanoma in sweden}},
  url          = {{http://dx.doi.org/10.3390/cancers13102456}},
  doi          = {{10.3390/cancers13102456}},
  volume       = {{13}},
  year         = {{2021}},
}