Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Microglia in neurological diseases : A road map to brain-disease dependent-inflammatory response

Bachiller, Sara LU ; Jiménez-Ferrer, Itzia LU ; Paulus, Agnes LU ; Yang, Yiyi LU orcid ; Swanberg, Maria LU ; Deierborg, Tomas LU and Boza-Serrano, Antonio LU (2018) In Frontiers in Cellular Neuroscience 12.
Abstract

Microglia represent a specialized population of macrophages-like cells in the central nervous system (CNS) considered immune sentinels that are capable of orchestrating a potent inflammatory response. Microglia are also involved in synaptic organization, trophic neuronal support during development, phagocytosis of apoptotic cells in the developing brain, myelin turnover, control of neuronal excitability, phagocytic debris removal as well as brain protection and repair. Microglial response is pathology dependent and affects to immune, metabolic. In this review, we will shed light on microglial activation depending on the disease context and the influence of factors such as aging, environment or cell-to-cell interaction.

Please use this url to cite or link to this publication:
author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Alzheimer’s disease, Frontotemporal dementia, Inflammation, Microglia, Parkinson’s disease, Regional differences
in
Frontiers in Cellular Neuroscience
volume
12
article number
488
publisher
Frontiers Media S. A.
external identifiers
  • scopus:85059000005
ISSN
1662-5102
DOI
10.3389/fncel.2018.00488
language
English
LU publication?
yes
id
0200b3ea-e06d-45fd-9fbf-9b133570ee82
date added to LUP
2019-01-03 10:34:28
date last changed
2024-03-02 15:35:09
@article{0200b3ea-e06d-45fd-9fbf-9b133570ee82,
  abstract     = {{<p>Microglia represent a specialized population of macrophages-like cells in the central nervous system (CNS) considered immune sentinels that are capable of orchestrating a potent inflammatory response. Microglia are also involved in synaptic organization, trophic neuronal support during development, phagocytosis of apoptotic cells in the developing brain, myelin turnover, control of neuronal excitability, phagocytic debris removal as well as brain protection and repair. Microglial response is pathology dependent and affects to immune, metabolic. In this review, we will shed light on microglial activation depending on the disease context and the influence of factors such as aging, environment or cell-to-cell interaction.</p>}},
  author       = {{Bachiller, Sara and Jiménez-Ferrer, Itzia and Paulus, Agnes and Yang, Yiyi and Swanberg, Maria and Deierborg, Tomas and Boza-Serrano, Antonio}},
  issn         = {{1662-5102}},
  keywords     = {{Alzheimer’s disease; Frontotemporal dementia; Inflammation; Microglia; Parkinson’s disease; Regional differences}},
  language     = {{eng}},
  month        = {{12}},
  publisher    = {{Frontiers Media S. A.}},
  series       = {{Frontiers in Cellular Neuroscience}},
  title        = {{Microglia in neurological diseases : A road map to brain-disease dependent-inflammatory response}},
  url          = {{http://dx.doi.org/10.3389/fncel.2018.00488}},
  doi          = {{10.3389/fncel.2018.00488}},
  volume       = {{12}},
  year         = {{2018}},
}