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Rapid and Green Separation of Mono- and Diesters of Monochloropropanediols by Ultrahigh Performance Supercritical Fluid Chromatography-Mass Spectrometry Using Neat Carbon Dioxide as a Mobile Phase

Jumaah, Firas LU ; JeÌdrkiewicz, Renata; Gromadzka, Justyna; Namieśnik, Jacek; Essén, Sofia LU ; Turner, Charlotta LU and Sandahl, Margareta LU (2017) In Journal of Agricultural and Food Chemistry 65(37). p.8220-8228
Abstract

This study demonstrates the effect of column selectivity and density of supercritical carbon dioxide (SC-CO2) on the separation of monochloropropanediol (MCPD) esters, known as food toxicants, using SC-CO2 without addition of cosolvent in ultrahigh performance supercritical fluid chromatography-mass spectrometry (UHPSFC-MS). This study shows that over 20 2-monochloropropanediol (2-MCPD) and 3-monochloropropanediol (3-MCPD) mono- and diesters are separated on a 2-picolylamine column in less than 12 min. The presence and position of a hydroxyl group in the structure, the number of unsaturated bonds, and the acyl chain length play a significant role in the separation of MCPD esters. The flow rate, backpressure, and... (More)

This study demonstrates the effect of column selectivity and density of supercritical carbon dioxide (SC-CO2) on the separation of monochloropropanediol (MCPD) esters, known as food toxicants, using SC-CO2 without addition of cosolvent in ultrahigh performance supercritical fluid chromatography-mass spectrometry (UHPSFC-MS). This study shows that over 20 2-monochloropropanediol (2-MCPD) and 3-monochloropropanediol (3-MCPD) mono- and diesters are separated on a 2-picolylamine column in less than 12 min. The presence and position of a hydroxyl group in the structure, the number of unsaturated bonds, and the acyl chain length play a significant role in the separation of MCPD esters. The flow rate, backpressure, and column oven temperature, which affect the density of the mobile phase, were shown to have a substantial impact on retention, efficiency, and selectivity. The developed method was successfully applied for the determination of MCPD esters in refined oils and showed a close to excellent green analysis score using the Analytical Eco-Scale.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
2-MCPD esters, 3-MCPD esters, chloropropanol, mass spectrometry, method development, orthogonal column screening, SFC, UPC
in
Journal of Agricultural and Food Chemistry
volume
65
issue
37
pages
9 pages
publisher
The American Chemical Society
external identifiers
  • scopus:85029671791
ISSN
0021-8561
DOI
10.1021/acs.jafc.7b02857
language
English
LU publication?
yes
id
07335dd8-fa43-4c18-8226-35e61d822c1f
date added to LUP
2017-10-05 13:44:09
date last changed
2018-06-24 05:17:20
@article{07335dd8-fa43-4c18-8226-35e61d822c1f,
  abstract     = {<p>This study demonstrates the effect of column selectivity and density of supercritical carbon dioxide (SC-CO<sub>2</sub>) on the separation of monochloropropanediol (MCPD) esters, known as food toxicants, using SC-CO<sub>2</sub> without addition of cosolvent in ultrahigh performance supercritical fluid chromatography-mass spectrometry (UHPSFC-MS). This study shows that over 20 2-monochloropropanediol (2-MCPD) and 3-monochloropropanediol (3-MCPD) mono- and diesters are separated on a 2-picolylamine column in less than 12 min. The presence and position of a hydroxyl group in the structure, the number of unsaturated bonds, and the acyl chain length play a significant role in the separation of MCPD esters. The flow rate, backpressure, and column oven temperature, which affect the density of the mobile phase, were shown to have a substantial impact on retention, efficiency, and selectivity. The developed method was successfully applied for the determination of MCPD esters in refined oils and showed a close to excellent green analysis score using the Analytical Eco-Scale.</p>},
  author       = {Jumaah, Firas and JeÌdrkiewicz, Renata and Gromadzka, Justyna and Namieśnik, Jacek and Essén, Sofia and Turner, Charlotta and Sandahl, Margareta},
  issn         = {0021-8561},
  keyword      = {2-MCPD esters,3-MCPD esters,chloropropanol,mass spectrometry,method development,orthogonal column screening,SFC,UPC},
  language     = {eng},
  month        = {09},
  number       = {37},
  pages        = {8220--8228},
  publisher    = {The American Chemical Society},
  series       = {Journal of Agricultural and Food Chemistry},
  title        = {Rapid and Green Separation of Mono- and Diesters of Monochloropropanediols by Ultrahigh Performance Supercritical Fluid Chromatography-Mass Spectrometry Using Neat Carbon Dioxide as a Mobile Phase},
  url          = {http://dx.doi.org/10.1021/acs.jafc.7b02857},
  volume       = {65},
  year         = {2017},
}