10 år med BDD-studien har gett bättre diabetesdiagnos hos barn : Studiens analysbatteri är nu klinisk rutin och kunskapen om olika diabetessjukdomar har ökat
(2018) In Läkartidningen 115(11). p.484-484- Abstract
The Swedish study Better Diabetes Diagnosis (BDD) has now been ongoing for ten years and detailed information and blood samples have been collected from more than 8000 children and adolescents with newly diagnosed diabetes. We have been able to demonstrate that by means of HLA diabetes antibodies and C-peptide the discrimination between type one and type 2 diabetes is improved. These analyses are therefore included in the clinical check-up for all children and adolescents in Sweden who are diagnosed with diabetes. Type 1 diabetes is by far the most prevalent type of diabetes among Swedish children and adolescents. Type 2 diabetes is still relatively rare in Sweden but it is urgent to obtain a correct diagnosis as the long-term prognosis... (More)
The Swedish study Better Diabetes Diagnosis (BDD) has now been ongoing for ten years and detailed information and blood samples have been collected from more than 8000 children and adolescents with newly diagnosed diabetes. We have been able to demonstrate that by means of HLA diabetes antibodies and C-peptide the discrimination between type one and type 2 diabetes is improved. These analyses are therefore included in the clinical check-up for all children and adolescents in Sweden who are diagnosed with diabetes. Type 1 diabetes is by far the most prevalent type of diabetes among Swedish children and adolescents. Type 2 diabetes is still relatively rare in Sweden but it is urgent to obtain a correct diagnosis as the long-term prognosis depends on a prompt pharmacological treatment. Monogenic diabetes (MODY) is also important to identify early. We therefore recommend that sequencing of MODY genes should be performed if an individual with newly-diagnosed diabetes is auto-antibody negative and has an HLA pattern associated with low risk for type 1 diabetes. However, despite these analytical tools it can be difficult to make the correct diabetes diagnosis initially. It is therefore prudent to re-evaluate the diabetes diagnosis after one year.
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- author
- Carlsson, Annelie LU ; Forsander, Gun ; Ivarsson, Sten LU ; Larsson, Helena Elding LU ; Lernmark, Åke LU ; Ludvigsson, Johnny ; Marcus, Claude ; Persson, Martina and Samuelsson, Ulf
- organization
- alternative title
- Better diabetes diagnoses in Sweden
- publishing date
- 2018
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Läkartidningen
- volume
- 115
- issue
- 11
- pages
- 1 pages
- publisher
- Swedish Medical Association
- external identifiers
-
- scopus:85044142187
- ISSN
- 0023-7205
- project
- Better Diabetes Diagnosis (BDD)
- language
- Swedish
- LU publication?
- yes
- id
- 03aba725-5fd9-442f-9943-be4218a63883
- alternative location
- http://lakartidningen.se/Klinik-och-vetenskap/Klinisk-oversikt/2018/03/10-ar-med-BDD-studien-har-gett-battre-diabetesdiagnos-hos-barn/
- date added to LUP
- 2018-04-09 12:29:15
- date last changed
- 2024-01-14 18:14:09
@article{03aba725-5fd9-442f-9943-be4218a63883, abstract = {{<p>The Swedish study Better Diabetes Diagnosis (BDD) has now been ongoing for ten years and detailed information and blood samples have been collected from more than 8000 children and adolescents with newly diagnosed diabetes. We have been able to demonstrate that by means of HLA diabetes antibodies and C-peptide the discrimination between type one and type 2 diabetes is improved. These analyses are therefore included in the clinical check-up for all children and adolescents in Sweden who are diagnosed with diabetes. Type 1 diabetes is by far the most prevalent type of diabetes among Swedish children and adolescents. Type 2 diabetes is still relatively rare in Sweden but it is urgent to obtain a correct diagnosis as the long-term prognosis depends on a prompt pharmacological treatment. Monogenic diabetes (MODY) is also important to identify early. We therefore recommend that sequencing of MODY genes should be performed if an individual with newly-diagnosed diabetes is auto-antibody negative and has an HLA pattern associated with low risk for type 1 diabetes. However, despite these analytical tools it can be difficult to make the correct diabetes diagnosis initially. It is therefore prudent to re-evaluate the diabetes diagnosis after one year.</p>}}, author = {{Carlsson, Annelie and Forsander, Gun and Ivarsson, Sten and Larsson, Helena Elding and Lernmark, Åke and Ludvigsson, Johnny and Marcus, Claude and Persson, Martina and Samuelsson, Ulf}}, issn = {{0023-7205}}, language = {{swe}}, number = {{11}}, pages = {{484--484}}, publisher = {{Swedish Medical Association}}, series = {{Läkartidningen}}, title = {{10 år med BDD-studien har gett bättre diabetesdiagnos hos barn : Studiens analysbatteri är nu klinisk rutin och kunskapen om olika diabetessjukdomar har ökat}}, url = {{http://lakartidningen.se/Klinik-och-vetenskap/Klinisk-oversikt/2018/03/10-ar-med-BDD-studien-har-gett-battre-diabetesdiagnos-hos-barn/}}, volume = {{115}}, year = {{2018}}, }