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Tumour biology of a breast cancer at least partly reflects the biology of the tissue/epithelial cell of origin at the time of initiation - a hypothesis

Olsson, Håkan LU orcid (2000) In Journal of Steroid Biochemistry and Molecular Biology 74(5). p.345-350
Abstract

A hypothesis is presented suggesting that initiation of breast epithelial cell freezes the cell at least partly according to the development/differention of cell at the time of initiation. Tumour biology will mimic the physiology of normal cell development at the time of initiation and this is preserved at least partly onwards. Also preferentially, tumours will develop from the cell type that is proliferating at the time of initiation. This may explain the overrepresentation of different types of histology in breast cancer in relation to age of the woman. The development of each tumour may follow at least partly a distinct pathway of evolution.

Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Age Factors, Age of Onset, BRCA2 Protein, Breast, Breast Neoplasms, Cell Differentiation, Epithelial Cells, Female, Genes, BRCA1, Genetic Predisposition to Disease, Humans, Models, Biological, Neoplasm Proteins, Prognosis, Risk Factors, Transcription Factors
in
Journal of Steroid Biochemistry and Molecular Biology
volume
74
issue
5
pages
345 - 350
publisher
Elsevier
external identifiers
  • pmid:11162943
  • scopus:0034735866
ISSN
0960-0760
language
English
LU publication?
yes
id
087e173d-5faf-4b53-b0f8-954cdac55cde
date added to LUP
2016-09-18 12:26:21
date last changed
2025-01-12 11:23:52
@article{087e173d-5faf-4b53-b0f8-954cdac55cde,
  abstract     = {{<p>A hypothesis is presented suggesting that initiation of breast epithelial cell freezes the cell at least partly according to the development/differention of cell at the time of initiation. Tumour biology will mimic the physiology of normal cell development at the time of initiation and this is preserved at least partly onwards. Also preferentially, tumours will develop from the cell type that is proliferating at the time of initiation. This may explain the overrepresentation of different types of histology in breast cancer in relation to age of the woman. The development of each tumour may follow at least partly a distinct pathway of evolution.</p>}},
  author       = {{Olsson, Håkan}},
  issn         = {{0960-0760}},
  keywords     = {{Age Factors; Age of Onset; BRCA2 Protein; Breast; Breast Neoplasms; Cell Differentiation; Epithelial Cells; Female; Genes, BRCA1; Genetic Predisposition to Disease; Humans; Models, Biological; Neoplasm Proteins; Prognosis; Risk Factors; Transcription Factors}},
  language     = {{eng}},
  month        = {{11}},
  number       = {{5}},
  pages        = {{345--350}},
  publisher    = {{Elsevier}},
  series       = {{Journal of Steroid Biochemistry and Molecular Biology}},
  title        = {{Tumour biology of a breast cancer at least partly reflects the biology of the tissue/epithelial cell of origin at the time of initiation - a hypothesis}},
  volume       = {{74}},
  year         = {{2000}},
}