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Concordance of survival in family members with prostate cancer

Hemminki, Kari LU ; Ji, Jianguang LU ; Försti, Asta LU ; Sundquist, Jan LU and Lenner, Per (2008) In Journal of clinical oncology : official journal of the American Society of Clinical Oncology 26(10). p.9-1705
Abstract

PURPOSE: Several earlier studies have assessed survival in prostate cancer based on familial risk of this disease. As a novel concept, we posit that factors governing survival in prostate cancer are likely to be different from those governing risk of prostate cancer. To prove this, we searched for familial clustering of survival (ie, concordance of survival among family members).

PATIENTS AND METHODS: We used the nationwide Swedish Family-Cancer Database to estimate hazard rates (HRs) for cause-specific and overall survival in invasive prostate cancer. HRs show the probability of death in the study group compared with the reference group. The study covered 610 sons of affected fathers with median follow-up times for survival... (More)

PURPOSE: Several earlier studies have assessed survival in prostate cancer based on familial risk of this disease. As a novel concept, we posit that factors governing survival in prostate cancer are likely to be different from those governing risk of prostate cancer. To prove this, we searched for familial clustering of survival (ie, concordance of survival among family members).

PATIENTS AND METHODS: We used the nationwide Swedish Family-Cancer Database to estimate hazard rates (HRs) for cause-specific and overall survival in invasive prostate cancer. HRs show the probability of death in the study group compared with the reference group. The study covered 610 sons of affected fathers with median follow-up times for survival ranging from 34 to 76 months.

RESULTS: When the survival in sons was analyzed according to the fathers' length of survival, there was a concordance of prognosis; the HR was 0.62 for sons whose fathers had survived longer than 59 months, compared with sons whose fathers had survived fewer than 24 months (P for trend, .02). On a continuous scale, the sons' survival increased almost linearly with the fathers' survival time. When the analysis was reversed and HRs were derived for fathers, the concordance of good and poor survival remained.

CONCLUSION: The results are consistent in showing that both good and poor survival in prostate cancer aggregate in families. Genetic factors are likely to contribute to the results, which provide the first challenging population-level evidence on heritability in prognosis of prostate cancer.

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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Disease-Free Survival, Fathers, Humans, Male, Nuclear Family, Pedigree, Prognosis, Prostatic Neoplasms/genetics, Registries, Survival Analysis, Survival Rate
in
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
volume
26
issue
10
pages
5 pages
publisher
American Society of Clinical Oncology
ISSN
1527-7755
DOI
10.1200/JCO.2007.13.3355
language
English
LU publication?
no
id
0879da3b-9cdb-4cce-a2f2-769d774311ed
date added to LUP
2019-01-30 10:52:25
date last changed
2019-03-08 02:16:44
@article{0879da3b-9cdb-4cce-a2f2-769d774311ed,
  abstract     = {<p>PURPOSE: Several earlier studies have assessed survival in prostate cancer based on familial risk of this disease. As a novel concept, we posit that factors governing survival in prostate cancer are likely to be different from those governing risk of prostate cancer. To prove this, we searched for familial clustering of survival (ie, concordance of survival among family members).</p><p>PATIENTS AND METHODS: We used the nationwide Swedish Family-Cancer Database to estimate hazard rates (HRs) for cause-specific and overall survival in invasive prostate cancer. HRs show the probability of death in the study group compared with the reference group. The study covered 610 sons of affected fathers with median follow-up times for survival ranging from 34 to 76 months.</p><p>RESULTS: When the survival in sons was analyzed according to the fathers' length of survival, there was a concordance of prognosis; the HR was 0.62 for sons whose fathers had survived longer than 59 months, compared with sons whose fathers had survived fewer than 24 months (P for trend, .02). On a continuous scale, the sons' survival increased almost linearly with the fathers' survival time. When the analysis was reversed and HRs were derived for fathers, the concordance of good and poor survival remained.</p><p>CONCLUSION: The results are consistent in showing that both good and poor survival in prostate cancer aggregate in families. Genetic factors are likely to contribute to the results, which provide the first challenging population-level evidence on heritability in prognosis of prostate cancer.</p>},
  author       = {Hemminki, Kari and Ji, Jianguang and Försti, Asta and Sundquist, Jan and Lenner, Per},
  issn         = {1527-7755},
  keyword      = {Disease-Free Survival,Fathers,Humans,Male,Nuclear Family,Pedigree,Prognosis,Prostatic Neoplasms/genetics,Registries,Survival Analysis,Survival Rate},
  language     = {eng},
  month        = {04},
  number       = {10},
  pages        = {9--1705},
  publisher    = {American Society of Clinical Oncology},
  series       = {Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  title        = {Concordance of survival in family members with prostate cancer},
  url          = {http://dx.doi.org/10.1200/JCO.2007.13.3355},
  volume       = {26},
  year         = {2008},
}