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Clinical recognition of frontotemporal dementia with right temporal predominance : a consensus statement from the International Working Group

Ulugut, Hulya ; Younes, Kyan ; Montembeault, Maxime ; Bertoux, Maxime ; Irish, Muireann ; Kumfor, Fiona ; Fumagalli, Giorgio G. ; Samanci, Bedia ; Illán-Gala, Ignacio and Thompson, Jennifer C. , et al. (2025) In Communications medicine 5(1).
Abstract

Accurate diagnosis of frontotemporal dementia (FTD) with right anterior temporal lobe (RATL) predominance remains challenging due to lack of clinical characterization, and standardized terminology. The recent research of the International Working Group (IWG) identified common symptoms but also unveiled broad terminologies lacking precision and operationalization, with risk of misdiagnoses, inappropriate referrals and poor clinical management. Based on the published evidence (91267 articles screened) and expert opinion (105 FTD specialists across 52 centers) by using the nominal group technique, the IWG delineates three primary domains of impairment causing behavioral, memory and language problems: (i) multimodal knowledge of non-verbal... (More)

Accurate diagnosis of frontotemporal dementia (FTD) with right anterior temporal lobe (RATL) predominance remains challenging due to lack of clinical characterization, and standardized terminology. The recent research of the International Working Group (IWG) identified common symptoms but also unveiled broad terminologies lacking precision and operationalization, with risk of misdiagnoses, inappropriate referrals and poor clinical management. Based on the published evidence (91267 articles screened) and expert opinion (105 FTD specialists across 52 centers) by using the nominal group technique, the IWG delineates three primary domains of impairment causing behavioral, memory and language problems: (i) multimodal knowledge of non-verbal information including people, living beings, landmarks, flavors/odors, sounds, bodily sensations, emotions and social cues; (ii) socioemotional behavior encompassing emotion expression, social response and motivation; and (iii) prioritization for focus on specific interests, hedonic valuation and personal preferences. This study establishes a consensus on clinical profile, phenotypic nomenclature, and future directions to enhance diagnostic precision and therapeutic interventions.

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published
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Communications medicine
volume
5
issue
1
article number
523
publisher
Nature Publishing Group
external identifiers
  • scopus:105025118071
ISSN
2730-664X
DOI
10.1038/s43856-025-01252-4
language
English
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yes
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Publisher Copyright: © The Author(s) 2025.
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04b1012a-54a9-4b13-a4b1-45795ac91885
date added to LUP
2025-12-29 06:43:07
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2025-12-30 10:43:55
@article{04b1012a-54a9-4b13-a4b1-45795ac91885,
  abstract     = {{<p>Accurate diagnosis of frontotemporal dementia (FTD) with right anterior temporal lobe (RATL) predominance remains challenging due to lack of clinical characterization, and standardized terminology. The recent research of the International Working Group (IWG) identified common symptoms but also unveiled broad terminologies lacking precision and operationalization, with risk of misdiagnoses, inappropriate referrals and poor clinical management. Based on the published evidence (91267 articles screened) and expert opinion (105 FTD specialists across 52 centers) by using the nominal group technique, the IWG delineates three primary domains of impairment causing behavioral, memory and language problems: (i) multimodal knowledge of non-verbal information including people, living beings, landmarks, flavors/odors, sounds, bodily sensations, emotions and social cues; (ii) socioemotional behavior encompassing emotion expression, social response and motivation; and (iii) prioritization for focus on specific interests, hedonic valuation and personal preferences. This study establishes a consensus on clinical profile, phenotypic nomenclature, and future directions to enhance diagnostic precision and therapeutic interventions.</p>}},
  author       = {{Ulugut, Hulya and Younes, Kyan and Montembeault, Maxime and Bertoux, Maxime and Irish, Muireann and Kumfor, Fiona and Fumagalli, Giorgio G. and Samanci, Bedia and Illán-Gala, Ignacio and Thompson, Jennifer C. and Santillo, Alexander Frizell and Englund, Elisabet and Landqvist Waldö, Maria and Riedl, Lina and Van den Stock, Jan and Vandenbulcke, Mathieu and Vandenberghe, Rik and Laforce, Robert and Ducharme, Simon and Pressman, Peter and Caramelli, Paulo and Cruz de Souza, Leonardo and Takada, Leonel T. and Gurvit, Hakan and Diehl-Schmid, Janine and Galimberti, Daniela and Pasquier, Florence and Weintraub, Sandra and Miller, Bruce L. and Sturm, Virginia E. and Whitwell, Jennifer L. and Boeve, Bradley and Rohrer, Jonathan D. and Piguet, Olivier and Gorno-Tempini, Maria Luisa and Josephs, Keith A. and Snowden, Julie and Rowe, James B. and Warren, Jason D. and Rankin, Katherine P. and Pijnenburg, Yolande}},
  issn         = {{2730-664X}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Communications medicine}},
  title        = {{Clinical recognition of frontotemporal dementia with right temporal predominance : a consensus statement from the International Working Group}},
  url          = {{http://dx.doi.org/10.1038/s43856-025-01252-4}},
  doi          = {{10.1038/s43856-025-01252-4}},
  volume       = {{5}},
  year         = {{2025}},
}