Advanced

Coronary flow and reactivity, but not arrhythmia vulnerability, are affected by cardioplegia during cardiopulmonary bypass surgery of piglets

Liuba, P. LU ; Johansson, Sune LU ; Pesonen, E. LU ; Higgins, Thomas; Forslid, A. LU ; Kornerup-Hansen, Axel and Perez De Sa, V. LU (2011) 45th Annual Meeting of the European Paediatric Cardiology In Cardiology in the Young 21(S1). p.70-70
Abstract
Introduction: Cardiopulmonary bypass (CPB) surgery remains associated with significant cardiovascular morbidity in both pediatric and adult patients but the mechanisms are not fully clarified. Abnormalities in coronary flow and function have beensuggested to play an important role. A few prior studies suggested protective effects on coronary and myocardial function by short intravenous (i.v.) infusion of cyclosporine A prior to CPB surgery. Methods: Barrier-bred piglets (10-12 kg, n=20) were subjected to CPB with (n=10) or without (n=10) antegrade administration for 20 minutes of cardioplegic solution. Prior to surgery, half of animals from each group received 10-minute i.v. infusion of 100 mg/kg cyclosporine A. Left anterior descending... (More)
Introduction: Cardiopulmonary bypass (CPB) surgery remains associated with significant cardiovascular morbidity in both pediatric and adult patients but the mechanisms are not fully clarified. Abnormalities in coronary flow and function have beensuggested to play an important role. A few prior studies suggested protective effects on coronary and myocardial function by short intravenous (i.v.) infusion of cyclosporine A prior to CPB surgery. Methods: Barrier-bred piglets (10-12 kg, n=20) were subjected to CPB with (n=10) or without (n=10) antegrade administration for 20 minutes of cardioplegic solution. Prior to surgery, half of animals from each group received 10-minute i.v. infusion of 100 mg/kg cyclosporine A. Left anterior descending coronary flow velocity responses to adenosine, serotonin, and atrial pacing, as well as left ventricular function and postsurgical vulnerability to atrial fibrillation (Afib) were assessed by intracoronary Doppler, epicardial echocardiography, and in vivo electrophysiological study, respectively. Results: Coronary peak flow velocity (cPFV) rose significantly after surgery, especially in cardioplegia group (p0.4). There was no difference in systolic myocardial function between groups at any timepoint. Conclusions: Cardioplegia during CPB surgery of piglets was associated with profound abnormalities in coronary vasomotor tone and receptor-related flow regulation, whereas arrhythmia vulnerability appeared to be comparable with that in non-cardioplegia group. In this study, intracoronary pretreatment with cyclosporine had no observable protective effect on coronary circulation or arrhythmia vulnerability after CPB surgery. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cyclosporin, serotonin, adenosine, cyclosporin A, receptor, cardioplegic agent, cardioplegia, bypass surgery, Japanese (people), coronary artery blood flow, cardiopulmonary bypass, heart arrhythmia, society, piglet, cardiology, heart surgery, pediatric cardiology, surgery, flow rate, heart atrium pacing, heart function, infusion, morbidity, heart left ventricle function, atrial fibrillation, adult, patient, peak expiratory flow, echocardiography, intravenous drug administration
in
Cardiology in the Young
volume
21
issue
S1
pages
70 - 70
publisher
Cambridge University Press
conference name
45th Annual Meeting of the European Paediatric Cardiology
ISSN
1467-1107
DOI
10.1017/S104795111100028X
language
English
LU publication?
yes
id
0715d3de-dfde-48f1-bf5c-c2be32998651
date added to LUP
2017-07-21 10:25:41
date last changed
2017-08-08 16:19:49
@misc{0715d3de-dfde-48f1-bf5c-c2be32998651,
  abstract     = {Introduction: Cardiopulmonary bypass (CPB) surgery remains associated with significant cardiovascular morbidity in both pediatric and adult patients but the mechanisms are not fully clarified. Abnormalities in coronary flow and function have beensuggested to play an important role. A few prior studies suggested protective effects on coronary and myocardial function by short intravenous (i.v.) infusion of cyclosporine A prior to CPB surgery. Methods: Barrier-bred piglets (10-12 kg, n=20) were subjected to CPB with (n=10) or without (n=10) antegrade administration for 20 minutes of cardioplegic solution. Prior to surgery, half of animals from each group received 10-minute i.v. infusion of 100 mg/kg cyclosporine A. Left anterior descending coronary flow velocity responses to adenosine, serotonin, and atrial pacing, as well as left ventricular function and postsurgical vulnerability to atrial fibrillation (Afib) were assessed by intracoronary Doppler, epicardial echocardiography, and in vivo electrophysiological study, respectively. Results: Coronary peak flow velocity (cPFV) rose significantly after surgery, especially in cardioplegia group (p0.4). There was no difference in systolic myocardial function between groups at any timepoint. Conclusions: Cardioplegia during CPB surgery of piglets was associated with profound abnormalities in coronary vasomotor tone and receptor-related flow regulation, whereas arrhythmia vulnerability appeared to be comparable with that in non-cardioplegia group. In this study, intracoronary pretreatment with cyclosporine had no observable protective effect on coronary circulation or arrhythmia vulnerability after CPB surgery.},
  articleno    = {P-47},
  author       = {Liuba, P. and Johansson, Sune and Pesonen, E. and Higgins, Thomas and Forslid, A. and Kornerup-Hansen, Axel and Perez De Sa, V.},
  issn         = {1467-1107},
  keyword      = {cyclosporin,serotonin,adenosine,cyclosporin A,receptor,cardioplegic agent,cardioplegia,bypass surgery,Japanese (people),coronary artery blood flow,cardiopulmonary bypass,heart arrhythmia,society,piglet,cardiology,heart surgery,pediatric cardiology,surgery,flow rate,heart atrium pacing,heart function,infusion,morbidity,heart left ventricle function,atrial fibrillation,adult,patient,peak expiratory flow,echocardiography,intravenous drug administration},
  language     = {eng},
  month        = {05},
  note         = {Conference Abstract},
  number       = {S1},
  pages        = {70--70},
  publisher    = {Cambridge University Press},
  series       = {Cardiology in the Young},
  title        = {Coronary flow and reactivity, but not arrhythmia vulnerability, are affected by cardioplegia during cardiopulmonary bypass surgery of piglets},
  url          = {http://dx.doi.org/10.1017/S104795111100028X},
  volume       = {21},
  year         = {2011},
}