Dynamic susceptibility contrast perfusion MRI using phase-based venous output functions: : comparison with pseudo-continuous arterial spin labelling and assessment of contrast agent concentration in large veins.
Wirestam, Ronnie LU
; Lind, Emelie
LU
; Ahlgren, André
LU
; Ståhlberg, Freddy
LU
and Knutsson, Linda
LU
(2016)
In Magnetic Resonance Materials in Physics, Biology, and Medicine
29(6).
p.823-831
- Abstract
OBJECTIVES: Contrast agent (CA) relaxivities are generally not well established in vivo, and the relationship between frequency/phase shift and magnetic susceptibility might be a useful alternative for CA quantification.
MATERIALS AND METHODS: Twenty volunteers (25-84 years old) were investigated using test-retest pre-bolus dynamic susceptibility-contrast (DSC) magnetic resonance imaging (MRI). The pre-bolus phase-based venous output function (VOF) time integral was used for arterial input function (AIF) rescaling. Resulting cerebral blood flow (CBF) data for grey matter (GM) were compared with pseudo-continuous arterial spin labelling (ASL). During the main bolus CA passage, the apparent spatial shift (pixel shift) of the... (More)
OBJECTIVES: Contrast agent (CA) relaxivities are generally not well established in vivo, and the relationship between frequency/phase shift and magnetic susceptibility might be a useful alternative for CA quantification.
MATERIALS AND METHODS: Twenty volunteers (25-84 years old) were investigated using test-retest pre-bolus dynamic susceptibility-contrast (DSC) magnetic resonance imaging (MRI). The pre-bolus phase-based venous output function (VOF) time integral was used for arterial input function (AIF) rescaling. Resulting cerebral blood flow (CBF) data for grey matter (GM) were compared with pseudo-continuous arterial spin labelling (ASL). During the main bolus CA passage, the apparent spatial shift (pixel shift) of the superior sagittal sinus (seen in single-shot echo-planar imaging (EPI)) was converted to CA concentration and compared with conventional ΔR2*-based data and with a predicted phase-based VOF from the pre-bolus experiment.
RESULTS: The phase-based pre-bolus VOF resulted in a reasonable inter-individual GM CBF variability (coefficient of variation 28 %). Comparison with ASL CBF values implied a tissue R2*-relaxivity of 32 mM(-1) s(-1). Pixel-shift data at low concentrations (data not available at peak concentrations) were in reasonable agreement with the predicted phase-based VOF.
CONCLUSION: Susceptibility-induced phase shifts and pixel shifts are potentially useful for large-vein CA quantification. Previous predictions of a higher R2*-relaxivity in tissue than in blood were supported.
(Less)
- author
- Wirestam, Ronnie
LU
; Lind, Emelie
LU
; Ahlgren, André
LU
; Ståhlberg, Freddy
LU
and Knutsson, Linda
LU
- organization
- publishing date
- 2016-12
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Magnetic Resonance Materials in Physics, Biology, and Medicine
- volume
- 29
- issue
- 6
- pages
- 9 pages
- publisher
- Springer
- external identifiers
-
- scopus:84974831628
- wos:000389268000004
- pmid:27295051
- ISSN
- 1352-8661
- DOI
- 10.1007/s10334-016-0567-y
- project
- Optimisation and Validation of Dynamic Susceptibility Contrast MRI
- MRI brain perfusion quantification at 3 tesla using arterial spin labeling
- language
- English
- LU publication?
- yes
- id
- 06b9198e-24a4-411c-bf2f-90e23990c793
- date added to LUP
- 2016-06-21 23:07:49
- date last changed
- 2025-01-12 07:47:11
@article{06b9198e-24a4-411c-bf2f-90e23990c793,
abstract = {{<p>OBJECTIVES: Contrast agent (CA) relaxivities are generally not well established in vivo, and the relationship between frequency/phase shift and magnetic susceptibility might be a useful alternative for CA quantification.</p><p>MATERIALS AND METHODS: Twenty volunteers (25-84 years old) were investigated using test-retest pre-bolus dynamic susceptibility-contrast (DSC) magnetic resonance imaging (MRI). The pre-bolus phase-based venous output function (VOF) time integral was used for arterial input function (AIF) rescaling. Resulting cerebral blood flow (CBF) data for grey matter (GM) were compared with pseudo-continuous arterial spin labelling (ASL). During the main bolus CA passage, the apparent spatial shift (pixel shift) of the superior sagittal sinus (seen in single-shot echo-planar imaging (EPI)) was converted to CA concentration and compared with conventional ΔR2*-based data and with a predicted phase-based VOF from the pre-bolus experiment.</p><p>RESULTS: The phase-based pre-bolus VOF resulted in a reasonable inter-individual GM CBF variability (coefficient of variation 28 %). Comparison with ASL CBF values implied a tissue R2*-relaxivity of 32 mM(-1) s(-1). Pixel-shift data at low concentrations (data not available at peak concentrations) were in reasonable agreement with the predicted phase-based VOF.</p><p>CONCLUSION: Susceptibility-induced phase shifts and pixel shifts are potentially useful for large-vein CA quantification. Previous predictions of a higher R2*-relaxivity in tissue than in blood were supported.</p>}},
author = {{Wirestam, Ronnie and Lind, Emelie and Ahlgren, André and Ståhlberg, Freddy and Knutsson, Linda}},
issn = {{1352-8661}},
language = {{eng}},
number = {{6}},
pages = {{823--831}},
publisher = {{Springer}},
series = {{Magnetic Resonance Materials in Physics, Biology, and Medicine}},
title = {{Dynamic susceptibility contrast perfusion MRI using phase-based venous output functions: : comparison with pseudo-continuous arterial spin labelling and assessment of contrast agent concentration in large veins.}},
url = {{http://dx.doi.org/10.1007/s10334-016-0567-y}},
doi = {{10.1007/s10334-016-0567-y}},
volume = {{29}},
year = {{2016}},
}