Advanced

The Kärger vs bi-exponential model : Theoretical insights and experimental validations

Moutal, Nicolas; Nilsson, Markus LU ; Topgaard, Daniel LU and Grebenkov, Denis (2018) In Journal of Magnetic Resonance 296. p.72-78
Abstract

We revise three common models accounting for water exchange in pulsed-gradient spin-echo measurements: a bi-exponential model with time-dependent water fractions, the Kärger model, and a modified Kärger model designed for restricted diffusion, e.g. inside cells. The three models are compared and applied to experimental data from yeast cell suspensions. The Kärger model and the modified Kärger model yield very close results and accurately fit the data. The bi-exponential model, although less rigorous, has a natural physical interpretation and suggests a new experimental modality to estimate the water exchange time.

Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Bi-exponential model, Kärger model, Permeability, PGSE, Water exchange, Yeast cells
in
Journal of Magnetic Resonance
volume
296
pages
7 pages
publisher
Elsevier
external identifiers
  • scopus:85053311723
ISSN
1090-7807
DOI
10.1016/j.jmr.2018.08.015
language
English
LU publication?
yes
id
0e5d952c-08dd-4018-8ff1-255213658e92
date added to LUP
2018-10-09 08:28:28
date last changed
2019-02-20 11:30:10
@article{0e5d952c-08dd-4018-8ff1-255213658e92,
  abstract     = {<p>We revise three common models accounting for water exchange in pulsed-gradient spin-echo measurements: a bi-exponential model with time-dependent water fractions, the Kärger model, and a modified Kärger model designed for restricted diffusion, e.g. inside cells. The three models are compared and applied to experimental data from yeast cell suspensions. The Kärger model and the modified Kärger model yield very close results and accurately fit the data. The bi-exponential model, although less rigorous, has a natural physical interpretation and suggests a new experimental modality to estimate the water exchange time.</p>},
  author       = {Moutal, Nicolas and Nilsson, Markus and Topgaard, Daniel and Grebenkov, Denis},
  issn         = {1090-7807},
  keyword      = {Bi-exponential model,Kärger model,Permeability,PGSE,Water exchange,Yeast cells},
  language     = {eng},
  pages        = {72--78},
  publisher    = {Elsevier},
  series       = {Journal of Magnetic Resonance},
  title        = {The Kärger vs bi-exponential model : Theoretical insights and experimental validations},
  url          = {http://dx.doi.org/10.1016/j.jmr.2018.08.015},
  volume       = {296},
  year         = {2018},
}