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Inflammatory cells and mediators in the silicone chamber model for nerve regeneration

Danielsen, Nils LU ; Dahlin, L B LU and Thomsen, P. (1993) In Biomaterials 14(15). p.5-1180
Abstract

In the present study the inflammatory response was quantitatively evaluated during peripheral nerve regeneration. The fluid from silicone nerve regeneration chambers, inserted in rats, was collected during the early period of regeneration of transected sciatic nerves (6 h-7 d) and analysed with respect to inflammatory cells and mediators (leukotriene B4, LTB4, and interleukin-1 alpha, IL-1 alpha). Leucocytes were detected during the entire period (up to 7 d after implantation). The highest concentration was detected after 24 h. PMNG (polymorphonuclear granulocyte) was the predominant cell type in the chamber fluid during the initial 5d of regeneration. Analysis of the concentration of LTB4 demonstrated two peaks (at 24 h and 5 d). The... (More)

In the present study the inflammatory response was quantitatively evaluated during peripheral nerve regeneration. The fluid from silicone nerve regeneration chambers, inserted in rats, was collected during the early period of regeneration of transected sciatic nerves (6 h-7 d) and analysed with respect to inflammatory cells and mediators (leukotriene B4, LTB4, and interleukin-1 alpha, IL-1 alpha). Leucocytes were detected during the entire period (up to 7 d after implantation). The highest concentration was detected after 24 h. PMNG (polymorphonuclear granulocyte) was the predominant cell type in the chamber fluid during the initial 5d of regeneration. Analysis of the concentration of LTB4 demonstrated two peaks (at 24 h and 5 d). The IL-1 alpha concentration displayed an early and relatively smaller peak after 24 h and a second and much larger peak after 7 d, concomitant with an increase of the number of mononuclear cells.

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Contribution to journal
publication status
published
subject
keywords
Animals, Biocompatible Materials, Female, Inflammation, Interleukin-1, Leukotriene B4, Materials Testing, Models, Neurological, Nerve Regeneration, Rats, Rats, Sprague-Dawley, Sciatic Nerve, Silicones, Journal Article, Research Support, Non-U.S. Gov't
in
Biomaterials
volume
14
issue
15
pages
5 - 1180
publisher
Elsevier
external identifiers
  • scopus:0027772309
ISSN
0142-9612
DOI
10.1016/0142-9612(93)90164-W
language
English
LU publication?
yes
id
0af945bb-b51b-43e7-ab4d-afd960034cc9
date added to LUP
2017-10-13 13:51:56
date last changed
2017-11-06 10:51:17
@article{0af945bb-b51b-43e7-ab4d-afd960034cc9,
  abstract     = {<p>In the present study the inflammatory response was quantitatively evaluated during peripheral nerve regeneration. The fluid from silicone nerve regeneration chambers, inserted in rats, was collected during the early period of regeneration of transected sciatic nerves (6 h-7 d) and analysed with respect to inflammatory cells and mediators (leukotriene B4, LTB4, and interleukin-1 alpha, IL-1 alpha). Leucocytes were detected during the entire period (up to 7 d after implantation). The highest concentration was detected after 24 h. PMNG (polymorphonuclear granulocyte) was the predominant cell type in the chamber fluid during the initial 5d of regeneration. Analysis of the concentration of LTB4 demonstrated two peaks (at 24 h and 5 d). The IL-1 alpha concentration displayed an early and relatively smaller peak after 24 h and a second and much larger peak after 7 d, concomitant with an increase of the number of mononuclear cells.</p>},
  author       = {Danielsen, Nils and Dahlin, L B and Thomsen, P.},
  issn         = {0142-9612},
  keyword      = {Animals,Biocompatible Materials,Female,Inflammation,Interleukin-1,Leukotriene B4,Materials Testing,Models, Neurological,Nerve Regeneration,Rats,Rats, Sprague-Dawley,Sciatic Nerve,Silicones,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  number       = {15},
  pages        = {5--1180},
  publisher    = {Elsevier},
  series       = {Biomaterials},
  title        = {Inflammatory cells and mediators in the silicone chamber model for nerve regeneration},
  url          = {http://dx.doi.org/10.1016/0142-9612(93)90164-W},
  volume       = {14},
  year         = {1993},
}