Early Life Factors and Polycystic Ovary Syndrome in a Swedish Birth Cohort
(2023) In International Journal of Environmental Research and Public Health 20(22).- Abstract
Polycystic ovary syndrome (PCOS) is a medical condition with important consequences for women’s well-being and reproductive outcomes. Although the etiology of PCOS is not fully understood, there is increasing evidence of both genetic and environmental determinants, including development in early life. We studied a population of 977,637 singleton women born in in Sweden between 1973 and 1995, followed sometime between the age 15 and 40. The incidence of PCOS was measured using hospital register data during 2001–2012, complemented with information about the women’s, parents’ and sisters’ health and social characteristics from population and health care registers. Cox regression was used to study how PCOS is associated with... (More)
Polycystic ovary syndrome (PCOS) is a medical condition with important consequences for women’s well-being and reproductive outcomes. Although the etiology of PCOS is not fully understood, there is increasing evidence of both genetic and environmental determinants, including development in early life. We studied a population of 977,637 singleton women born in in Sweden between 1973 and 1995, followed sometime between the age 15 and 40. The incidence of PCOS was measured using hospital register data during 2001–2012, complemented with information about the women’s, parents’ and sisters’ health and social characteristics from population and health care registers. Cox regression was used to study how PCOS is associated with intergenerational factors, and a range of early life characteristics. 11,594 women in the study sample were diagnosed with PCOS during the follow-up period. The hazard rate for PCOS was increased 3-fold (HR 2.98, 95% CI 2.43–3.64) if the index woman’s mother had been diagnosed with PCOS, and with 1.5-fold (HR 1.51, 95% CI 1.39–1.63) if their mother had diabetes mellitus. We found associations of PCOS with lower (<7) one-minute Apgar score (HR 1.19, 95% CI 1.09–1.29) and with post-term birth (HR 1.19, 95% CI 1.13–1.26). Furthermore, heavy (10+ cigarettes/day) maternal smoking (HR 1.30, 95% CI 1.18–1.44) and maternal obesity (HR 1.90, 95% CI 1.62–2.36) were strongly associated with PCOS. This study finds support for the heritability and fetal origins of PCOS. Risk of PCOS could be reduced by further emphasizing the importance of maternal and early life health.
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- author
- Boldis, Beata Vivien LU ; Grünberger, Ilona ; Cederström, Agneta ; Björk, Jonas LU ; Nilsson, Anton LU and Helgertz, Jonas LU
- organization
- publishing date
- 2023-11
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- developmental origins of health, maternal diabetes, maternal smoking, polycystic ovary syndrome
- in
- International Journal of Environmental Research and Public Health
- volume
- 20
- issue
- 22
- article number
- 7083
- publisher
- MDPI AG
- external identifiers
-
- pmid:37998314
- scopus:85177659446
- ISSN
- 1661-7827
- DOI
- 10.3390/ijerph20227083
- project
- AIR Lund - Artificially Intelligent use of Registers
- language
- English
- LU publication?
- yes
- additional info
- Funding Information: This research was supported by Swedish Research Council for Health, Working Life and Welfare (FORTE grant number: 2018-00211, PI Grünberger). The funding bodies had no role in design of the study, data collection, analysis, interpretation of data or in writing the manuscript. Publisher Copyright: © 2023 by the authors.
- id
- 0216d485-8209-48ef-8ca8-65062df74ea3
- date added to LUP
- 2024-01-04 10:13:27
- date last changed
- 2024-04-19 06:28:59
@article{0216d485-8209-48ef-8ca8-65062df74ea3,
abstract = {{<p>Polycystic ovary syndrome (PCOS) is a medical condition with important consequences for women’s well-being and reproductive outcomes. Although the etiology of PCOS is not fully understood, there is increasing evidence of both genetic and environmental determinants, including development in early life. We studied a population of 977,637 singleton women born in in Sweden between 1973 and 1995, followed sometime between the age 15 and 40. The incidence of PCOS was measured using hospital register data during 2001–2012, complemented with information about the women’s, parents’ and sisters’ health and social characteristics from population and health care registers. Cox regression was used to study how PCOS is associated with intergenerational factors, and a range of early life characteristics. 11,594 women in the study sample were diagnosed with PCOS during the follow-up period. The hazard rate for PCOS was increased 3-fold (HR 2.98, 95% CI 2.43–3.64) if the index woman’s mother had been diagnosed with PCOS, and with 1.5-fold (HR 1.51, 95% CI 1.39–1.63) if their mother had diabetes mellitus. We found associations of PCOS with lower (<7) one-minute Apgar score (HR 1.19, 95% CI 1.09–1.29) and with post-term birth (HR 1.19, 95% CI 1.13–1.26). Furthermore, heavy (10+ cigarettes/day) maternal smoking (HR 1.30, 95% CI 1.18–1.44) and maternal obesity (HR 1.90, 95% CI 1.62–2.36) were strongly associated with PCOS. This study finds support for the heritability and fetal origins of PCOS. Risk of PCOS could be reduced by further emphasizing the importance of maternal and early life health.</p>}},
author = {{Boldis, Beata Vivien and Grünberger, Ilona and Cederström, Agneta and Björk, Jonas and Nilsson, Anton and Helgertz, Jonas}},
issn = {{1661-7827}},
keywords = {{developmental origins of health; maternal diabetes; maternal smoking; polycystic ovary syndrome}},
language = {{eng}},
number = {{22}},
publisher = {{MDPI AG}},
series = {{International Journal of Environmental Research and Public Health}},
title = {{Early Life Factors and Polycystic Ovary Syndrome in a Swedish Birth Cohort}},
url = {{http://dx.doi.org/10.3390/ijerph20227083}},
doi = {{10.3390/ijerph20227083}},
volume = {{20}},
year = {{2023}},
}