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Cellular dehydration acutely degrades mood mainly in women : A counterbalanced, crossover trial

Suh, Hyun Gyu ; Lieberman, Harris R. ; Jansen, Lisa T. ; Colburn, Abigail T. ; Adams, J. D. ; Seal, Adam D. ; Butts, Cory L. ; Kirkland, Tracie M. ; Melander, Olle LU orcid and Vanhaecke, Tiphaine , et al. (2021) In British Journal of Nutrition 125(10). p.1092-1100
Abstract

It is unclear if mild-to-moderate dehydration independently affects mood without confounders like heat exposure or exercise. This study examined the acute effect of cellular dehydration on mood. Forty-nine adults (55 % female, age 39 (SD 8) years) were assigned to counterbalanced, crossover trials. Intracellular dehydration was induced with 2-h (0·1 ml/kg per min) 3 % hypertonic saline (HYPER) infusion or 0·9 % isotonic saline (ISO) as a control. Plasma osmolality increased in HYPER (pre 285 (SD 3), post 305 (SD 4) mmol/kg; P < 0·05) but remained unchanged in ISO (pre 285 (SD 3), post 288 (SD 3) mmol/kg; P > 0·05). Mood was assessed with the short version of the Profile of Mood States Questionnaire (POMS). The POMS sub-scale... (More)

It is unclear if mild-to-moderate dehydration independently affects mood without confounders like heat exposure or exercise. This study examined the acute effect of cellular dehydration on mood. Forty-nine adults (55 % female, age 39 (SD 8) years) were assigned to counterbalanced, crossover trials. Intracellular dehydration was induced with 2-h (0·1 ml/kg per min) 3 % hypertonic saline (HYPER) infusion or 0·9 % isotonic saline (ISO) as a control. Plasma osmolality increased in HYPER (pre 285 (SD 3), post 305 (SD 4) mmol/kg; P < 0·05) but remained unchanged in ISO (pre 285 (SD 3), post 288 (SD 3) mmol/kg; P > 0·05). Mood was assessed with the short version of the Profile of Mood States Questionnaire (POMS). The POMS sub-scale (confusion-bewilderment, depression-dejection, fatigue-inertia) increased in HYPER compared with ISO (P < 0·05). Total mood disturbance score (TMD) assessed by POMS increased from 10·3 (SD 0·9) to 16·6 (SD 1·7) in HYPER (P < 0·01), but not in ISO (P > 0·05). When TMD was stratified by sex, the increase in the HYPER trial was significant in females (P < 0·01) but not in males (P > 0·05). Following infusion, thirst and copeptin (surrogate for vasopressin) were also higher in females than in males (21·3 (SD 2·0), 14·1 (SD 1·4) pmol/l; P < 0·01) during HYPER. In conclusion, cellular dehydration acutely degraded specific aspects of mood mainly in women. The mechanisms underlying sex differences may be related to elevated thirst and vasopressin.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Copeptin, Osmotic stimulation, Thirst, Underhydation, Vasopressin
in
British Journal of Nutrition
volume
125
issue
10
pages
9 pages
publisher
Cambridge University Press
external identifiers
  • pmid:33077017
  • scopus:85093929240
ISSN
0007-1145
DOI
10.1017/S0007114520003475
project
MOVING FROM BIOMARKERS TO MECHANISM ORIENTED PREVENTION OF CARDIOMETABOLIC DISEASE
language
English
LU publication?
yes
id
054e6059-101e-45c3-8c03-cdbe57260ed2
date added to LUP
2020-11-12 10:29:00
date last changed
2024-04-17 18:36:37
@article{054e6059-101e-45c3-8c03-cdbe57260ed2,
  abstract     = {{<p>It is unclear if mild-to-moderate dehydration independently affects mood without confounders like heat exposure or exercise. This study examined the acute effect of cellular dehydration on mood. Forty-nine adults (55 % female, age 39 (SD 8) years) were assigned to counterbalanced, crossover trials. Intracellular dehydration was induced with 2-h (0·1 ml/kg per min) 3 % hypertonic saline (HYPER) infusion or 0·9 % isotonic saline (ISO) as a control. Plasma osmolality increased in HYPER (pre 285 (SD 3), post 305 (SD 4) mmol/kg; P &lt; 0·05) but remained unchanged in ISO (pre 285 (SD 3), post 288 (SD 3) mmol/kg; P &gt; 0·05). Mood was assessed with the short version of the Profile of Mood States Questionnaire (POMS). The POMS sub-scale (confusion-bewilderment, depression-dejection, fatigue-inertia) increased in HYPER compared with ISO (P &lt; 0·05). Total mood disturbance score (TMD) assessed by POMS increased from 10·3 (SD 0·9) to 16·6 (SD 1·7) in HYPER (P &lt; 0·01), but not in ISO (P &gt; 0·05). When TMD was stratified by sex, the increase in the HYPER trial was significant in females (P &lt; 0·01) but not in males (P &gt; 0·05). Following infusion, thirst and copeptin (surrogate for vasopressin) were also higher in females than in males (21·3 (SD 2·0), 14·1 (SD 1·4) pmol/l; P &lt; 0·01) during HYPER. In conclusion, cellular dehydration acutely degraded specific aspects of mood mainly in women. The mechanisms underlying sex differences may be related to elevated thirst and vasopressin.</p>}},
  author       = {{Suh, Hyun Gyu and Lieberman, Harris R. and Jansen, Lisa T. and Colburn, Abigail T. and Adams, J. D. and Seal, Adam D. and Butts, Cory L. and Kirkland, Tracie M. and Melander, Olle and Vanhaecke, Tiphaine and Dolci, Alberto and Lemetais, Guillaume and Perrier, Erica T. and Kavouras, Stavros A.}},
  issn         = {{0007-1145}},
  keywords     = {{Copeptin; Osmotic stimulation; Thirst; Underhydation; Vasopressin}},
  language     = {{eng}},
  month        = {{05}},
  number       = {{10}},
  pages        = {{1092--1100}},
  publisher    = {{Cambridge University Press}},
  series       = {{British Journal of Nutrition}},
  title        = {{Cellular dehydration acutely degrades mood mainly in women : A counterbalanced, crossover trial}},
  url          = {{http://dx.doi.org/10.1017/S0007114520003475}},
  doi          = {{10.1017/S0007114520003475}},
  volume       = {{125}},
  year         = {{2021}},
}