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Cellular dehydration acutely degrades mood mainly in women : A counterbalanced, crossover trial

Suh, Hyun Gyu ; Lieberman, Harris R. ; Jansen, Lisa T. ; Colburn, Abigail T. ; Adams, J. D. ; Seal, Adam D. ; Butts, Cory L. ; Kirkland, Tracie M. ; Melander, Olle LU and Vanhaecke, Tiphaine , et al. (2020) In British Journal of Nutrition
Abstract

It is unclear if mild-to-moderate dehydration independently affects mood without confounders like heat exposure or exercise. This study examined the acute effect of cellular dehydration on mood. Forty-nine adults (55 % female, age 39 (SD 8) years) were assigned to counterbalanced, crossover trials. Intracellular dehydration was induced with 2-h (0·1 ml/kg per min) 3 % hypertonic saline (HYPER) infusion or 0·9 % isotonic saline (ISO) as a control. Plasma osmolality increased in HYPER (pre 285 (SD 3), post 305 (SD 4) mmol/kg; P < 0·05) but remained unchanged in ISO (pre 285 (SD 3), post 288 (SD 3) mmol/kg; P > 0·05). Mood was assessed with the short version of the Profile of Mood States Questionnaire (POMS). The POMS sub-scale... (More)

It is unclear if mild-to-moderate dehydration independently affects mood without confounders like heat exposure or exercise. This study examined the acute effect of cellular dehydration on mood. Forty-nine adults (55 % female, age 39 (SD 8) years) were assigned to counterbalanced, crossover trials. Intracellular dehydration was induced with 2-h (0·1 ml/kg per min) 3 % hypertonic saline (HYPER) infusion or 0·9 % isotonic saline (ISO) as a control. Plasma osmolality increased in HYPER (pre 285 (SD 3), post 305 (SD 4) mmol/kg; P < 0·05) but remained unchanged in ISO (pre 285 (SD 3), post 288 (SD 3) mmol/kg; P > 0·05). Mood was assessed with the short version of the Profile of Mood States Questionnaire (POMS). The POMS sub-scale (confusion-bewilderment, depression-dejection, fatigue-inertia) increased in HYPER compared with ISO (P < 0·05). Total mood disturbance score (TMD) assessed by POMS increased from 10·3 (SD 0·9) to 16·6 (SD 1·7) in HYPER (P < 0·01), but not in ISO (P > 0·05). When TMD was stratified by sex, the increase in the HYPER trial was significant in females (P < 0·01) but not in males (P > 0·05). Following infusion, thirst and copeptin (surrogate for vasopressin) were also higher in females than in males (21·3 (SD 2·0), 14·1 (SD 1·4) pmol/l; P < 0·01) during HYPER. In conclusion, cellular dehydration acutely degraded specific aspects of mood mainly in women. The mechanisms underlying sex differences may be related to elevated thirst and vasopressin.

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Contribution to journal
publication status
epub
subject
keywords
Copeptin, Osmotic stimulation, Thirst, Underhydation, Vasopressin
in
British Journal of Nutrition
publisher
Cambridge University Press
external identifiers
  • scopus:85093929240
  • pmid:33077017
ISSN
0007-1145
DOI
10.1017/S0007114520003475
language
English
LU publication?
yes
id
054e6059-101e-45c3-8c03-cdbe57260ed2
date added to LUP
2020-11-12 10:29:00
date last changed
2021-01-06 07:58:29
@article{054e6059-101e-45c3-8c03-cdbe57260ed2,
  abstract     = {<p>It is unclear if mild-to-moderate dehydration independently affects mood without confounders like heat exposure or exercise. This study examined the acute effect of cellular dehydration on mood. Forty-nine adults (55 % female, age 39 (SD 8) years) were assigned to counterbalanced, crossover trials. Intracellular dehydration was induced with 2-h (0·1 ml/kg per min) 3 % hypertonic saline (HYPER) infusion or 0·9 % isotonic saline (ISO) as a control. Plasma osmolality increased in HYPER (pre 285 (SD 3), post 305 (SD 4) mmol/kg; P &lt; 0·05) but remained unchanged in ISO (pre 285 (SD 3), post 288 (SD 3) mmol/kg; P &gt; 0·05). Mood was assessed with the short version of the Profile of Mood States Questionnaire (POMS). The POMS sub-scale (confusion-bewilderment, depression-dejection, fatigue-inertia) increased in HYPER compared with ISO (P &lt; 0·05). Total mood disturbance score (TMD) assessed by POMS increased from 10·3 (SD 0·9) to 16·6 (SD 1·7) in HYPER (P &lt; 0·01), but not in ISO (P &gt; 0·05). When TMD was stratified by sex, the increase in the HYPER trial was significant in females (P &lt; 0·01) but not in males (P &gt; 0·05). Following infusion, thirst and copeptin (surrogate for vasopressin) were also higher in females than in males (21·3 (SD 2·0), 14·1 (SD 1·4) pmol/l; P &lt; 0·01) during HYPER. In conclusion, cellular dehydration acutely degraded specific aspects of mood mainly in women. The mechanisms underlying sex differences may be related to elevated thirst and vasopressin.</p>},
  author       = {Suh, Hyun Gyu and Lieberman, Harris R. and Jansen, Lisa T. and Colburn, Abigail T. and Adams, J. D. and Seal, Adam D. and Butts, Cory L. and Kirkland, Tracie M. and Melander, Olle and Vanhaecke, Tiphaine and Dolci, Alberto and Lemetais, Guillaume and Perrier, Erica T. and Kavouras, Stavros A.},
  issn         = {0007-1145},
  language     = {eng},
  month        = {10},
  publisher    = {Cambridge University Press},
  series       = {British Journal of Nutrition},
  title        = {Cellular dehydration acutely degrades mood mainly in women : A counterbalanced, crossover trial},
  url          = {http://dx.doi.org/10.1017/S0007114520003475},
  doi          = {10.1017/S0007114520003475},
  year         = {2020},
}