Memory trace and timing mechanism localized to cerebellar Purkinje cells
Johansson, Fredrik LU ; Jirenhed, Dan-Anders LU ; Rasmussen, Anders LU
; Zucca, Riccardo
LU
and Hesslow, Germund
LU
(2014)
In Proceedings of the National Academy of Sciences
111(41).
p.14930-14934
- Abstract
- The standard view of the mechanisms underlying learning is that they involve strengthening or weakening synaptic connections. Learned response timing is thought to combine such plasticity with temporally patterned inputs to the neuron. We show here that a cerebellar Purkinje cell in a ferret can learn to respond to a specific input with a temporal pattern of activity consisting of temporally specific increases and decreases in firing over hundreds of milliseconds without a temporally patterned input. Training Purkinje cells with direct stimulation of immediate afferents, the parallel fibers, and pharmacological blocking of interneurons shows that the timing mechanism is intrinsic to the cell itself. Purkinje cells can learn to respond not... (More)
- The standard view of the mechanisms underlying learning is that they involve strengthening or weakening synaptic connections. Learned response timing is thought to combine such plasticity with temporally patterned inputs to the neuron. We show here that a cerebellar Purkinje cell in a ferret can learn to respond to a specific input with a temporal pattern of activity consisting of temporally specific increases and decreases in firing over hundreds of milliseconds without a temporally patterned input. Training Purkinje cells with direct stimulation of immediate afferents, the parallel fibers, and pharmacological blocking of interneurons shows that the timing mechanism is intrinsic to the cell itself. Purkinje cells can learn to respond not only with increased or decreased firing but also with an adaptively timed activity pattern. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4456437
- author
- Johansson, Fredrik
LU
; Jirenhed, Dan-Anders
LU
; Rasmussen, Anders
LU
; Zucca, Riccardo
LU
and Hesslow, Germund
LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Proceedings of the National Academy of Sciences
- volume
- 111
- issue
- 41
- pages
- 14930 - 14934
- publisher
- National Academy of Sciences
- external identifiers
-
- pmid:25267641
- wos:000342922000071
- scopus:84907889404
- pmid:25267641
- ISSN
- 1091-6490
- DOI
- 10.1073/pnas.1415371111
- project
- Thinking in Time: Cognition, Communication and Learning
- language
- English
- LU publication?
- yes
- id
- 078c1bd9-4d92-4709-b170-9c61cc9ab73a (old id 4456437)
- date added to LUP
- 2016-04-01 10:37:40
- date last changed
- 2022-05-16 12:08:51
@article{078c1bd9-4d92-4709-b170-9c61cc9ab73a,
abstract = {{The standard view of the mechanisms underlying learning is that they involve strengthening or weakening synaptic connections. Learned response timing is thought to combine such plasticity with temporally patterned inputs to the neuron. We show here that a cerebellar Purkinje cell in a ferret can learn to respond to a specific input with a temporal pattern of activity consisting of temporally specific increases and decreases in firing over hundreds of milliseconds without a temporally patterned input. Training Purkinje cells with direct stimulation of immediate afferents, the parallel fibers, and pharmacological blocking of interneurons shows that the timing mechanism is intrinsic to the cell itself. Purkinje cells can learn to respond not only with increased or decreased firing but also with an adaptively timed activity pattern.}},
author = {{Johansson, Fredrik and Jirenhed, Dan-Anders and Rasmussen, Anders and Zucca, Riccardo and Hesslow, Germund}},
issn = {{1091-6490}},
language = {{eng}},
number = {{41}},
pages = {{14930--14934}},
publisher = {{National Academy of Sciences}},
series = {{Proceedings of the National Academy of Sciences}},
title = {{Memory trace and timing mechanism localized to cerebellar Purkinje cells}},
url = {{http://dx.doi.org/10.1073/pnas.1415371111}},
doi = {{10.1073/pnas.1415371111}},
volume = {{111}},
year = {{2014}},
}