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10 år med BDD-studien har gett bättre diabetesdiagnos hos barn : Studiens analysbatteri är nu klinisk rutin och kunskapen om olika diabetessjukdomar har ökat

Carlsson, Annelie LU ; Forsander, Gun; Ivarsson, Sten LU ; Larsson, Helena Elding LU ; Lernmark, Åke LU ; Ludvigsson, Johnny; Marcus, Claude; Persson, Martina and Samuelsson, Ulf (2018) In Lakartidningen 115(11). p.484-484
Abstract

The Swedish study Better Diabetes Diagnosis (BDD) has now been ongoing for ten years and detailed information and blood samples have been collected from more than 8000 children and adolescents with newly diagnosed diabetes. We have been able to demonstrate that by means of HLA diabetes antibodies and C-peptide the discrimination between type one and type 2 diabetes is improved. These analyses are therefore included in the clinical check-up for all children and adolescents in Sweden who are diagnosed with diabetes. Type 1 diabetes is by far the most prevalent type of diabetes among Swedish children and adolescents. Type 2 diabetes is still relatively rare in Sweden but it is urgent to obtain a correct diagnosis as the long-term prognosis... (More)

The Swedish study Better Diabetes Diagnosis (BDD) has now been ongoing for ten years and detailed information and blood samples have been collected from more than 8000 children and adolescents with newly diagnosed diabetes. We have been able to demonstrate that by means of HLA diabetes antibodies and C-peptide the discrimination between type one and type 2 diabetes is improved. These analyses are therefore included in the clinical check-up for all children and adolescents in Sweden who are diagnosed with diabetes. Type 1 diabetes is by far the most prevalent type of diabetes among Swedish children and adolescents. Type 2 diabetes is still relatively rare in Sweden but it is urgent to obtain a correct diagnosis as the long-term prognosis depends on a prompt pharmacological treatment. Monogenic diabetes (MODY) is also important to identify early. We therefore recommend that sequencing of MODY genes should be performed if an individual with newly-diagnosed diabetes is auto-antibody negative and has an HLA pattern associated with low risk for type 1 diabetes. However, despite these analytical tools it can be difficult to make the correct diabetes diagnosis initially. It is therefore prudent to re-evaluate the diabetes diagnosis after one year.

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Please use this url to cite or link to this publication:
author
organization
alternative title
Better diabetes diagnoses in Sweden
publishing date
type
Contribution to journal
publication status
published
subject
in
Lakartidningen
volume
115
issue
11
pages
1 pages
publisher
Swedish Medical Association
external identifiers
  • scopus:85044142187
ISSN
0023-7205
language
Swedish
LU publication?
yes
id
03aba725-5fd9-442f-9943-be4218a63883
alternative location
http://lakartidningen.se/Klinik-och-vetenskap/Klinisk-oversikt/2018/03/10-ar-med-BDD-studien-har-gett-battre-diabetesdiagnos-hos-barn/
date added to LUP
2018-04-09 12:29:15
date last changed
2019-02-20 11:13:09
@article{03aba725-5fd9-442f-9943-be4218a63883,
  abstract     = {<p>The Swedish study Better Diabetes Diagnosis (BDD) has now been ongoing for ten years and detailed information and blood samples have been collected from more than 8000 children and adolescents with newly diagnosed diabetes. We have been able to demonstrate that by means of HLA diabetes antibodies and C-peptide the discrimination between type one and type 2 diabetes is improved. These analyses are therefore included in the clinical check-up for all children and adolescents in Sweden who are diagnosed with diabetes. Type 1 diabetes is by far the most prevalent type of diabetes among Swedish children and adolescents. Type 2 diabetes is still relatively rare in Sweden but it is urgent to obtain a correct diagnosis as the long-term prognosis depends on a prompt pharmacological treatment. Monogenic diabetes (MODY) is also important to identify early. We therefore recommend that sequencing of MODY genes should be performed if an individual with newly-diagnosed diabetes is auto-antibody negative and has an HLA pattern associated with low risk for type 1 diabetes. However, despite these analytical tools it can be difficult to make the correct diabetes diagnosis initially. It is therefore prudent to re-evaluate the diabetes diagnosis after one year.</p>},
  author       = {Carlsson, Annelie and Forsander, Gun and Ivarsson, Sten and Larsson, Helena Elding and Lernmark, Åke and Ludvigsson, Johnny and Marcus, Claude and Persson, Martina and Samuelsson, Ulf},
  issn         = {0023-7205},
  language     = {swe},
  number       = {11},
  pages        = {484--484},
  publisher    = {Swedish Medical Association},
  series       = {Lakartidningen},
  title        = {10 år med BDD-studien har gett bättre diabetesdiagnos hos barn : Studiens analysbatteri är nu klinisk rutin och kunskapen om olika diabetessjukdomar har ökat},
  volume       = {115},
  year         = {2018},
}