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Expression of fibroblast activation protein and the clinicopathological relevance in distal cholangiocarcinoma

Byrling, Johannes LU ; Sasor, Agata LU ; Nilsson, Johan LU orcid ; Said Hilmersson, Katarzyna LU ; Andersson, Roland LU and Andersson, Bodil LU orcid (2020) In Scandinavian Journal of Gastroenterology 55(1). p.82-89
Abstract

Objectives: The current survival of patients with distal cholangiocarcinoma (dCCA) is poor. There is a need to develop new prognostic and predictive biomarkers to improve the survival of patients. Fibroblast activation protein (FAP) expression has been associated with survival in several solid malignancies. The goal of this study was to evaluate the expression pattern and prognostic significance of FAP in dCCA. Materials and methods: FAP expression was examined in 57 resected dCCA specimens and 28 paired lymph node metastasis specimens, as well as 10 benign bile ducts using immunohistochemistry. FAP expression was scored in the epithelial and stromal component of the dCCA specimens. The association between FAP expression and prognosis... (More)

Objectives: The current survival of patients with distal cholangiocarcinoma (dCCA) is poor. There is a need to develop new prognostic and predictive biomarkers to improve the survival of patients. Fibroblast activation protein (FAP) expression has been associated with survival in several solid malignancies. The goal of this study was to evaluate the expression pattern and prognostic significance of FAP in dCCA. Materials and methods: FAP expression was examined in 57 resected dCCA specimens and 28 paired lymph node metastasis specimens, as well as 10 benign bile ducts using immunohistochemistry. FAP expression was scored in the epithelial and stromal component of the dCCA specimens. The association between FAP expression and prognosis was evaluated using univariable and multivariable statistical modeling. Results: FAP expression was absent in the benign controls. FAP expression was evident in the epithelial 43 (75%) and stromal compartment 34 (60%) of dCCA. There was no association between epithelial or stromal FAP expression and clinicopathological factors. Epithelial FAP expression (HR 0.4 95% CI 0.20–0.78; p=.007) but not stromal FAP expression was significantly associated with better survival in univariable and multivariable analysis. Conclusions: FAP overexpression is evident in dCCA. There was a positive association between epithelial FAP expression and better survival which merits further evaluation.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Distal cholangiocarcinoma, fibroblast activation protein, immunohistochemistry, microenvironment, survival
in
Scandinavian Journal of Gastroenterology
volume
55
issue
1
pages
8 pages
publisher
Taylor & Francis
external identifiers
  • scopus:85077854878
  • pmid:31917931
ISSN
0036-5521
DOI
10.1080/00365521.2019.1708449
language
English
LU publication?
yes
id
05c00c53-d13f-4377-827a-490f42a17263
date added to LUP
2021-01-07 12:12:44
date last changed
2024-06-27 05:05:49
@article{05c00c53-d13f-4377-827a-490f42a17263,
  abstract     = {{<p>Objectives: The current survival of patients with distal cholangiocarcinoma (dCCA) is poor. There is a need to develop new prognostic and predictive biomarkers to improve the survival of patients. Fibroblast activation protein (FAP) expression has been associated with survival in several solid malignancies. The goal of this study was to evaluate the expression pattern and prognostic significance of FAP in dCCA. Materials and methods: FAP expression was examined in 57 resected dCCA specimens and 28 paired lymph node metastasis specimens, as well as 10 benign bile ducts using immunohistochemistry. FAP expression was scored in the epithelial and stromal component of the dCCA specimens. The association between FAP expression and prognosis was evaluated using univariable and multivariable statistical modeling. Results: FAP expression was absent in the benign controls. FAP expression was evident in the epithelial 43 (75%) and stromal compartment 34 (60%) of dCCA. There was no association between epithelial or stromal FAP expression and clinicopathological factors. Epithelial FAP expression (HR 0.4 95% CI 0.20–0.78; p=.007) but not stromal FAP expression was significantly associated with better survival in univariable and multivariable analysis. Conclusions: FAP overexpression is evident in dCCA. There was a positive association between epithelial FAP expression and better survival which merits further evaluation.</p>}},
  author       = {{Byrling, Johannes and Sasor, Agata and Nilsson, Johan and Said Hilmersson, Katarzyna and Andersson, Roland and Andersson, Bodil}},
  issn         = {{0036-5521}},
  keywords     = {{Distal cholangiocarcinoma; fibroblast activation protein; immunohistochemistry; microenvironment; survival}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{82--89}},
  publisher    = {{Taylor & Francis}},
  series       = {{Scandinavian Journal of Gastroenterology}},
  title        = {{Expression of fibroblast activation protein and the clinicopathological relevance in distal cholangiocarcinoma}},
  url          = {{http://dx.doi.org/10.1080/00365521.2019.1708449}},
  doi          = {{10.1080/00365521.2019.1708449}},
  volume       = {{55}},
  year         = {{2020}},
}