Carcinogen-DNA Adducts
Krais, Annette M. LU
; Singh, Rajinder
and Arlt, Volker M.
(2019)
p.282-295
- Abstract
Carcinogen-DNA adducts result from the covalent interaction of electrophilic chemical carcinogens with nucleophilic sites in DNA. Some highly reactive genotoxic carcinogens are capable of directly binding to DNA but most carcinogens require metabolic activation. DNA adducts, if not repaired, can lead to mutations, and mutations in critical genes are a characteristic feature of tumors. Thus DNA adduct formation is considered a critical step in the initiation of carcinogenesis. DNA adducts formed in human tissues can be detected by a variety of sensitive techniques including 32P-postlabeling, mass spectrometry, accelerator mass spectrometry, and immunoassays. Their detection and characterization in human tissues can provide... (More)
Carcinogen-DNA adducts result from the covalent interaction of electrophilic chemical carcinogens with nucleophilic sites in DNA. Some highly reactive genotoxic carcinogens are capable of directly binding to DNA but most carcinogens require metabolic activation. DNA adducts, if not repaired, can lead to mutations, and mutations in critical genes are a characteristic feature of tumors. Thus DNA adduct formation is considered a critical step in the initiation of carcinogenesis. DNA adducts formed in human tissues can be detected by a variety of sensitive techniques including 32P-postlabeling, mass spectrometry, accelerator mass spectrometry, and immunoassays. Their detection and characterization in human tissues can provide clues on the etiology of human cancer.
(Less)
- author
- Krais, Annette M.
LU
; Singh, Rajinder
and Arlt, Volker M.
- organization
- publishing date
- 2019
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- P-postlabeling, Accelerator, Adductomics, Aflatoxin B, Aristolochic acid, Benzo[a]pyrene, Biomarker of exposure, Chemical carcinogenesis, DNA adduct, Human biomonitoring, Immunoassay, Mass spectrometry, Xenobiotic metabolism
- host publication
- Encyclopedia of Cancer
- editor
- Boffetta, Paolo and Hainaut, Pierre
- edition
- Third Edition
- pages
- 14 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:85079111855
- ISBN
- 9780128124857
- DOI
- 10.1016/B978-0-12-801238-3.65219-4
- language
- English
- LU publication?
- yes
- id
- 00ac8258-16ea-4637-b649-b3e2d73d8663
- date added to LUP
- 2020-02-26 15:05:21
- date last changed
- 2022-04-18 21:03:13
@inbook{00ac8258-16ea-4637-b649-b3e2d73d8663,
abstract = {{<p>Carcinogen-DNA adducts result from the covalent interaction of electrophilic chemical carcinogens with nucleophilic sites in DNA. Some highly reactive genotoxic carcinogens are capable of directly binding to DNA but most carcinogens require metabolic activation. DNA adducts, if not repaired, can lead to mutations, and mutations in critical genes are a characteristic feature of tumors. Thus DNA adduct formation is considered a critical step in the initiation of carcinogenesis. DNA adducts formed in human tissues can be detected by a variety of sensitive techniques including <sup>32</sup>P-postlabeling, mass spectrometry, accelerator mass spectrometry, and immunoassays. Their detection and characterization in human tissues can provide clues on the etiology of human cancer.</p>}},
author = {{Krais, Annette M. and Singh, Rajinder and Arlt, Volker M.}},
booktitle = {{Encyclopedia of Cancer}},
editor = {{Boffetta, Paolo and Hainaut, Pierre}},
isbn = {{9780128124857}},
keywords = {{P-postlabeling; Accelerator; Adductomics; Aflatoxin B; Aristolochic acid; Benzo[a]pyrene; Biomarker of exposure; Chemical carcinogenesis; DNA adduct; Human biomonitoring; Immunoassay; Mass spectrometry; Xenobiotic metabolism}},
language = {{eng}},
pages = {{282--295}},
publisher = {{Elsevier}},
title = {{Carcinogen-DNA Adducts}},
url = {{http://dx.doi.org/10.1016/B978-0-12-801238-3.65219-4}},
doi = {{10.1016/B978-0-12-801238-3.65219-4}},
year = {{2019}},
}