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ECG Markers of Acute Melatonin Treatment in a Porcine Model of Acute Myocardial Ischemia

Bernikova, Olesya G. ; Tsvetkova, Alena S. ; Ovechkin, Alexey O. ; Demidova, Marina M. LU ; Azarov, Jan E. and Platonov, Pyotr G. LU (2022) In International Journal of Molecular Sciences 23(19).
Abstract

In myocardial ischemia, melatonin confers antiarrhythmic action, but its electrocardiographic expression is unclear. We aimed to evaluate the effects of melatonin treatment on electrocardiogram (ECG) parameters reflecting major arrhythmogenic factors and to test the association of these parameters with ventricular fibrillation (VF) incidence. Myocardial ischemia was induced by 40 min coronary artery occlusion in 25 anesthetized pigs. After induction of ischemia, 12 and 13 animals were given melatonin or placebo, respectively. Twelve-lead ECGs were recorded and durations of QRS, QT, Tpeak-Tend intervals and extrasystolic burden were measured at baseline and during occlusion. During ischemia, VF episodes clustered into early and delayed... (More)

In myocardial ischemia, melatonin confers antiarrhythmic action, but its electrocardiographic expression is unclear. We aimed to evaluate the effects of melatonin treatment on electrocardiogram (ECG) parameters reflecting major arrhythmogenic factors and to test the association of these parameters with ventricular fibrillation (VF) incidence. Myocardial ischemia was induced by 40 min coronary artery occlusion in 25 anesthetized pigs. After induction of ischemia, 12 and 13 animals were given melatonin or placebo, respectively. Twelve-lead ECGs were recorded and durations of QRS, QT, Tpeak-Tend intervals and extrasystolic burden were measured at baseline and during occlusion. During ischemia, VF episodes clustered into early and delayed phases (<10 and >20 min, respectively), and QRS duration was associated with VF incidence. QT interval and extrasystolic burden did not differ between the groups. The Tpeak-Tend interval was progressively prolonged, and the prolongation was less pronounced in the treated animals. QRS duration increased, demonstrating two maxima (5–10 and 25 min, respectively). In the melatonin group, the earlier maximum was blunted, and VF development in this period was prevented. Thus, acute melatonin treatment prevented excessive prolongation of the QRS and Tpeak-Tend intervals in the porcine myocardial infarction model, and QRS duration can be used for the assessment of antiarrhythmic action of melatonin.

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; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
electrocardiogram, extrasystolic burden, melatonin, myocardial ischemia, ventricular fibrillation
in
International Journal of Molecular Sciences
volume
23
issue
19
article number
11800
publisher
MDPI AG
external identifiers
  • scopus:85139968593
  • pmid:36233101
ISSN
1661-6596
DOI
10.3390/ijms231911800
language
English
LU publication?
yes
id
0dd09101-c041-4078-b441-03ee2752edf5
date added to LUP
2022-12-14 13:48:16
date last changed
2024-11-25 10:00:01
@article{0dd09101-c041-4078-b441-03ee2752edf5,
  abstract     = {{<p>In myocardial ischemia, melatonin confers antiarrhythmic action, but its electrocardiographic expression is unclear. We aimed to evaluate the effects of melatonin treatment on electrocardiogram (ECG) parameters reflecting major arrhythmogenic factors and to test the association of these parameters with ventricular fibrillation (VF) incidence. Myocardial ischemia was induced by 40 min coronary artery occlusion in 25 anesthetized pigs. After induction of ischemia, 12 and 13 animals were given melatonin or placebo, respectively. Twelve-lead ECGs were recorded and durations of QRS, QT, Tpeak-Tend intervals and extrasystolic burden were measured at baseline and during occlusion. During ischemia, VF episodes clustered into early and delayed phases (&lt;10 and &gt;20 min, respectively), and QRS duration was associated with VF incidence. QT interval and extrasystolic burden did not differ between the groups. The Tpeak-Tend interval was progressively prolonged, and the prolongation was less pronounced in the treated animals. QRS duration increased, demonstrating two maxima (5–10 and 25 min, respectively). In the melatonin group, the earlier maximum was blunted, and VF development in this period was prevented. Thus, acute melatonin treatment prevented excessive prolongation of the QRS and Tpeak-Tend intervals in the porcine myocardial infarction model, and QRS duration can be used for the assessment of antiarrhythmic action of melatonin.</p>}},
  author       = {{Bernikova, Olesya G. and Tsvetkova, Alena S. and Ovechkin, Alexey O. and Demidova, Marina M. and Azarov, Jan E. and Platonov, Pyotr G.}},
  issn         = {{1661-6596}},
  keywords     = {{electrocardiogram; extrasystolic burden; melatonin; myocardial ischemia; ventricular fibrillation}},
  language     = {{eng}},
  number       = {{19}},
  publisher    = {{MDPI AG}},
  series       = {{International Journal of Molecular Sciences}},
  title        = {{ECG Markers of Acute Melatonin Treatment in a Porcine Model of Acute Myocardial Ischemia}},
  url          = {{http://dx.doi.org/10.3390/ijms231911800}},
  doi          = {{10.3390/ijms231911800}},
  volume       = {{23}},
  year         = {{2022}},
}