Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Characterization of tumour-like inclusions in breast-mimicking phantoms using ultrasound optical tomography

Zabiliūtė-Karaliūnė, Akvilė LU ; Bukartė, Eglė LU ; Ruchkina, Maria LU ; Kinos, Adam LU ; Bengtsson, Alexander ; Hill, David LU ; Reistad, Nina LU orcid ; Rippe, Lars LU ; Swartling, Johannes LU and Dravecz, Gabriella , et al. (2025) In Scientific Reports 15(1).
Abstract

Ultrasound Optical Tomography (UOT) combines the high-resolution imaging capability of ultrasound with measurements of light absorption and scattering properties of human tissue. In this work, UOT working at 794.2 nm wavelength and equipped with a spectral hole burning filter was used to image through 5 cm thick tissue phantoms with embedded cubic 12 × 12 × 12 mm3 inclusions at a 2.5 cm depth. In contrast to earlier UOT works at tissue-relevant wavelengths, these inclusions have orders of magnitude lower absorption and actually mimic the optical properties of human breast tissue with various lesions. Phantoms with inclusions of increasing reduced scattering (inclusions 9.37–14.1 cm−1, background 7.83 and 8.5... (More)

Ultrasound Optical Tomography (UOT) combines the high-resolution imaging capability of ultrasound with measurements of light absorption and scattering properties of human tissue. In this work, UOT working at 794.2 nm wavelength and equipped with a spectral hole burning filter was used to image through 5 cm thick tissue phantoms with embedded cubic 12 × 12 × 12 mm3 inclusions at a 2.5 cm depth. In contrast to earlier UOT works at tissue-relevant wavelengths, these inclusions have orders of magnitude lower absorption and actually mimic the optical properties of human breast tissue with various lesions. Phantoms with inclusions of increasing reduced scattering (inclusions 9.37–14.1 cm−1, background 7.83 and 8.5 cm-1) and absorption (inclusions 0.061–0.086 cm−1, background 0.044 and 0.045 cm-1) coefficients were investigated. In the UOT images, the contrast-to-noise ratios varied between 3.87 ± 1.71 and 6.25 ± 2.96, and the inclusions could be easily identified by eye. This indicates that the UOT technique has the potential for spatially resolved imaging and optical data acquisition through at least 5 cm of soft tissue. Our findings suggest that UOT equipped with a spectral hole burning filter is a promising technique for breast tumour imaging as well as qualitative and quantitative characterization of their optical properties.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; ; ; ; ; and (Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scientific Reports
volume
15
issue
1
article number
32543
publisher
Nature Publishing Group
external identifiers
  • pmid:40954202
  • scopus:105016275285
ISSN
2045-2322
DOI
10.1038/s41598-025-18902-1
language
English
LU publication?
yes
id
05268e65-3e08-410f-a567-fae8f9a9b454
date added to LUP
2025-10-13 15:26:58
date last changed
2025-12-08 20:42:25
@article{05268e65-3e08-410f-a567-fae8f9a9b454,
  abstract     = {{<p>Ultrasound Optical Tomography (UOT) combines the high-resolution imaging capability of ultrasound with measurements of light absorption and scattering properties of human tissue. In this work, UOT working at 794.2 nm wavelength and equipped with a spectral hole burning filter was used to image through 5 cm thick tissue phantoms with embedded cubic 12 × 12 × 12 mm<sup>3</sup> inclusions at a 2.5 cm depth. In contrast to earlier UOT works at tissue-relevant wavelengths, these inclusions have orders of magnitude lower absorption and actually mimic the optical properties of human breast tissue with various lesions. Phantoms with inclusions of increasing reduced scattering (inclusions 9.37–14.1 cm<sup>−1</sup>, background 7.83 and 8.5 cm<sup>-1</sup>) and absorption (inclusions 0.061–0.086 cm<sup>−1</sup>, background 0.044 and 0.045 cm<sup>-1</sup>) coefficients were investigated. In the UOT images, the contrast-to-noise ratios varied between 3.87 ± 1.71 and 6.25 ± 2.96, and the inclusions could be easily identified by eye. This indicates that the UOT technique has the potential for spatially resolved imaging and optical data acquisition through at least 5 cm of soft tissue. Our findings suggest that UOT equipped with a spectral hole burning filter is a promising technique for breast tumour imaging as well as qualitative and quantitative characterization of their optical properties.</p>}},
  author       = {{Zabiliūtė-Karaliūnė, Akvilė and Bukartė, Eglė and Ruchkina, Maria and Kinos, Adam and Bengtsson, Alexander and Hill, David and Reistad, Nina and Rippe, Lars and Swartling, Johannes and Dravecz, Gabriella and Lengyel, Krisztián and Dustler, Magnus and Chaudhry, Nadia and Bakic, Predrag R. and Zackrisson, Sophia and Kröll, Stefan}},
  issn         = {{2045-2322}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Scientific Reports}},
  title        = {{Characterization of tumour-like inclusions in breast-mimicking phantoms using ultrasound optical tomography}},
  url          = {{http://dx.doi.org/10.1038/s41598-025-18902-1}},
  doi          = {{10.1038/s41598-025-18902-1}},
  volume       = {{15}},
  year         = {{2025}},
}