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Long-term cardiovascular risk in relation to birth weight and exposure to maternal diabetes mellitus.

Stuart, Andrea LU ; Amer-Wåhlin, Isis ; Persson, Jonas and Källén, Karin LU (2013) In International Journal of Cardiology 168(3). p.2653-2657
Abstract
BACKGROUND: Fetal exposure to maternal diabetes mellitus (DM) is associated with high birth weight, congenital heart malformations, childhood adiposity, DM, hypertension and dyslipidemia. The long term cardiovascular consequences of fetal exposure to maternal DM during pregnancy and high birth weight are not known. METHOD: All individuals born in Sweden 1973-1988 (n=1,551,603) were included in the study. The Swedish Medical Birth Register was merged with the Swedish Prescribed Drug Register. The association between offspring's adult consumption of cardiovascular medication and i) maternal DM during pregnancy and ii) birth weight were analyzed. Follow up time ranged between 17 and 36years. RESULTS: Offspring exposed to maternal DM in utero... (More)
BACKGROUND: Fetal exposure to maternal diabetes mellitus (DM) is associated with high birth weight, congenital heart malformations, childhood adiposity, DM, hypertension and dyslipidemia. The long term cardiovascular consequences of fetal exposure to maternal DM during pregnancy and high birth weight are not known. METHOD: All individuals born in Sweden 1973-1988 (n=1,551,603) were included in the study. The Swedish Medical Birth Register was merged with the Swedish Prescribed Drug Register. The association between offspring's adult consumption of cardiovascular medication and i) maternal DM during pregnancy and ii) birth weight were analyzed. Follow up time ranged between 17 and 36years. RESULTS: Offspring exposed to maternal DM in utero had an increased risk of non-malformation cardiovascular disease (NMCVD), odds ratio (OR) 1.46 (95% confidence interval (CI) 1.16-1.83). After also excluding offspring with insulin dependent DM, no increased risk of NMCVD was found, OR 1.19 (95% CI 0.92-1.55). No increased risk of NMCVD was found in offspring born large for gestational age, OR 1.02 (95% CI 0.96-1.08). An increased risk of NMCVD was found in offspring born small for gestational age, OR 1.29 (95% CI 1.24-1.35). CONCLUSIONS: Exposure to maternal DM during pregnancy was not associated with NMCVD in offspring at a maximum of 36years of follow up. Low birth weight was confirmed to be a risk factor for NMCVD while high birth weight was not. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Cardiology
volume
168
issue
3
pages
2653 - 2657
publisher
Elsevier
external identifiers
  • wos:000326184400147
  • pmid:23562336
  • scopus:84885625842
  • pmid:23562336
ISSN
0167-5273
DOI
10.1016/j.ijcard.2013.03.032
language
English
LU publication?
yes
id
050b6bb9-bfe4-44cd-a6cd-169e24314874 (old id 3734077)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23562336?dopt=Abstract
date added to LUP
2016-04-01 10:42:25
date last changed
2023-08-30 14:14:38
@article{050b6bb9-bfe4-44cd-a6cd-169e24314874,
  abstract     = {{BACKGROUND: Fetal exposure to maternal diabetes mellitus (DM) is associated with high birth weight, congenital heart malformations, childhood adiposity, DM, hypertension and dyslipidemia. The long term cardiovascular consequences of fetal exposure to maternal DM during pregnancy and high birth weight are not known. METHOD: All individuals born in Sweden 1973-1988 (n=1,551,603) were included in the study. The Swedish Medical Birth Register was merged with the Swedish Prescribed Drug Register. The association between offspring's adult consumption of cardiovascular medication and i) maternal DM during pregnancy and ii) birth weight were analyzed. Follow up time ranged between 17 and 36years. RESULTS: Offspring exposed to maternal DM in utero had an increased risk of non-malformation cardiovascular disease (NMCVD), odds ratio (OR) 1.46 (95% confidence interval (CI) 1.16-1.83). After also excluding offspring with insulin dependent DM, no increased risk of NMCVD was found, OR 1.19 (95% CI 0.92-1.55). No increased risk of NMCVD was found in offspring born large for gestational age, OR 1.02 (95% CI 0.96-1.08). An increased risk of NMCVD was found in offspring born small for gestational age, OR 1.29 (95% CI 1.24-1.35). CONCLUSIONS: Exposure to maternal DM during pregnancy was not associated with NMCVD in offspring at a maximum of 36years of follow up. Low birth weight was confirmed to be a risk factor for NMCVD while high birth weight was not.}},
  author       = {{Stuart, Andrea and Amer-Wåhlin, Isis and Persson, Jonas and Källén, Karin}},
  issn         = {{0167-5273}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{2653--2657}},
  publisher    = {{Elsevier}},
  series       = {{International Journal of Cardiology}},
  title        = {{Long-term cardiovascular risk in relation to birth weight and exposure to maternal diabetes mellitus.}},
  url          = {{http://dx.doi.org/10.1016/j.ijcard.2013.03.032}},
  doi          = {{10.1016/j.ijcard.2013.03.032}},
  volume       = {{168}},
  year         = {{2013}},
}