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Spatial transcriptomics of human placentas reveal distinct RNA patterns associated with morphology and preeclampsia

Bhalla, Nayanika ; Franzén, Lovisa ; Scheynius, Annika ; Papadogiannakis, Nikos ; Hansson, Stefan R. LU orcid ; Lager, Susanne and Ståhl, Patrik L. (2023) In Placenta 139. p.213-216
Abstract

Spatial transcriptomics (ST) maps RNA level patterns within a tissue. This technology has not been previously applied to human placental tissue. We demonstrate analysis of human placental samples with ST. Unsupervised clustering revealed that distinct RNA patterns were found corresponding to different morphological structures. Additionally, when focusing upon terminal villi and hemoglobin associated structures, RNA levels differed between placentas from full term healthy pregnancies and those complicated by preeclampsia. The results from this study can provide a benchmark for future ST studies in placenta.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Differential gene expression, Hemoglobin, Morphology, Oxidoreductase pathway, Placenta, Preeclampsia, Pregnancy complications, Spatial transcriptomics, Villi
in
Placenta
volume
139
pages
4 pages
publisher
W.B. Saunders
external identifiers
  • pmid:37481829
  • scopus:85165700790
ISSN
0143-4004
DOI
10.1016/j.placenta.2023.07.004
language
English
LU publication?
yes
id
0ec1f633-97ad-464e-9ec3-fd77d60fd851
date added to LUP
2023-11-02 14:59:02
date last changed
2024-11-01 23:23:26
@article{0ec1f633-97ad-464e-9ec3-fd77d60fd851,
  abstract     = {{<p>Spatial transcriptomics (ST) maps RNA level patterns within a tissue. This technology has not been previously applied to human placental tissue. We demonstrate analysis of human placental samples with ST. Unsupervised clustering revealed that distinct RNA patterns were found corresponding to different morphological structures. Additionally, when focusing upon terminal villi and hemoglobin associated structures, RNA levels differed between placentas from full term healthy pregnancies and those complicated by preeclampsia. The results from this study can provide a benchmark for future ST studies in placenta.</p>}},
  author       = {{Bhalla, Nayanika and Franzén, Lovisa and Scheynius, Annika and Papadogiannakis, Nikos and Hansson, Stefan R. and Lager, Susanne and Ståhl, Patrik L.}},
  issn         = {{0143-4004}},
  keywords     = {{Differential gene expression; Hemoglobin; Morphology; Oxidoreductase pathway; Placenta; Preeclampsia; Pregnancy complications; Spatial transcriptomics; Villi}},
  language     = {{eng}},
  pages        = {{213--216}},
  publisher    = {{W.B. Saunders}},
  series       = {{Placenta}},
  title        = {{Spatial transcriptomics of human placentas reveal distinct RNA patterns associated with morphology and preeclampsia}},
  url          = {{http://dx.doi.org/10.1016/j.placenta.2023.07.004}},
  doi          = {{10.1016/j.placenta.2023.07.004}},
  volume       = {{139}},
  year         = {{2023}},
}