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The dasyscyphins A similar to C and niveulone, new biologically active compounds from the ascomycete Dasyscyphus niveus

Mierau, V ; de la Parra, Veronica LU ; Sterner, Olov LU and Anke, T (2006) In Journal of Antibiotics 59(1). p.53-56
Abstract
In the course of a screening for cytotoxic Compounds from fungi four new terpenoid metabolites, named dasyscyphins A, B, C, and niveulone were isolated from fermentations of Dasyscyphus niveus strain A0101. While dasyscyphin A (1) exhibited no significant biological activities in our test systems dasyscyphin B (2) and dasyscyphin C (3) showed cytotoxic activities against human (HepG2, Hela S3, U937, Colo-320, Jurkat) cell lines with IC50-values of 0.5 similar to 3 mu g/ml while the activity of niveulone (4) was less pronounced. Only modest or weak antibiotic properties were observed for (2) and (3).
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
activities, cytotoxic, Dasyscyphus niveus, niveulone, dasyscyphins, A similar to C
in
Journal of Antibiotics
volume
59
issue
1
pages
53 - 56
publisher
Japan Antibiotics Research Association
external identifiers
  • pmid:16568719
  • wos:000235298300008
  • scopus:33644555234
ISSN
0021-8820
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)
id
0cc4822f-2c4a-4056-996c-4e1b5085d51d (old id 417817)
alternative location
http://www.jstage.jst.go.jp/article/antibiotics/59/1/59_53/_article
date added to LUP
2016-04-01 15:33:38
date last changed
2020-01-12 18:34:25
@article{0cc4822f-2c4a-4056-996c-4e1b5085d51d,
  abstract     = {In the course of a screening for cytotoxic Compounds from fungi four new terpenoid metabolites, named dasyscyphins A, B, C, and niveulone were isolated from fermentations of Dasyscyphus niveus strain A0101. While dasyscyphin A (1) exhibited no significant biological activities in our test systems dasyscyphin B (2) and dasyscyphin C (3) showed cytotoxic activities against human (HepG2, Hela S3, U937, Colo-320, Jurkat) cell lines with IC50-values of 0.5 similar to 3 mu g/ml while the activity of niveulone (4) was less pronounced. Only modest or weak antibiotic properties were observed for (2) and (3).},
  author       = {Mierau, V and de la Parra, Veronica and Sterner, Olov and Anke, T},
  issn         = {0021-8820},
  language     = {eng},
  number       = {1},
  pages        = {53--56},
  publisher    = {Japan Antibiotics Research Association},
  series       = {Journal of Antibiotics},
  title        = {The dasyscyphins A similar to C and niveulone, new biologically active compounds from the ascomycete Dasyscyphus niveus},
  url          = {http://www.jstage.jst.go.jp/article/antibiotics/59/1/59_53/_article},
  volume       = {59},
  year         = {2006},
}