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Activation of a Temporal Memory in Purkinje Cells by the mGluR7 Receptor.

Johansson, Fredrik LU ; Carlsson, Hannes A E; Rasmussen, Anders LU ; Yeo, Christopher H and Hesslow, Germund LU (2015) In Cell Reports 13(9). p.1741-1746
Abstract
Cerebellar Purkinje cells can learn to respond to a conditioned stimulus with an adaptively timed pause in firing. This response was usually ascribed to long-term depression of parallel fiber to Purkinje cell synapses but has recently been shown to be due to a previously unknown form of learning involving an intrinsic cellular timing mechanism. Here, we investigate how these responses are elicited. They are resistant to blockade of GABAergic inhibition, suggesting that they are caused by glutamate release rather than by a changed balance between GABA and glutamate. We show that the responses are abolished by antagonists of the mGlu7 receptor but not significantly affected by other glutamate antagonists. These results support the existence... (More)
Cerebellar Purkinje cells can learn to respond to a conditioned stimulus with an adaptively timed pause in firing. This response was usually ascribed to long-term depression of parallel fiber to Purkinje cell synapses but has recently been shown to be due to a previously unknown form of learning involving an intrinsic cellular timing mechanism. Here, we investigate how these responses are elicited. They are resistant to blockade of GABAergic inhibition, suggesting that they are caused by glutamate release rather than by a changed balance between GABA and glutamate. We show that the responses are abolished by antagonists of the mGlu7 receptor but not significantly affected by other glutamate antagonists. These results support the existence of a distinct learning mechanism, different from changes in synaptic strength. They also demonstrate in vivo post-synaptic inhibition mediated by glutamate and show that the mGlu7 receptor is involved in activating intrinsic temporal memory. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cell Reports
volume
13
issue
9
pages
1741 - 1746
publisher
Cell Press
external identifiers
  • PMID:26655894
  • WOS:000366047000002
  • Scopus:84947591422
ISSN
2211-1247
DOI
10.1016/j.celrep.2015.10.047
project
Cognition, Communication and Learning
language
English
LU publication?
yes
id
06f98347-a4fa-4701-aca0-98722fa8cc90 (old id 8505191)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26655894?dopt=Abstract
date added to LUP
2016-01-05 17:14:42
date last changed
2017-01-15 04:02:57
@article{06f98347-a4fa-4701-aca0-98722fa8cc90,
  abstract     = {Cerebellar Purkinje cells can learn to respond to a conditioned stimulus with an adaptively timed pause in firing. This response was usually ascribed to long-term depression of parallel fiber to Purkinje cell synapses but has recently been shown to be due to a previously unknown form of learning involving an intrinsic cellular timing mechanism. Here, we investigate how these responses are elicited. They are resistant to blockade of GABAergic inhibition, suggesting that they are caused by glutamate release rather than by a changed balance between GABA and glutamate. We show that the responses are abolished by antagonists of the mGlu7 receptor but not significantly affected by other glutamate antagonists. These results support the existence of a distinct learning mechanism, different from changes in synaptic strength. They also demonstrate in vivo post-synaptic inhibition mediated by glutamate and show that the mGlu7 receptor is involved in activating intrinsic temporal memory.},
  author       = {Johansson, Fredrik and Carlsson, Hannes A E and Rasmussen, Anders and Yeo, Christopher H and Hesslow, Germund},
  issn         = {2211-1247},
  language     = {eng},
  number       = {9},
  pages        = {1741--1746},
  publisher    = {Cell Press},
  series       = {Cell Reports},
  title        = {Activation of a Temporal Memory in Purkinje Cells by the mGluR7 Receptor.},
  url          = {http://dx.doi.org/10.1016/j.celrep.2015.10.047},
  volume       = {13},
  year         = {2015},
}