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Growth differentiation factor-15 and incident chronic kidney disease : a population-based cohort study

Bao, Xue LU ; Xu, Biao ; Borné, Yan LU ; Orho-Melander, Marju LU ; Melander, Olle LU orcid ; Nilsson, Jan LU ; Christensson, Anders LU and Engström, Gunnar LU (2021) In BMC Nephrology 22(1).
Abstract

Background: The relationship between growth differentiation factor 15 (GDF-15) and the development of chronic kidney disease (CKD) is still unclear. We sought to examine whether plasma GDF-15 was related to incident CKD and kidney function decline using a large prospective cohort study. Methods: 4318 participants of the Malmö Diet and Cancer Study-Cardiovascular Cohort were examined in 1991-1994. Incidence of CKD was followed prospectively by linkage with national patient registers. Estimated glomerular filtration rate (eGFR) was available for all participants at baseline, and was re-measured in a subgroup of 2744 subjects after 16.6 ± 1.49 years. Incidence of CKD was examined in relation to GDF-15 using Cox regression analysis.... (More)

Background: The relationship between growth differentiation factor 15 (GDF-15) and the development of chronic kidney disease (CKD) is still unclear. We sought to examine whether plasma GDF-15 was related to incident CKD and kidney function decline using a large prospective cohort study. Methods: 4318 participants of the Malmö Diet and Cancer Study-Cardiovascular Cohort were examined in 1991-1994. Incidence of CKD was followed prospectively by linkage with national patient registers. Estimated glomerular filtration rate (eGFR) was available for all participants at baseline, and was re-measured in a subgroup of 2744 subjects after 16.6 ± 1.49 years. Incidence of CKD was examined in relation to GDF-15 using Cox regression analysis. Logistic regression was used to examine the association of GDF-15 with eGFR change and eGFR-based CKD. Models were carefully corrected for potential confounders including baseline eGFR, N-terminal pro-B-type natriuretic peptide, and competing risk from death. Results: 165 patients developed CKD after 19.2 ± 4.04 years of follow-up. The adjusted hazard ratio (95% confidence interval, CI) for CKD in 4th versus 1st quartile of GDF-15 was 2.37 (1.33, 4.24) (p for trend < 0.01). Each per 1 standard deviation increase in GDF-15 was associated with a decline in eGFR of − 0.97 mL/min/1.73 m2 (95% CI, − 1.49 ~ − 0.45; p < 0.001). GDF-15 was also significantly associated eGFR-based CKD in 2713 subjects with baseline eGFR ≥60 mL/min/1.73 m2. Conclusions: GDF-15 predicted incidence of CKD and eGFR decline in the general population, independent of a wide range of potential risk factors and competing risk of death.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Chronic kidney disease, Cohort study, Competing risk, Estimated glomerular filtration rate, Growth differentiation factor 15
in
BMC Nephrology
volume
22
issue
1
article number
351
publisher
BioMed Central (BMC)
external identifiers
  • pmid:34706669
  • scopus:85117891454
ISSN
1471-2369
DOI
10.1186/s12882-021-02558-w
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2021, The Author(s).
id
004159dd-3eb2-4f16-8130-159bf7bd904f
date added to LUP
2021-11-22 12:50:40
date last changed
2025-01-26 20:04:39
@article{004159dd-3eb2-4f16-8130-159bf7bd904f,
  abstract     = {{<p>Background: The relationship between growth differentiation factor 15 (GDF-15) and the development of chronic kidney disease (CKD) is still unclear. We sought to examine whether plasma GDF-15 was related to incident CKD and kidney function decline using a large prospective cohort study. Methods: 4318 participants of the Malmö Diet and Cancer Study-Cardiovascular Cohort were examined in 1991-1994. Incidence of CKD was followed prospectively by linkage with national patient registers. Estimated glomerular filtration rate (eGFR) was available for all participants at baseline, and was re-measured in a subgroup of 2744 subjects after 16.6 ± 1.49 years. Incidence of CKD was examined in relation to GDF-15 using Cox regression analysis. Logistic regression was used to examine the association of GDF-15 with eGFR change and eGFR-based CKD. Models were carefully corrected for potential confounders including baseline eGFR, N-terminal pro-B-type natriuretic peptide, and competing risk from death. Results: 165 patients developed CKD after 19.2 ± 4.04 years of follow-up. The adjusted hazard ratio (95% confidence interval, CI) for CKD in 4th versus 1st quartile of GDF-15 was 2.37 (1.33, 4.24) (p for trend &lt; 0.01). Each per 1 standard deviation increase in GDF-15 was associated with a decline in eGFR of − 0.97 mL/min/1.73 m<sup>2</sup> (95% CI, − 1.49 ~ − 0.45; p &lt; 0.001). GDF-15 was also significantly associated eGFR-based CKD in 2713 subjects with baseline eGFR ≥60 mL/min/1.73 m<sup>2</sup>. Conclusions: GDF-15 predicted incidence of CKD and eGFR decline in the general population, independent of a wide range of potential risk factors and competing risk of death.</p>}},
  author       = {{Bao, Xue and Xu, Biao and Borné, Yan and Orho-Melander, Marju and Melander, Olle and Nilsson, Jan and Christensson, Anders and Engström, Gunnar}},
  issn         = {{1471-2369}},
  keywords     = {{Chronic kidney disease; Cohort study; Competing risk; Estimated glomerular filtration rate; Growth differentiation factor 15}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{BMC Nephrology}},
  title        = {{Growth differentiation factor-15 and incident chronic kidney disease : a population-based cohort study}},
  url          = {{http://dx.doi.org/10.1186/s12882-021-02558-w}},
  doi          = {{10.1186/s12882-021-02558-w}},
  volume       = {{22}},
  year         = {{2021}},
}