The effect of prostate motion during hypofractionated radiotherapy can be reduced by using flattening filter free beams
Benedek, Hunor LU ; Lerner, Minna LU ; Nilsson, Per LU
; Knoos, Tommy
LU
; Gunnlaugsson, Adalsteinn
LU
and Ceberg, Crister
LU
(2018)
In Physics and imaging in radiation oncology
6.
p.66-70
- Abstract
- Background and purpose: Hypofractionated radiotherapy of prostate cancer reduces the overall treatment time but increases the per-fraction beam-on time due to the higher fraction doses. This increased fraction treatment time results in a larger uncertainty of the prostate position. The purpose of this study was to investigate the effect of prostate motion during flattening filter free (FFF) Volumetric Modulated Arc Therapy (VMAT) in ultrahypofractionation of prostate cancer radiotherapy with preserved plan quality compared to conventional flattened beams.
Materials and methods: Nine prostate patients from the Scandinavian HYPO-RT-PC trial were re-planned using VMAT technique with both conventional and flattening filter free beams. Two... (More) - Background and purpose: Hypofractionated radiotherapy of prostate cancer reduces the overall treatment time but increases the per-fraction beam-on time due to the higher fraction doses. This increased fraction treatment time results in a larger uncertainty of the prostate position. The purpose of this study was to investigate the effect of prostate motion during flattening filter free (FFF) Volumetric Modulated Arc Therapy (VMAT) in ultrahypofractionation of prostate cancer radiotherapy with preserved plan quality compared to conventional flattened beams.
Materials and methods: Nine prostate patients from the Scandinavian HYPO-RT-PC trial were re-planned using VMAT technique with both conventional and flattening filter free beams. Two fractionation schedules were used, one hypofractionated (42.7 Gy in 7 fractions), and one conventional (78.0 Gy in 39 fractions). Pre-treatment verification measurements were performed on all plans and the treatment time was recorded. Measurements with simulated prostate motion were performed for the plans with the longest treatment times. Results: All the 10FFF plans fulfilled the clinical gamma pass rate, 90% (3%, 2 mm), during all simulated prostate motion trajectories. The 10MV plans only fulfilled the clinical pass rate for three of the trajectories. The mean beam-on-time for the hypofractionated plans were reduced from 2.3 min to 1.0 min when using 10FFF compared to 10MV. No clinically relevant differences in dose distribution were identified when comparing the plans with different beam qualities. Conclusion: Flattening-filter free VMAT reduces treatment times, limiting the dosimetric effect of organ motion for ultrahypofractionated prostate cancer with preserved plan quality. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/0c9fe425-bd63-4d72-a3c1-beead0cce9aa
- author
- Benedek, Hunor
LU
; Lerner, Minna
LU
; Nilsson, Per
LU
; Knoos, Tommy
LU
; Gunnlaugsson, Adalsteinn
LU
and Ceberg, Crister
LU
- organization
- publishing date
- 2018-04
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Physics and imaging in radiation oncology
- volume
- 6
- pages
- 5 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:85068160256
- ISSN
- 2405-6316
- DOI
- 10.1016/j.phro.2018.05.001
- language
- English
- LU publication?
- yes
- id
- 0c9fe425-bd63-4d72-a3c1-beead0cce9aa
- date added to LUP
- 2019-06-18 10:14:30
- date last changed
- 2022-03-18 01:55:40
@article{0c9fe425-bd63-4d72-a3c1-beead0cce9aa,
abstract = {{Background and purpose: Hypofractionated radiotherapy of prostate cancer reduces the overall treatment time but increases the per-fraction beam-on time due to the higher fraction doses. This increased fraction treatment time results in a larger uncertainty of the prostate position. The purpose of this study was to investigate the effect of prostate motion during flattening filter free (FFF) Volumetric Modulated Arc Therapy (VMAT) in ultrahypofractionation of prostate cancer radiotherapy with preserved plan quality compared to conventional flattened beams.<br/>Materials and methods: Nine prostate patients from the Scandinavian HYPO-RT-PC trial were re-planned using VMAT technique with both conventional and flattening filter free beams. Two fractionation schedules were used, one hypofractionated (42.7 Gy in 7 fractions), and one conventional (78.0 Gy in 39 fractions). Pre-treatment verification measurements were performed on all plans and the treatment time was recorded. Measurements with simulated prostate motion were performed for the plans with the longest treatment times. Results: All the 10FFF plans fulfilled the clinical gamma pass rate, 90% (3%, 2 mm), during all simulated prostate motion trajectories. The 10MV plans only fulfilled the clinical pass rate for three of the trajectories. The mean beam-on-time for the hypofractionated plans were reduced from 2.3 min to 1.0 min when using 10FFF compared to 10MV. No clinically relevant differences in dose distribution were identified when comparing the plans with different beam qualities. Conclusion: Flattening-filter free VMAT reduces treatment times, limiting the dosimetric effect of organ motion for ultrahypofractionated prostate cancer with preserved plan quality.}},
author = {{Benedek, Hunor and Lerner, Minna and Nilsson, Per and Knoos, Tommy and Gunnlaugsson, Adalsteinn and Ceberg, Crister}},
issn = {{2405-6316}},
language = {{eng}},
pages = {{66--70}},
publisher = {{Elsevier}},
series = {{Physics and imaging in radiation oncology}},
title = {{The effect of prostate motion during hypofractionated radiotherapy can be reduced by using flattening filter free beams}},
url = {{http://dx.doi.org/10.1016/j.phro.2018.05.001}},
doi = {{10.1016/j.phro.2018.05.001}},
volume = {{6}},
year = {{2018}},
}