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Associations Between Endometriosis and Gut Microbiota

Svensson, Agnes LU orcid ; Brunkwall, Louise LU ; Roth, Bodil LU ; Orho-Melander, Marju LU and Ohlsson, Bodil LU (2021) In Reproductive Sciences 28(8). p.2367-2377
Abstract

The gut microbiota has been associated with many diseases, including endometriosis. However, very few studies have been conducted on this topic in human. This study aimed to investigate the association between endometriosis and gut microbiota. Women with endometriosis (N=66) were identified at the Department of Gynaecology and each patient was matched with three controls (N=198) from the general population. All participants answered questionnaires about socioeconomic data, medical history, and gastrointestinal symptoms and passed stool samples. Gut bacteria were analyzed using 16S ribosomal RNA sequencing, and in total, 58 bacteria were observed at genus level in both patients with endometriosis and controls. Comparisons of the... (More)

The gut microbiota has been associated with many diseases, including endometriosis. However, very few studies have been conducted on this topic in human. This study aimed to investigate the association between endometriosis and gut microbiota. Women with endometriosis (N=66) were identified at the Department of Gynaecology and each patient was matched with three controls (N=198) from the general population. All participants answered questionnaires about socioeconomic data, medical history, and gastrointestinal symptoms and passed stool samples. Gut bacteria were analyzed using 16S ribosomal RNA sequencing, and in total, 58 bacteria were observed at genus level in both patients with endometriosis and controls. Comparisons of the microbiota between patients and controls and within the endometriosis cohort were performed. Both alpha and beta diversities were higher in controls than in patients. With the false discovery rate q<0.05, abundance of 12 bacteria belonging to the classes Bacilli, Bacteroidia, Clostridia, Coriobacteriia, and Gammaproteobacter differed significantly between patients and controls. Differences observed between patients with or without isolated ovarian endometriosis, involvement of the gastrointestinal tract, gastrointestinal symptoms, or hormonal treatment disappeared after calculation with false discovery rate. These findings indicate that the gut microbiota may be altered in endometriosis patients.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Reproductive Sciences
volume
28
issue
8
pages
2367 - 2377
publisher
SAGE Publications
external identifiers
  • pmid:33660232
  • scopus:85102036922
ISSN
1933-7191
DOI
10.1007/s43032-021-00506-5
project
Endometriosis and gastrointestinal symptoms
language
English
LU publication?
yes
id
0a103b1c-0bc6-4502-bfd6-0b98fcd00a3a
date added to LUP
2021-03-10 12:58:00
date last changed
2024-06-13 08:33:17
@article{0a103b1c-0bc6-4502-bfd6-0b98fcd00a3a,
  abstract     = {{<p>The gut microbiota has been associated with many diseases, including endometriosis. However, very few studies have been conducted on this topic in human. This study aimed to investigate the association between endometriosis and gut microbiota. Women with endometriosis (N=66) were identified at the Department of Gynaecology and each patient was matched with three controls (N=198) from the general population. All participants answered questionnaires about socioeconomic data, medical history, and gastrointestinal symptoms and passed stool samples. Gut bacteria were analyzed using 16S ribosomal RNA sequencing, and in total, 58 bacteria were observed at genus level in both patients with endometriosis and controls. Comparisons of the microbiota between patients and controls and within the endometriosis cohort were performed. Both alpha and beta diversities were higher in controls than in patients. With the false discovery rate q&lt;0.05, abundance of 12 bacteria belonging to the classes Bacilli, Bacteroidia, Clostridia, Coriobacteriia, and Gammaproteobacter differed significantly between patients and controls. Differences observed between patients with or without isolated ovarian endometriosis, involvement of the gastrointestinal tract, gastrointestinal symptoms, or hormonal treatment disappeared after calculation with false discovery rate. These findings indicate that the gut microbiota may be altered in endometriosis patients.</p>}},
  author       = {{Svensson, Agnes and Brunkwall, Louise and Roth, Bodil and Orho-Melander, Marju and Ohlsson, Bodil}},
  issn         = {{1933-7191}},
  language     = {{eng}},
  month        = {{03}},
  number       = {{8}},
  pages        = {{2367--2377}},
  publisher    = {{SAGE Publications}},
  series       = {{Reproductive Sciences}},
  title        = {{Associations Between Endometriosis and Gut Microbiota}},
  url          = {{http://dx.doi.org/10.1007/s43032-021-00506-5}},
  doi          = {{10.1007/s43032-021-00506-5}},
  volume       = {{28}},
  year         = {{2021}},
}