Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

RIFM FRAGRANCE INGREDIENT SAFETY ASSESSMENT, l-Linalool, CAS Registry Number 126-91-0.

Api, A M ; Belsito, D ; Bhatia, S ; Bruze, Magnus LU ; Calow, P ; Dagli, M L ; Dekant, W ; Fryer, A D ; Kromidas, L and La Cava, S , et al. (2016) In Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 97. p.11-24
Abstract
The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined using a suitable read across analog to have the most conservative systemic exposure derived NO[A]EL of 36 mg/kg/day. A dermal 90-day subchronic toxicity study conducted in rats resulted in a MOE of 2250 while considering 14.4% absorption from skin contact and 100% from inhalation. A MOE of >100 is deemed acceptable.
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; and (Less)
publishing date
type
Contribution to journal
publication status
published
subject
in
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
volume
97
pages
11 - 24
publisher
Elsevier
external identifiers
  • pmid:26702985
  • scopus:84954215403
  • pmid:26702985
ISSN
1873-6351
DOI
10.1016/j.fct.2015.12.014
language
English
LU publication?
no
id
01a146b1-a2b1-47a8-9c9c-0de65577fcc8 (old id 8503713)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26702985?dopt=Abstract
date added to LUP
2016-04-04 09:15:31
date last changed
2022-04-11 14:03:20
@article{01a146b1-a2b1-47a8-9c9c-0de65577fcc8,
  abstract     = {{The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined using a suitable read across analog to have the most conservative systemic exposure derived NO[A]EL of 36 mg/kg/day. A dermal 90-day subchronic toxicity study conducted in rats resulted in a MOE of 2250 while considering 14.4% absorption from skin contact and 100% from inhalation. A MOE of >100 is deemed acceptable.}},
  author       = {{Api, A M and Belsito, D and Bhatia, S and Bruze, Magnus and Calow, P and Dagli, M L and Dekant, W and Fryer, A D and Kromidas, L and La Cava, S and Lalko, J F and Lapczynski, A and Liebler, D C and Miyachi, Y and Politano, V T and Ritacco, G and Salvito, D and Schultz, T W and Shen, J and Sipes, I G and Wall, B and Wilcox, D K}},
  issn         = {{1873-6351}},
  language     = {{eng}},
  pages        = {{11--24}},
  publisher    = {{Elsevier}},
  series       = {{Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association}},
  title        = {{RIFM FRAGRANCE INGREDIENT SAFETY ASSESSMENT, l-Linalool, CAS Registry Number 126-91-0.}},
  url          = {{http://dx.doi.org/10.1016/j.fct.2015.12.014}},
  doi          = {{10.1016/j.fct.2015.12.014}},
  volume       = {{97}},
  year         = {{2016}},
}