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Heparin does not seem to improve the function of pulmonary grafts for lung transplantation.

Lindstedt Ingemansson, Sandra LU ; Pierre, Leif LU ; Hlebowicz, Joanna LU and Ingemansson, Richard LU (2013) In Scandinavian Cardiovascular Journal1997-01-01+01:00 47(5). p.307-313
Abstract
Abstract Background. It has been debated whether or not heparin infusion before or after non-heart-beating donors are declared dead improves the quality of pulmonary grafts. In clinical lung transplantation with heart-beating donors (HBDs) heparin is routinely infused prior to organ harvesting since it is believed to improve pulmonary grafts by minimizing thrombosis formation in the pulmonary grafts. Here, we raise the question of whether or not the use of heparin in HBDs improves the quality of the pulmonary grafts. Methods. Twelve landrace pigs were divided into two groups of six animals; heparin was given prior to lung harvesting in one group, while the other group did not receive any heparin. The lungs were evaluated using an ex vivo... (More)
Abstract Background. It has been debated whether or not heparin infusion before or after non-heart-beating donors are declared dead improves the quality of pulmonary grafts. In clinical lung transplantation with heart-beating donors (HBDs) heparin is routinely infused prior to organ harvesting since it is believed to improve pulmonary grafts by minimizing thrombosis formation in the pulmonary grafts. Here, we raise the question of whether or not the use of heparin in HBDs improves the quality of the pulmonary grafts. Methods. Twelve landrace pigs were divided into two groups of six animals; heparin was given prior to lung harvesting in one group, while the other group did not receive any heparin. The lungs were evaluated using an ex vivo lung perfusion (EVLP) method. Results. No significant difference in arterial oxygen partial pressure (PaO2) was observed between the two groups at an inspired oxygen fraction (FiO2) of 1.0 (mean 69.2 kPa, range 46.1-77.0 in the non-heparin group, and 61.6 kPa, range 47.9-71.4 in the heparin group, p = 0.44), neither in pulmonary vascular resistance: mean 543 ((dyne × s)/cm(5)) (range 280-615) in the non-heparin group and 533 ((dyne × s)/cm(5)) (320-762) in the heparin group (p = 0.99). Conclusions. Heparin did not seem to improve pulmonary graft function in our animal model using conventional HBDs. (Less)
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Contribution to journal
publication status
published
subject
in
Scandinavian Cardiovascular Journal1997-01-01+01:00
volume
47
issue
5
pages
307 - 313
publisher
Taylor & Francis
external identifiers
  • wos:000324759300010
  • pmid:24050378
  • scopus:84884649247
ISSN
1651-2006
DOI
10.3109/14017431.2013.825734
language
English
LU publication?
yes
id
08722f49-642b-4161-91f5-f40c0416d562 (old id 4065611)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24050378?dopt=Abstract
date added to LUP
2013-10-03 20:18:27
date last changed
2019-05-26 03:14:48
@article{08722f49-642b-4161-91f5-f40c0416d562,
  abstract     = {Abstract Background. It has been debated whether or not heparin infusion before or after non-heart-beating donors are declared dead improves the quality of pulmonary grafts. In clinical lung transplantation with heart-beating donors (HBDs) heparin is routinely infused prior to organ harvesting since it is believed to improve pulmonary grafts by minimizing thrombosis formation in the pulmonary grafts. Here, we raise the question of whether or not the use of heparin in HBDs improves the quality of the pulmonary grafts. Methods. Twelve landrace pigs were divided into two groups of six animals; heparin was given prior to lung harvesting in one group, while the other group did not receive any heparin. The lungs were evaluated using an ex vivo lung perfusion (EVLP) method. Results. No significant difference in arterial oxygen partial pressure (PaO2) was observed between the two groups at an inspired oxygen fraction (FiO2) of 1.0 (mean 69.2 kPa, range 46.1-77.0 in the non-heparin group, and 61.6 kPa, range 47.9-71.4 in the heparin group, p = 0.44), neither in pulmonary vascular resistance: mean 543 ((dyne × s)/cm(5)) (range 280-615) in the non-heparin group and 533 ((dyne × s)/cm(5)) (320-762) in the heparin group (p = 0.99). Conclusions. Heparin did not seem to improve pulmonary graft function in our animal model using conventional HBDs.},
  author       = {Lindstedt Ingemansson, Sandra and Pierre, Leif and Hlebowicz, Joanna and Ingemansson, Richard},
  issn         = {1651-2006},
  language     = {eng},
  number       = {5},
  pages        = {307--313},
  publisher    = {Taylor & Francis},
  series       = {Scandinavian Cardiovascular Journal1997-01-01+01:00},
  title        = {Heparin does not seem to improve the function of pulmonary grafts for lung transplantation.},
  url          = {http://dx.doi.org/10.3109/14017431.2013.825734},
  volume       = {47},
  year         = {2013},
}