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The impact of body size changes on recurrence risk depends on age and estrogen receptor status in primary breast cancer

Tryggvadottir, Helga LU ; Ygland Rödström, Maria ; Markkula, Andrea LU ; Kenéz, Xuyian ; Isaksson, Karolin LU ; Borgquist, Signe LU and Jernström, Helena LU (2019) In Cancer causes & control : CCC 30(11). p.1157-1170
Abstract

PURPOSE: To investigate the prognostic impact of body size changes during the first postoperative year in breast cancer. METHODS: A cohort of 1,317 primary breast cancer patients included in Sweden (2002-2014) underwent body size measurements at the preoperative and 1-year visits (n = 1,178). Landmark survival analyses were used to investigate how postoperative weight gain or loss (> 5%) or change in waist-hip ratio (WHR) categories (≤ 0.85 or > 0.85) impact prognosis. RESULTS: Median age at inclusion was 61 years and body mass index 25.1 kg/m2. After a median follow-up of 5.0 years from inclusion, 165 recurrences and 77 deaths occurred. Weight gain (17.0%) conferred over twofold recurrence risk only in patients < 50 years... (More)

PURPOSE: To investigate the prognostic impact of body size changes during the first postoperative year in breast cancer. METHODS: A cohort of 1,317 primary breast cancer patients included in Sweden (2002-2014) underwent body size measurements at the preoperative and 1-year visits (n = 1,178). Landmark survival analyses were used to investigate how postoperative weight gain or loss (> 5%) or change in waist-hip ratio (WHR) categories (≤ 0.85 or > 0.85) impact prognosis. RESULTS: Median age at inclusion was 61 years and body mass index 25.1 kg/m2. After a median follow-up of 5.0 years from inclusion, 165 recurrences and 77 deaths occurred. Weight gain (17.0%) conferred over twofold recurrence risk only in patients < 50 years (Pinteraction = 0.033). Weight loss (8.6%) was only associated with a poor prognosis in patients ≥ 70 years, but not after restriction analysis. Weight change did not impact prognosis in patients 50 to < 70 years. Changes between WHR categories were associated with differential recurrence risk depending on estrogen receptor (ER) status (Pinteraction = 0.007), with higher recurrence risk in patients with ER+ tumors and lower recurrence risk with ER- tumors. CONCLUSION: Both changes in terms of weight and WHR category yielded independent prognostic information. Further research is imperative before recommending weight loss for all overweight breast cancer patients.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
ABSI, Breast cancer, Prognosis, Waist–hip ratio change, Weight gain, Weight loss
in
Cancer causes & control : CCC
volume
30
issue
11
pages
14 pages
publisher
Springer
external identifiers
  • pmid:31515643
  • scopus:85073085207
ISSN
1573-7225
DOI
10.1007/s10552-019-01227-6
language
English
LU publication?
yes
id
004a6baf-3fe2-4b31-9fec-df7a5b78aca3
date added to LUP
2019-10-21 11:11:26
date last changed
2024-02-15 23:17:31
@article{004a6baf-3fe2-4b31-9fec-df7a5b78aca3,
  abstract     = {{<p>PURPOSE: To investigate the prognostic impact of body size changes during the first postoperative year in breast cancer. METHODS: A cohort of 1,317 primary breast cancer patients included in Sweden (2002-2014) underwent body size measurements at the preoperative and 1-year visits (n = 1,178). Landmark survival analyses were used to investigate how postoperative weight gain or loss (&gt; 5%) or change in waist-hip ratio (WHR) categories (≤ 0.85 or &gt; 0.85) impact prognosis. RESULTS: Median age at inclusion was 61 years and body mass index 25.1 kg/m2. After a median follow-up of 5.0 years from inclusion, 165 recurrences and 77 deaths occurred. Weight gain (17.0%) conferred over twofold recurrence risk only in patients &lt; 50 years (Pinteraction = 0.033). Weight loss (8.6%) was only associated with a poor prognosis in patients ≥ 70 years, but not after restriction analysis. Weight change did not impact prognosis in patients 50 to &lt; 70 years. Changes between WHR categories were associated with differential recurrence risk depending on estrogen receptor (ER) status (Pinteraction = 0.007), with higher recurrence risk in patients with ER+ tumors and lower recurrence risk with ER- tumors. CONCLUSION: Both changes in terms of weight and WHR category yielded independent prognostic information. Further research is imperative before recommending weight loss for all overweight breast cancer patients.</p>}},
  author       = {{Tryggvadottir, Helga and Ygland Rödström, Maria and Markkula, Andrea and Kenéz, Xuyian and Isaksson, Karolin and Borgquist, Signe and Jernström, Helena}},
  issn         = {{1573-7225}},
  keywords     = {{ABSI; Breast cancer; Prognosis; Waist–hip ratio change; Weight gain; Weight loss}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{1157--1170}},
  publisher    = {{Springer}},
  series       = {{Cancer causes & control : CCC}},
  title        = {{The impact of body size changes on recurrence risk depends on age and estrogen receptor status in primary breast cancer}},
  url          = {{http://dx.doi.org/10.1007/s10552-019-01227-6}},
  doi          = {{10.1007/s10552-019-01227-6}},
  volume       = {{30}},
  year         = {{2019}},
}