Physical activity reduces the risk of incident type 2 diabetes in general and in abdominally lean and obese men and women: the EPIC-InterAct Study
(2012) In Diabetologia 55(7). p.1944-1952- Abstract
- We examined the independent and combined associations of physical activity and obesity with incident type 2 diabetes in men and women. The InterAct case-cohort study consists of 12,403 incident type 2 diabetes cases and a randomly selected subcohort of 16,154 individuals, drawn from a total cohort of 340,234 participants with 3.99 million person-years of follow-up. Physical activity was assessed by a four-category index. Obesity was measured by BMI and waist circumference (WC). Associations between physical activity, obesity and case-ascertained incident type 2 diabetes were analysed by Cox regression after adjusting for educational level, smoking status, alcohol consumption and energy intake. In combined analyses, individuals were... (More)
- We examined the independent and combined associations of physical activity and obesity with incident type 2 diabetes in men and women. The InterAct case-cohort study consists of 12,403 incident type 2 diabetes cases and a randomly selected subcohort of 16,154 individuals, drawn from a total cohort of 340,234 participants with 3.99 million person-years of follow-up. Physical activity was assessed by a four-category index. Obesity was measured by BMI and waist circumference (WC). Associations between physical activity, obesity and case-ascertained incident type 2 diabetes were analysed by Cox regression after adjusting for educational level, smoking status, alcohol consumption and energy intake. In combined analyses, individuals were stratified according to physical activity level, BMI and WC. A one-category difference in physical activity (equivalent to approximately 460 and 365 kJ/day in men and women, respectively) was independently associated with a 13% (HR 0.87, 95% CI 0.80, 0.94) and 7% (HR 0.93, 95% CI 0.89, 0.98) relative reduction in the risk of type 2 diabetes in men and women, respectively. Lower levels of physical activity were associated with an increased risk of diabetes across all strata of BMI. Comparing inactive with active individuals, the HRs were 1.44 (95% CI 1.11, 1.87) and 1.38 (95% CI 1.17, 1.62) in abdominally lean and obese inactive men, respectively, and 1.57 (95% CI 1.19, 2.07) and 1.19 (95% CI 1.01, 1.39) in abdominally lean and obese inactive women, respectively. Physical activity is associated with a reduction in the risk of developing type 2 diabetes across BMI categories in men and women, as well as in abdominally lean and obese men and women. (Less)
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https://lup.lub.lu.se/record/2891069
- author
- organization
- publishing date
- 2012
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Abdominal obesity, Case-cohort study, Incident diabetes, Obesity, Physical activity
- in
- Diabetologia
- volume
- 55
- issue
- 7
- pages
- 1944 - 1952
- publisher
- Springer
- external identifiers
-
- wos:000305215200012
- scopus:84866420586
- pmid:22526603
- ISSN
- 1432-0428
- DOI
- 10.1007/s00125-012-2532-2
- language
- English
- LU publication?
- yes
- id
- 01ea718d-1a49-43f5-b0f8-7e233115efb3 (old id 2891069)
- date added to LUP
- 2016-04-01 10:31:41
- date last changed
- 2022-04-20 03:02:03
@article{01ea718d-1a49-43f5-b0f8-7e233115efb3,
abstract = {{We examined the independent and combined associations of physical activity and obesity with incident type 2 diabetes in men and women. The InterAct case-cohort study consists of 12,403 incident type 2 diabetes cases and a randomly selected subcohort of 16,154 individuals, drawn from a total cohort of 340,234 participants with 3.99 million person-years of follow-up. Physical activity was assessed by a four-category index. Obesity was measured by BMI and waist circumference (WC). Associations between physical activity, obesity and case-ascertained incident type 2 diabetes were analysed by Cox regression after adjusting for educational level, smoking status, alcohol consumption and energy intake. In combined analyses, individuals were stratified according to physical activity level, BMI and WC. A one-category difference in physical activity (equivalent to approximately 460 and 365 kJ/day in men and women, respectively) was independently associated with a 13% (HR 0.87, 95% CI 0.80, 0.94) and 7% (HR 0.93, 95% CI 0.89, 0.98) relative reduction in the risk of type 2 diabetes in men and women, respectively. Lower levels of physical activity were associated with an increased risk of diabetes across all strata of BMI. Comparing inactive with active individuals, the HRs were 1.44 (95% CI 1.11, 1.87) and 1.38 (95% CI 1.17, 1.62) in abdominally lean and obese inactive men, respectively, and 1.57 (95% CI 1.19, 2.07) and 1.19 (95% CI 1.01, 1.39) in abdominally lean and obese inactive women, respectively. Physical activity is associated with a reduction in the risk of developing type 2 diabetes across BMI categories in men and women, as well as in abdominally lean and obese men and women.}},
author = {{Ekelund, U. and Palla, L. and Brage, S. and Franks, Paul and Peters, T. and Balkau, B. and Diaz, M. J. T. and Huerta, J. M. and Agnoli, C. and Arriola, L. and Ardanaz, E. and Boeing, H. and Clavel-Chapelon, F. and Crowe, F. and Fagherazzi, G. and Groop, Leif and Hainaut, P. and Johnsen, N. Fons and Kaaks, R. and Khaw, K. T. and Key, T. J. and de Lauzon-Guillain, B. and May, A. and Monninkhof, E. and Navarro, C. and Nilsson, Peter and Ostergaard, J. Nautrup and Norat, T. and Overvad, K. and Palli, D. and Panico, S. and Redondo, M. L. and Ricceri, F. and Rolandsson, O. and Romaguera, D. and Romieu, I. and Sanchez Perez, M. J. and Slimani, N. and Spijkerman, A. and Teucher, B. and Tjonneland, A. and Travier, N. and Tumino, R. and Vos, W. and Vigl, M. and Sharp, S. and Langenberg, C. and Forouhi, N. and Riboli, E. and Feskens, E. and Wareham, N. J.}},
issn = {{1432-0428}},
keywords = {{Abdominal obesity; Case-cohort study; Incident diabetes; Obesity; Physical activity}},
language = {{eng}},
number = {{7}},
pages = {{1944--1952}},
publisher = {{Springer}},
series = {{Diabetologia}},
title = {{Physical activity reduces the risk of incident type 2 diabetes in general and in abdominally lean and obese men and women: the EPIC-InterAct Study}},
url = {{http://dx.doi.org/10.1007/s00125-012-2532-2}},
doi = {{10.1007/s00125-012-2532-2}},
volume = {{55}},
year = {{2012}},
}