RIFM fragrance ingredient safety assessment, isobutyl alcohol, CAS Registry Number 78-83-1
(2019) In Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 134.- Abstract
The existing information supports the use of this material as described in this safety assessment. Isobutyl alcohol was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that isobutyl alcohol is not genotoxic. Data on isobutyl alcohol provide a calculated MOE >100 for the repeated dose toxicity and reproductive toxicity endpoints. Data from read-across material isoamyl alcohol (CAS # 123-51-3) show that there are no safety concerns for isobutyl alcohol for skin sensitization under the current declared levels of use. The phototoxicity/photoallergenicity endpoints were evaluated based on UV... (More)
The existing information supports the use of this material as described in this safety assessment. Isobutyl alcohol was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that isobutyl alcohol is not genotoxic. Data on isobutyl alcohol provide a calculated MOE >100 for the repeated dose toxicity and reproductive toxicity endpoints. Data from read-across material isoamyl alcohol (CAS # 123-51-3) show that there are no safety concerns for isobutyl alcohol for skin sensitization under the current declared levels of use. The phototoxicity/photoallergenicity endpoints were evaluated based on UV spectra; isobutyl alcohol is not expected to be phototoxic/photoallergenic. The local respiratory toxicity endpoint was evaluated using the TTC for a Cramer Class I material and the exposure to isobutyl alcohol is below the TTC (1.4 mg/day). The environmental endpoints were evaluated; isobutyl alcohol was found not to be PBT as per the IFRA Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., PEC/PNEC), are <1.
(Less)
- author
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Developmental, and Reproductive, Environmental Safety, Genotoxicity, Local, Phototoxicity/Photoallergenicity, Repeated Dose, Respiratory Toxicity, Skin Sensitization, Toxicity
- in
- Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
- volume
- 134
- article number
- 110999
- publisher
- Elsevier
- external identifiers
-
- pmid:31783104
- scopus:85077174368
- ISSN
- 1873-6351
- DOI
- 10.1016/j.fct.2019.110999
- language
- English
- LU publication?
- no
- id
- fdcc7a51-9a62-47ec-9a3c-24258d151d12
- date added to LUP
- 2020-01-10 14:38:51
- date last changed
- 2022-04-18 20:10:26
@article{fdcc7a51-9a62-47ec-9a3c-24258d151d12, abstract = {{<p>The existing information supports the use of this material as described in this safety assessment. Isobutyl alcohol was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, and environmental safety. Data show that isobutyl alcohol is not genotoxic. Data on isobutyl alcohol provide a calculated MOE >100 for the repeated dose toxicity and reproductive toxicity endpoints. Data from read-across material isoamyl alcohol (CAS # 123-51-3) show that there are no safety concerns for isobutyl alcohol for skin sensitization under the current declared levels of use. The phototoxicity/photoallergenicity endpoints were evaluated based on UV spectra; isobutyl alcohol is not expected to be phototoxic/photoallergenic. The local respiratory toxicity endpoint was evaluated using the TTC for a Cramer Class I material and the exposure to isobutyl alcohol is below the TTC (1.4 mg/day). The environmental endpoints were evaluated; isobutyl alcohol was found not to be PBT as per the IFRA Environmental Standards, and its risk quotients, based on its current volume of use in Europe and North America (i.e., PEC/PNEC), are <1.</p>}}, author = {{Api, A. M. and Belmonte, F. and Belsito, D. and Biserta, S. and Botelho, D. and Bruze, M. and Burton, G. A. and Buschmann, J. and Cancellieri, M. A. and Dagli, M. L. and Date, M. and Dekant, W. and Deodhar, C. and Fryer, A. D. and Gadhia, S. and Jones, L. and Joshi, K. and Lapczynski, A. and Lavelle, M. and Liebler, D. C. and Na, M. and O'Brien, D. and Patel, A. and Penning, T. M. and Ritacco, G. and Rodriguez-Ropero, F. and Romine, J. and Sadekar, N. and Salvito, D. and Schultz, T. W. and Sipes, I. G. and Sullivan, G. and Thakkar, Y. and Tokura, Y. and Tsang, S.}}, issn = {{1873-6351}}, keywords = {{Developmental, and Reproductive; Environmental Safety; Genotoxicity; Local; Phototoxicity/Photoallergenicity; Repeated Dose; Respiratory Toxicity; Skin Sensitization; Toxicity}}, language = {{eng}}, publisher = {{Elsevier}}, series = {{Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association}}, title = {{RIFM fragrance ingredient safety assessment, isobutyl alcohol, CAS Registry Number 78-83-1}}, url = {{http://dx.doi.org/10.1016/j.fct.2019.110999}}, doi = {{10.1016/j.fct.2019.110999}}, volume = {{134}}, year = {{2019}}, }