Hakon Leffler

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2023
Mark Strong Binding of C-Glycosylic1,2-Thiodisaccharides to Galectin-3─Enthalpy-Driven Affinity Enhancement by Water-Mediated Hydrogen Bonds
Lázár, László ; Tsagkarakou, Anastasia S ; Stravodimos, George ; Kontopidis, George ; Leffler, Hakon ^LU ; Nilsson, Ulf J ^LU ; Somsák, László and Leonidas, Demetres D (2023) In Journal of Medicinal Chemistry 66(17). p.12420-12431
- Contribution to journal › Article
Mark Evaluating the affinity and kinetics of small molecule glycomimetics for human and mouse galectin-3 using surface plasmon resonance
Kim, Henry ; Weidner, Nathalie ; Ronin, Céline ; Klein, Emmanuel ; Roper, James A. ; Kahl-Knutson, Barbro ^LU ; Peterson, Kristoffer ^LU ; Leffler, Hakon ^LU ; Nilsson, Ulf J. ^LU and Pedersen, Anders , et al. (2023) In SLAS Discovery 28(5). p.233-239
- Contribution to journal › Article
Mark Novel inhibitory effect of galectin-3 on the respiratory burst induced by Staphylococcus aureus in human neutrophils
Venkatakrishnan, Vignesh ; Elmwall, Jonas ; Lahiri, Trisha ^LU ; Sundqvist, Martina ; Bergqvist, Linda ; Leffler, Hakon ^LU ; Nilsson, Ulf J ^LU ; Welin, Amanda ; Bylund, Johan and Karlsson-Bengtsson, Anna (2023) In Glycobiology 33(6). p.503-511
- Contribution to journal › Article
Mark Safety and pharmacokinetics of GB1211, an oral galectin-3 inhibitor : a single- and multiple-dose first-in-human study in healthy participants
Aslanis, Vassilios ; Slack, Robert J. ; MacKinnon, Alison C. ; McClinton, Catherine ; Tantawi, Susan ; Gravelle, Lise ; Nilsson, Ulf J. ^LU ; Leffler, Hakon ^LU ; Brooks, Ashley and Khindri, Sanjeev K. , et al. (2023) In Cancer Chemotherapy and Pharmacology 91(3). p.267-280
- Contribution to journal › Article
Mark Galectin-1 induces a tumor-associated macrophage phenotype and upregulates indoleamine 2,3-dioxygenase-1
Rudjord-Levann, Asha M. ; Ye, Zilu ; Hafkenscheid, Lise ; Horn, Sabrina ; Wiegertjes, Renske ; Nielsen, Mathias A.I. ; Song, Ming ; Mathiesen, Caroline B.K. ; Stoop, Jesse and Stowell, Sean , et al. (2023) In iScience 26(7).
- Contribution to journal › Article
Mark Discovery of Selective and Orally Available Galectin-1 Inhibitors
Zetterberg, Fredrik R ; Diehl, Carl ^LU ; Håkansson, Maria ^LU ; Kahl-Knutson, Barbro ^LU ; Leffler, Hakon ^LU ; Nilsson, Ulf J ^LU ; Peterson, Kristoffer ^LU ; Roper, James A and Slack, Robert J (2023) In Journal of Medicinal Chemistry 66(24). p.16980-16990
- Contribution to journal › Article
2022
Mark Selective Monovalent Galectin-8 Ligands Based on 3-Lactoylgalactoside
Girardi, Benedetta ; Manna, Martina ; Van Klaveren, Sjors ^LU ; Tomašič, Tihomir ; Jakopin, Žiga ; Leffler, Hakon ^LU ; Nilsson, Ulf J. ^LU ; Ricklin, Daniel ; Mravljak, Janez and Schwardt, Oliver , et al. (2022) In ChemMedChem 17(3).
- Contribution to journal › Article
Mark Engineering the Ligand Specificity of the Human Galectin-1 by Incorporation of Tryptophan Analogues
Tobola, Felix ; Lepšík, Martin ; Zia, Syeda Rehana ; Leffler, Hakon ^LU ; Nilsson, Ulf J. ^LU ; Blixt, Ola ; Imberty, Anne and Wiltschi, Birgit (2022) In ChemBioChem 23(5).
- Contribution to journal › Article
Mark Galectin-9 Signaling Drives Breast Cancer Invasion through Extracellular Matrix
Pally, Dharma ; Banerjee, Mallar ; Hussain, Shahid ; Kumar, Rekha V ; Petersson, Alexandra ^LU ; Rosendal, Ebba ; Gunnarsson, Ludvig ; Peterson, Kristoffer ^LU ; Leffler, Hakon ^LU and Nilsson, Ulf J ^LU , et al. (2022) In ACS Chemical Biology 17(6). p.1376-1386
- Contribution to journal › Article
Mark Site-specific N-glycan profiles of α₅β₁ integrin from rat liver
Mirgorodskaya, Ekaterina ; Dransart, Estelle ; Shafaq-Zadah, Massiullah ; Roderer, Daniel ; Sihlbom, Carina ; Leffler, Hakon ^LU and Johannes, Ludger (2022) In Biology of the Cell 114(6). p.160-176
- Contribution to journal › Article

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