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Pulmonary 5-HT 2B receptor expression in fibrotic interstitial lung diseases.

Löfdahl, Anna LU ; Nybom, Annika LU ; Wigén, Jenny LU ; Dellgren, Göran ; Brunnström, Hans LU orcid ; Wenglén, Christina LU and Westergren-Thorsson, Gunilla LU orcid (2023) In Acta Histochemica 125(3). p.1-8
Abstract

Pulmonary fibrosis is a severe condition in interstitial lung diseases (ILD) such as idiopathic pulmonary fibrosis (IPF) and systemic sclerosis-ILD, where the underlying mechanism is not well defined and with no curative treatments available. Serotonin (5-HT) signaling via the 5-HT
2B receptor has been recognized as a promising preclinical target for fibrosis. Despite this, the involvement of the 5-HT
2B receptor in fibrotic ILD is widely unexplored. This work highlights the spatial pulmonary distribution of the 5-HT
2B receptor in patients with IPF and systemic sclerosis-ILD. We show that the 5-HT
2B receptor is located in typical pathological structures e.g. honeycomb cysts and weakly in fibroblast foci. Together... (More)

Pulmonary fibrosis is a severe condition in interstitial lung diseases (ILD) such as idiopathic pulmonary fibrosis (IPF) and systemic sclerosis-ILD, where the underlying mechanism is not well defined and with no curative treatments available. Serotonin (5-HT) signaling via the 5-HT
2B receptor has been recognized as a promising preclinical target for fibrosis. Despite this, the involvement of the 5-HT
2B receptor in fibrotic ILD is widely unexplored. This work highlights the spatial pulmonary distribution of the 5-HT
2B receptor in patients with IPF and systemic sclerosis-ILD. We show that the 5-HT
2B receptor is located in typical pathological structures e.g. honeycomb cysts and weakly in fibroblast foci. Together with immunohistochemistry and immunofluorescence stainings of patient derived distal lung tissues, we identified cell targets for 5-HT
2B receptor interference in type II alveolar epithelial cells, endothelial cells and M2 macrophages. Our results emphasize the role of 5-HT
2B receptor as a target in lung fibrosis, warranting further consideration in targeting fibrotic ILDs.

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Please use this url to cite or link to this publication:
author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Histochemica
volume
125
issue
3
article number
152024
pages
1 - 8
publisher
Elsevier
external identifiers
  • scopus:85150441094
  • pmid:36958084
ISSN
0065-1281
DOI
10.1016/j.acthis.2023.152024
language
English
LU publication?
yes
additional info
Copyright © 2023. Published by Elsevier GmbH.
id
0f2f1de9-a962-4285-8451-467fea913b30
date added to LUP
2023-03-30 20:00:00
date last changed
2024-06-15 01:44:30
@article{0f2f1de9-a962-4285-8451-467fea913b30,
  abstract     = {{<p>Pulmonary fibrosis is a severe condition in interstitial lung diseases (ILD) such as idiopathic pulmonary fibrosis (IPF) and systemic sclerosis-ILD, where the underlying mechanism is not well defined and with no curative treatments available. Serotonin (5-HT) signaling via the 5-HT<br>
 2B receptor has been recognized as a promising preclinical target for fibrosis. Despite this, the involvement of the 5-HT<br>
 2B receptor in fibrotic ILD is widely unexplored. This work highlights the spatial pulmonary distribution of the 5-HT<br>
 2B receptor in patients with IPF and systemic sclerosis-ILD. We show that the 5-HT<br>
 2B receptor is located in typical pathological structures e.g. honeycomb cysts and weakly in fibroblast foci. Together with immunohistochemistry and immunofluorescence stainings of patient derived distal lung tissues, we identified cell targets for 5-HT<br>
 2B receptor interference in type II alveolar epithelial cells, endothelial cells and M2 macrophages. Our results emphasize the role of 5-HT<br>
 2B receptor as a target in lung fibrosis, warranting further consideration in targeting fibrotic ILDs.<br>
 </p>}},
  author       = {{Löfdahl, Anna and Nybom, Annika and Wigén, Jenny and Dellgren, Göran and Brunnström, Hans and Wenglén, Christina and Westergren-Thorsson, Gunilla}},
  issn         = {{0065-1281}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{1--8}},
  publisher    = {{Elsevier}},
  series       = {{Acta Histochemica}},
  title        = {{Pulmonary 5-HT
        2B receptor expression in fibrotic interstitial lung diseases.}},
  url          = {{http://dx.doi.org/10.1016/j.acthis.2023.152024}},
  doi          = {{10.1016/j.acthis.2023.152024}},
  volume       = {{125}},
  year         = {{2023}},
}