Neuronal activity dynamics in the dentate gyrus during early epileptogenesis
Berglind, Fredrik LU ; Boulot, Adrien LU ; Gonzalez-Ramos, Ana LU ; Melin, Esbjörn LU
; Bono, Antonino
; Sørensen, Andreas Toft
and Ledri, Marco
LU
(2023)
In Epilepsy Research
194.
- Abstract
Epileptogenesis is a complex process involving a multitude of changes at the molecular, cellular and network level. Previous studies have identified several key alterations contributing to epileptogenesis and the development of hyper-excitability in different animal models, but only a few have focused on the early stages of this process. For post status epilepticus (SE) temporal lobe epilepsy in particular, understanding network dynamics during the early phases might be crucial for developing accurate preventive treatments to block the development of chronic spontaneous seizures. In this study, we used a viral vector mediated approach to examine activity of neurons in the dentate gyrus of the hippocampus during early epileptogenesis. We... (More)
Epileptogenesis is a complex process involving a multitude of changes at the molecular, cellular and network level. Previous studies have identified several key alterations contributing to epileptogenesis and the development of hyper-excitability in different animal models, but only a few have focused on the early stages of this process. For post status epilepticus (SE) temporal lobe epilepsy in particular, understanding network dynamics during the early phases might be crucial for developing accurate preventive treatments to block the development of chronic spontaneous seizures. In this study, we used a viral vector mediated approach to examine activity of neurons in the dentate gyrus of the hippocampus during early epileptogenesis. We find that while granule cells are active 8 h after SE and then gradually decrease their activity, Calretinin-positive mossy cells and Neuropeptide Y-positive GABAergic interneurons in the hilus show a delayed activation pattern starting at 24 and peaking at 48 h after SE. These data suggest that indirect inhibition of granule cells by mossy cells through recruitment of local GABAergic interneurons could be an important mechanisms of excitability control during early epileptogenesis, and contribute to our understanding of the complex role of these cells in normal and pathological conditions.
(Less)
- author
- Berglind, Fredrik
LU
; Boulot, Adrien
LU
; Gonzalez-Ramos, Ana
LU
; Melin, Esbjörn
LU
; Bono, Antonino
; Sørensen, Andreas Toft
and Ledri, Marco
LU
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Calretinin, Epileptogenesis, Kainic Acid, Mossy Cells, RAM
- in
- Epilepsy Research
- volume
- 194
- article number
- 107182
- publisher
- Elsevier
- external identifiers
-
- pmid:37364343
- scopus:85162889215
- ISSN
- 0920-1211
- DOI
- 10.1016/j.eplepsyres.2023.107182
- language
- English
- LU publication?
- yes
- id
- 0ae427a9-95ef-47b5-aaec-78ad98422072
- date added to LUP
- 2023-09-12 11:48:53
- date last changed
- 2024-04-20 03:07:06
@article{0ae427a9-95ef-47b5-aaec-78ad98422072,
abstract = {{<p>Epileptogenesis is a complex process involving a multitude of changes at the molecular, cellular and network level. Previous studies have identified several key alterations contributing to epileptogenesis and the development of hyper-excitability in different animal models, but only a few have focused on the early stages of this process. For post status epilepticus (SE) temporal lobe epilepsy in particular, understanding network dynamics during the early phases might be crucial for developing accurate preventive treatments to block the development of chronic spontaneous seizures. In this study, we used a viral vector mediated approach to examine activity of neurons in the dentate gyrus of the hippocampus during early epileptogenesis. We find that while granule cells are active 8 h after SE and then gradually decrease their activity, Calretinin-positive mossy cells and Neuropeptide Y-positive GABAergic interneurons in the hilus show a delayed activation pattern starting at 24 and peaking at 48 h after SE. These data suggest that indirect inhibition of granule cells by mossy cells through recruitment of local GABAergic interneurons could be an important mechanisms of excitability control during early epileptogenesis, and contribute to our understanding of the complex role of these cells in normal and pathological conditions.</p>}},
author = {{Berglind, Fredrik and Boulot, Adrien and Gonzalez-Ramos, Ana and Melin, Esbjörn and Bono, Antonino and Sørensen, Andreas Toft and Ledri, Marco}},
issn = {{0920-1211}},
keywords = {{Calretinin; Epileptogenesis; Kainic Acid; Mossy Cells; RAM}},
language = {{eng}},
publisher = {{Elsevier}},
series = {{Epilepsy Research}},
title = {{Neuronal activity dynamics in the dentate gyrus during early epileptogenesis}},
url = {{http://dx.doi.org/10.1016/j.eplepsyres.2023.107182}},
doi = {{10.1016/j.eplepsyres.2023.107182}},
volume = {{194}},
year = {{2023}},
}