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Image-Based Dosimetry Procedures

Ljungberg, Michael LU orcid (2025) p.118-130
Abstract

This chapter describes methods and procedures that can be used to calculate the absorbed dose distribution based on quantitative SPECT/PET images. In this context, quantitative images mean images corrected for various physical effects (among them are photon attenuation, scatter contribution, dead time) in such a way that the values of each voxel can then be translated into units of activity by a calibration factor. These quantitative images can serve as input to an estimation of the radiation transport from which dosimetric data are obtained. The main interaction types for charged particles are briefly described together with three methods to obtain the energy distribution around radionuclides. These three methods are (1) assumption of... (More)

This chapter describes methods and procedures that can be used to calculate the absorbed dose distribution based on quantitative SPECT/PET images. In this context, quantitative images mean images corrected for various physical effects (among them are photon attenuation, scatter contribution, dead time) in such a way that the values of each voxel can then be translated into units of activity by a calibration factor. These quantitative images can serve as input to an estimation of the radiation transport from which dosimetric data are obtained. The main interaction types for charged particles are briefly described together with three methods to obtain the energy distribution around radionuclides. These three methods are (1) assumption of local absorbed energy from the emitted radiation within a voxel, (2) analytical convolution with a point-dose kernel to obtain the energy distribution around the voxels, and (3) the use of full Monte-Carlo-based radiation transport to explicit simulate photons and charge-particles in a volume using patient-specific anatomical information. A discussion of the limitations of image-based dosimetry is given, together with information about guidelines and recommendations.

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
host publication
Radiotheranostics -A Primer for Medical Physicists II : Radiochemistry, Radiobiology, Dosimetry, Safety, Economics, and AI - Radiochemistry, Radiobiology, Dosimetry, Safety, Economics, and AI
pages
13 pages
publisher
CRC Press/Balkema
external identifiers
  • scopus:105025607095
ISBN
9781032659701
9781040442746
DOI
10.1201/9781032668413-14
language
English
LU publication?
yes
id
feb4ec10-8227-443b-bf55-2ada01c358d8
date added to LUP
2026-02-23 14:43:16
date last changed
2026-03-23 21:59:18
@inbook{feb4ec10-8227-443b-bf55-2ada01c358d8,
  abstract     = {{<p>This chapter describes methods and procedures that can be used to calculate the absorbed dose distribution based on quantitative SPECT/PET images. In this context, quantitative images mean images corrected for various physical effects (among them are photon attenuation, scatter contribution, dead time) in such a way that the values of each voxel can then be translated into units of activity by a calibration factor. These quantitative images can serve as input to an estimation of the radiation transport from which dosimetric data are obtained. The main interaction types for charged particles are briefly described together with three methods to obtain the energy distribution around radionuclides. These three methods are (1) assumption of local absorbed energy from the emitted radiation within a voxel, (2) analytical convolution with a point-dose kernel to obtain the energy distribution around the voxels, and (3) the use of full Monte-Carlo-based radiation transport to explicit simulate photons and charge-particles in a volume using patient-specific anatomical information. A discussion of the limitations of image-based dosimetry is given, together with information about guidelines and recommendations.</p>}},
  author       = {{Ljungberg, Michael}},
  booktitle    = {{Radiotheranostics -A Primer for Medical Physicists II : Radiochemistry, Radiobiology, Dosimetry, Safety, Economics, and AI}},
  isbn         = {{9781032659701}},
  language     = {{eng}},
  month        = {{01}},
  pages        = {{118--130}},
  publisher    = {{CRC Press/Balkema}},
  title        = {{Image-Based Dosimetry Procedures}},
  url          = {{http://dx.doi.org/10.1201/9781032668413-14}},
  doi          = {{10.1201/9781032668413-14}},
  year         = {{2025}},
}