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Serum levels of thyrotropin are decreased by oral calcium in healthy subjects but not in patients with primary hyperparathyroidism

Bergenfelz, A LU and Ahrén, B LU (1994) In Hormone Research 42(6). p.7-273
Abstract

It has been suggested that calcium changes the set point of the pituitary thyroid feedback. It is not known, however, if small and slow changes of calcium and/or parathyroid hormone (PTH) within the physiological range influence the serum levels of thyrotropin (TSH) and thyroid hormones in healthy subjects or patients with primary hyperparathyroidism (pHPT). Nine healthy subjects and nine patients with pHPT were therefore investigated with an oral calcium load test. The patients were investigated before and 4 days after operation. During the test, serum levels of ionized calcium increased and serum levels of intact PTH decreased in both healthy subjects and patients pre- and postoperatively (p < 0.001). Furthermore, in patients, the... (More)

It has been suggested that calcium changes the set point of the pituitary thyroid feedback. It is not known, however, if small and slow changes of calcium and/or parathyroid hormone (PTH) within the physiological range influence the serum levels of thyrotropin (TSH) and thyroid hormones in healthy subjects or patients with primary hyperparathyroidism (pHPT). Nine healthy subjects and nine patients with pHPT were therefore investigated with an oral calcium load test. The patients were investigated before and 4 days after operation. During the test, serum levels of ionized calcium increased and serum levels of intact PTH decreased in both healthy subjects and patients pre- and postoperatively (p < 0.001). Furthermore, in patients, the suppressibility of serum levels of PTH by calcium increased postoperatively (p < 0.05). Serum levels of TSH decreased during the oral calcium load in healthy subjects (p < 0.01) but not in patients, whereas the serum levels of thyroid hormones did not change. It is concluded that oral calcium influences TSH secretion in healthy humans but not in patients with pHPT.

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published
subject
keywords
Aged, Calcium, Case-Control Studies, Humans, Hyperparathyroidism, Middle Aged, Parathyroid Hormone, Pituitary Gland, Thyroid Hormones, Thyrotropin, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
in
Hormone Research
volume
42
issue
6
pages
7 - 273
publisher
Karger
external identifiers
  • scopus:0028652321
ISSN
0301-0163
DOI
10.1159/000184208
language
English
LU publication?
yes
id
08378271-48a7-4272-8185-79f879144383
date added to LUP
2017-05-10 17:44:06
date last changed
2017-09-21 14:31:52
@article{08378271-48a7-4272-8185-79f879144383,
  abstract     = {<p>It has been suggested that calcium changes the set point of the pituitary thyroid feedback. It is not known, however, if small and slow changes of calcium and/or parathyroid hormone (PTH) within the physiological range influence the serum levels of thyrotropin (TSH) and thyroid hormones in healthy subjects or patients with primary hyperparathyroidism (pHPT). Nine healthy subjects and nine patients with pHPT were therefore investigated with an oral calcium load test. The patients were investigated before and 4 days after operation. During the test, serum levels of ionized calcium increased and serum levels of intact PTH decreased in both healthy subjects and patients pre- and postoperatively (p &lt; 0.001). Furthermore, in patients, the suppressibility of serum levels of PTH by calcium increased postoperatively (p &lt; 0.05). Serum levels of TSH decreased during the oral calcium load in healthy subjects (p &lt; 0.01) but not in patients, whereas the serum levels of thyroid hormones did not change. It is concluded that oral calcium influences TSH secretion in healthy humans but not in patients with pHPT.</p>},
  author       = {Bergenfelz, A and Ahrén, B},
  issn         = {0301-0163},
  keyword      = {Aged,Calcium,Case-Control Studies,Humans,Hyperparathyroidism,Middle Aged,Parathyroid Hormone,Pituitary Gland,Thyroid Hormones,Thyrotropin,Comparative Study,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  number       = {6},
  pages        = {7--273},
  publisher    = {Karger},
  series       = {Hormone Research},
  title        = {Serum levels of thyrotropin are decreased by oral calcium in healthy subjects but not in patients with primary hyperparathyroidism},
  url          = {http://dx.doi.org/10.1159/000184208},
  volume       = {42},
  year         = {1994},
}