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Risk of familial breast cancer is not increased after pregnancy

Hemminki, Kari LU ; Försti, Asta LU ; Sundquist, Jan LU and Ji, Jianguang LU (2008) In Breast Cancer Research and Treatment 108(3). p.417-420
Abstract

Risk of breast cancer is temporarily elevated shortly after pregnancy and the available limited data suggest that a family history of breast cancer may reinforce the risk. We used the nation-wide Swedish Family-Cancer Database to estimate the relative risk (RR) for invasive breast cancer following childbirth among women with or without a family history. The RRs were defined using Poisson regression model of person-years as offset, adjusted for age, period and age at first childbirth. For women without a family history, RRs for breast cancer showed a U-shaped pattern after last pregnancy. Among the 5,217 patients with a first-degree family history the familial risk was 1.77; there was no evidence of increased RRs immediately after last... (More)

Risk of breast cancer is temporarily elevated shortly after pregnancy and the available limited data suggest that a family history of breast cancer may reinforce the risk. We used the nation-wide Swedish Family-Cancer Database to estimate the relative risk (RR) for invasive breast cancer following childbirth among women with or without a family history. The RRs were defined using Poisson regression model of person-years as offset, adjusted for age, period and age at first childbirth. For women without a family history, RRs for breast cancer showed a U-shaped pattern after last pregnancy. Among the 5,217 patients with a first-degree family history the familial risk was 1.77; there was no evidence of increased RRs immediately after last pregnancy. The present study is by far the largest one published on the theme. It shows that pregnancy is not an additional risk factor for women with a family history.

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author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Familial breast cancer, Heredity, Parity, Pregnancy
in
Breast Cancer Research and Treatment
volume
108
issue
3
pages
4 pages
publisher
Springer
external identifiers
  • scopus:41149123201
ISSN
0167-6806
DOI
10.1007/s10549-007-9611-y
language
English
LU publication?
no
id
08cda4a1-b060-4c20-9bcf-a4a7b66bc34b
date added to LUP
2019-01-30 10:40:23
date last changed
2019-03-08 02:17:01
@article{08cda4a1-b060-4c20-9bcf-a4a7b66bc34b,
  abstract     = {<p>Risk of breast cancer is temporarily elevated shortly after pregnancy and the available limited data suggest that a family history of breast cancer may reinforce the risk. We used the nation-wide Swedish Family-Cancer Database to estimate the relative risk (RR) for invasive breast cancer following childbirth among women with or without a family history. The RRs were defined using Poisson regression model of person-years as offset, adjusted for age, period and age at first childbirth. For women without a family history, RRs for breast cancer showed a U-shaped pattern after last pregnancy. Among the 5,217 patients with a first-degree family history the familial risk was 1.77; there was no evidence of increased RRs immediately after last pregnancy. The present study is by far the largest one published on the theme. It shows that pregnancy is not an additional risk factor for women with a family history.</p>},
  author       = {Hemminki, Kari and Försti, Asta and Sundquist, Jan and Ji, Jianguang},
  issn         = {0167-6806},
  keyword      = {Familial breast cancer,Heredity,Parity,Pregnancy},
  language     = {eng},
  month        = {04},
  number       = {3},
  pages        = {417--420},
  publisher    = {Springer},
  series       = {Breast Cancer Research and Treatment},
  title        = {Risk of familial breast cancer is not increased after pregnancy},
  url          = {http://dx.doi.org/10.1007/s10549-007-9611-y},
  volume       = {108},
  year         = {2008},
}