Galectin-3, a rising star in modulating microglia activation under conditions of neurodegeneration
(2022) In Cell Death and Disease 13(7).- Abstract
The advent of high-throughput single-cell transcriptomic analysis of microglia has revealed different phenotypes that are inherently associated with disease conditions. A common feature of some of these activated phenotypes is the upregulation of galectin-3. Representative examples of these phenotypes include disease-associated microglia (DAM) and white-associated microglia (WAM), whose role(s) in neuroprotection/neurotoxicity is a matter of high interest in the microglia community. In this review, we summarise the main findings that demonstrate the ability of galectin-3 to interact with key pattern recognition receptors, including, among others, TLR4 and TREM2 and the importance of galectin-3 in the regulation of microglia activation.... (More)
The advent of high-throughput single-cell transcriptomic analysis of microglia has revealed different phenotypes that are inherently associated with disease conditions. A common feature of some of these activated phenotypes is the upregulation of galectin-3. Representative examples of these phenotypes include disease-associated microglia (DAM) and white-associated microglia (WAM), whose role(s) in neuroprotection/neurotoxicity is a matter of high interest in the microglia community. In this review, we summarise the main findings that demonstrate the ability of galectin-3 to interact with key pattern recognition receptors, including, among others, TLR4 and TREM2 and the importance of galectin-3 in the regulation of microglia activation. Finally, we discuss increasing evidence supporting the involvement of this lectin in the main neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, multiple sclerosis, traumatic brain injury, and stroke.
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- author
- García-Revilla, Juan LU ; Boza-Serrano, Antonio LU ; Espinosa-Oliva, Ana M. ; Soto, Manuel Sarmiento ; Deierborg, Tomas LU ; Ruiz, Rocío ; de Pablos, Rocío M. ; Burguillos, Miguel Angel and Venero, Jose L.
- organization
- publishing date
- 2022-07
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Cell Death and Disease
- volume
- 13
- issue
- 7
- article number
- 628
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:85134532661
- pmid:35859075
- ISSN
- 2041-4889
- DOI
- 10.1038/s41419-022-05058-3
- language
- English
- LU publication?
- yes
- id
- 050b93f8-b031-4276-adda-2a4efce6428f
- date added to LUP
- 2022-09-26 14:57:25
- date last changed
- 2024-04-18 10:44:28
@article{050b93f8-b031-4276-adda-2a4efce6428f,
abstract = {{<p>The advent of high-throughput single-cell transcriptomic analysis of microglia has revealed different phenotypes that are inherently associated with disease conditions. A common feature of some of these activated phenotypes is the upregulation of galectin-3. Representative examples of these phenotypes include disease-associated microglia (DAM) and white-associated microglia (WAM), whose role(s) in neuroprotection/neurotoxicity is a matter of high interest in the microglia community. In this review, we summarise the main findings that demonstrate the ability of galectin-3 to interact with key pattern recognition receptors, including, among others, TLR4 and TREM2 and the importance of galectin-3 in the regulation of microglia activation. Finally, we discuss increasing evidence supporting the involvement of this lectin in the main neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, multiple sclerosis, traumatic brain injury, and stroke.</p>}},
author = {{García-Revilla, Juan and Boza-Serrano, Antonio and Espinosa-Oliva, Ana M. and Soto, Manuel Sarmiento and Deierborg, Tomas and Ruiz, Rocío and de Pablos, Rocío M. and Burguillos, Miguel Angel and Venero, Jose L.}},
issn = {{2041-4889}},
language = {{eng}},
number = {{7}},
publisher = {{Nature Publishing Group}},
series = {{Cell Death and Disease}},
title = {{Galectin-3, a rising star in modulating microglia activation under conditions of neurodegeneration}},
url = {{http://dx.doi.org/10.1038/s41419-022-05058-3}},
doi = {{10.1038/s41419-022-05058-3}},
volume = {{13}},
year = {{2022}},
}