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Memory trace and timing mechanism localized to cerebellar Purkinje cells

Johansson, Fredrik LU ; Jirenhed, Dan-Anders LU ; Rasmussen, Anders LU ; Zucca, Riccardo LU and Hesslow, Germund LU (2014) In Proceedings of the National Academy of Sciences 111(41). p.14930-14934
Abstract
The standard view of the mechanisms underlying learning is that they involve strengthening or weakening synaptic connections. Learned response timing is thought to combine such plasticity with temporally patterned inputs to the neuron. We show here that a cerebellar Purkinje cell in a ferret can learn to respond to a specific input with a temporal pattern of activity consisting of temporally specific increases and decreases in firing over hundreds of milliseconds without a temporally patterned input. Training Purkinje cells with direct stimulation of immediate afferents, the parallel fibers, and pharmacological blocking of interneurons shows that the timing mechanism is intrinsic to the cell itself. Purkinje cells can learn to respond not... (More)
The standard view of the mechanisms underlying learning is that they involve strengthening or weakening synaptic connections. Learned response timing is thought to combine such plasticity with temporally patterned inputs to the neuron. We show here that a cerebellar Purkinje cell in a ferret can learn to respond to a specific input with a temporal pattern of activity consisting of temporally specific increases and decreases in firing over hundreds of milliseconds without a temporally patterned input. Training Purkinje cells with direct stimulation of immediate afferents, the parallel fibers, and pharmacological blocking of interneurons shows that the timing mechanism is intrinsic to the cell itself. Purkinje cells can learn to respond not only with increased or decreased firing but also with an adaptively timed activity pattern. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Proceedings of the National Academy of Sciences
volume
111
issue
41
pages
14930 - 14934
publisher
National Acad Sciences
external identifiers
  • pmid:25267641
  • wos:000342922000071
  • scopus:84907889404
ISSN
1091-6490
DOI
10.1073/pnas.1415371111
project
Cognition, Communication and Learning
language
English
LU publication?
yes
id
078c1bd9-4d92-4709-b170-9c61cc9ab73a (old id 4456437)
date added to LUP
2014-11-10 06:59:06
date last changed
2017-03-26 03:14:33
@article{078c1bd9-4d92-4709-b170-9c61cc9ab73a,
  abstract     = {The standard view of the mechanisms underlying learning is that they involve strengthening or weakening synaptic connections. Learned response timing is thought to combine such plasticity with temporally patterned inputs to the neuron. We show here that a cerebellar Purkinje cell in a ferret can learn to respond to a specific input with a temporal pattern of activity consisting of temporally specific increases and decreases in firing over hundreds of milliseconds without a temporally patterned input. Training Purkinje cells with direct stimulation of immediate afferents, the parallel fibers, and pharmacological blocking of interneurons shows that the timing mechanism is intrinsic to the cell itself. Purkinje cells can learn to respond not only with increased or decreased firing but also with an adaptively timed activity pattern.},
  author       = {Johansson, Fredrik and Jirenhed, Dan-Anders and Rasmussen, Anders and Zucca, Riccardo and Hesslow, Germund},
  issn         = {1091-6490},
  language     = {eng},
  number       = {41},
  pages        = {14930--14934},
  publisher    = {National Acad Sciences},
  series       = {Proceedings of the National Academy of Sciences},
  title        = {Memory trace and timing mechanism localized to cerebellar Purkinje cells},
  url          = {http://dx.doi.org/10.1073/pnas.1415371111},
  volume       = {111},
  year         = {2014},
}