The impact of body size changes on recurrence risk depends on age and estrogen receptor status in primary breast cancer
(2019) In Cancer causes & control : CCC 30(11). p.1157-1170- Abstract
PURPOSE: To investigate the prognostic impact of body size changes during the first postoperative year in breast cancer. METHODS: A cohort of 1,317 primary breast cancer patients included in Sweden (2002-2014) underwent body size measurements at the preoperative and 1-year visits (n = 1,178). Landmark survival analyses were used to investigate how postoperative weight gain or loss (> 5%) or change in waist-hip ratio (WHR) categories (≤ 0.85 or > 0.85) impact prognosis. RESULTS: Median age at inclusion was 61 years and body mass index 25.1 kg/m2. After a median follow-up of 5.0 years from inclusion, 165 recurrences and 77 deaths occurred. Weight gain (17.0%) conferred over twofold recurrence risk only in patients < 50 years... (More)
PURPOSE: To investigate the prognostic impact of body size changes during the first postoperative year in breast cancer. METHODS: A cohort of 1,317 primary breast cancer patients included in Sweden (2002-2014) underwent body size measurements at the preoperative and 1-year visits (n = 1,178). Landmark survival analyses were used to investigate how postoperative weight gain or loss (> 5%) or change in waist-hip ratio (WHR) categories (≤ 0.85 or > 0.85) impact prognosis. RESULTS: Median age at inclusion was 61 years and body mass index 25.1 kg/m2. After a median follow-up of 5.0 years from inclusion, 165 recurrences and 77 deaths occurred. Weight gain (17.0%) conferred over twofold recurrence risk only in patients < 50 years (Pinteraction = 0.033). Weight loss (8.6%) was only associated with a poor prognosis in patients ≥ 70 years, but not after restriction analysis. Weight change did not impact prognosis in patients 50 to < 70 years. Changes between WHR categories were associated with differential recurrence risk depending on estrogen receptor (ER) status (Pinteraction = 0.007), with higher recurrence risk in patients with ER+ tumors and lower recurrence risk with ER- tumors. CONCLUSION: Both changes in terms of weight and WHR category yielded independent prognostic information. Further research is imperative before recommending weight loss for all overweight breast cancer patients.
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- author
- Tryggvadottir, Helga LU ; Ygland Rödström, Maria ; Markkula, Andrea LU ; Kenéz, Xuyian ; Isaksson, Karolin LU ; Borgquist, Signe LU and Jernström, Helena LU
- organization
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- ABSI, Breast cancer, Prognosis, Waist–hip ratio change, Weight gain, Weight loss
- in
- Cancer causes & control : CCC
- volume
- 30
- issue
- 11
- pages
- 14 pages
- publisher
- Springer
- external identifiers
-
- pmid:31515643
- scopus:85073085207
- ISSN
- 1573-7225
- DOI
- 10.1007/s10552-019-01227-6
- language
- English
- LU publication?
- yes
- id
- 004a6baf-3fe2-4b31-9fec-df7a5b78aca3
- date added to LUP
- 2019-10-21 11:11:26
- date last changed
- 2024-02-15 23:17:31
@article{004a6baf-3fe2-4b31-9fec-df7a5b78aca3, abstract = {{<p>PURPOSE: To investigate the prognostic impact of body size changes during the first postoperative year in breast cancer. METHODS: A cohort of 1,317 primary breast cancer patients included in Sweden (2002-2014) underwent body size measurements at the preoperative and 1-year visits (n = 1,178). Landmark survival analyses were used to investigate how postoperative weight gain or loss (> 5%) or change in waist-hip ratio (WHR) categories (≤ 0.85 or > 0.85) impact prognosis. RESULTS: Median age at inclusion was 61 years and body mass index 25.1 kg/m2. After a median follow-up of 5.0 years from inclusion, 165 recurrences and 77 deaths occurred. Weight gain (17.0%) conferred over twofold recurrence risk only in patients < 50 years (Pinteraction = 0.033). Weight loss (8.6%) was only associated with a poor prognosis in patients ≥ 70 years, but not after restriction analysis. Weight change did not impact prognosis in patients 50 to < 70 years. Changes between WHR categories were associated with differential recurrence risk depending on estrogen receptor (ER) status (Pinteraction = 0.007), with higher recurrence risk in patients with ER+ tumors and lower recurrence risk with ER- tumors. CONCLUSION: Both changes in terms of weight and WHR category yielded independent prognostic information. Further research is imperative before recommending weight loss for all overweight breast cancer patients.</p>}}, author = {{Tryggvadottir, Helga and Ygland Rödström, Maria and Markkula, Andrea and Kenéz, Xuyian and Isaksson, Karolin and Borgquist, Signe and Jernström, Helena}}, issn = {{1573-7225}}, keywords = {{ABSI; Breast cancer; Prognosis; Waist–hip ratio change; Weight gain; Weight loss}}, language = {{eng}}, number = {{11}}, pages = {{1157--1170}}, publisher = {{Springer}}, series = {{Cancer causes & control : CCC}}, title = {{The impact of body size changes on recurrence risk depends on age and estrogen receptor status in primary breast cancer}}, url = {{http://dx.doi.org/10.1007/s10552-019-01227-6}}, doi = {{10.1007/s10552-019-01227-6}}, volume = {{30}}, year = {{2019}}, }