Pulmonary 5-HT 2B receptor expression in fibrotic interstitial lung diseases.
(2023) In Acta Histochemica 125(3). p.1-8- Abstract
Pulmonary fibrosis is a severe condition in interstitial lung diseases (ILD) such as idiopathic pulmonary fibrosis (IPF) and systemic sclerosis-ILD, where the underlying mechanism is not well defined and with no curative treatments available. Serotonin (5-HT) signaling via the 5-HT
2B receptor has been recognized as a promising preclinical target for fibrosis. Despite this, the involvement of the 5-HT
2B receptor in fibrotic ILD is widely unexplored. This work highlights the spatial pulmonary distribution of the 5-HT
2B receptor in patients with IPF and systemic sclerosis-ILD. We show that the 5-HT
2B receptor is located in typical pathological structures e.g. honeycomb cysts and weakly in fibroblast foci. Together... (More)Pulmonary fibrosis is a severe condition in interstitial lung diseases (ILD) such as idiopathic pulmonary fibrosis (IPF) and systemic sclerosis-ILD, where the underlying mechanism is not well defined and with no curative treatments available. Serotonin (5-HT) signaling via the 5-HT
(Less)
2B receptor has been recognized as a promising preclinical target for fibrosis. Despite this, the involvement of the 5-HT
2B receptor in fibrotic ILD is widely unexplored. This work highlights the spatial pulmonary distribution of the 5-HT
2B receptor in patients with IPF and systemic sclerosis-ILD. We show that the 5-HT
2B receptor is located in typical pathological structures e.g. honeycomb cysts and weakly in fibroblast foci. Together with immunohistochemistry and immunofluorescence stainings of patient derived distal lung tissues, we identified cell targets for 5-HT
2B receptor interference in type II alveolar epithelial cells, endothelial cells and M2 macrophages. Our results emphasize the role of 5-HT
2B receptor as a target in lung fibrosis, warranting further consideration in targeting fibrotic ILDs.
- author
- Löfdahl, Anna LU ; Nybom, Annika LU ; Wigén, Jenny LU ; Dellgren, Göran ; Brunnström, Hans LU ; Wenglén, Christina LU and Westergren-Thorsson, Gunilla LU
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Acta Histochemica
- volume
- 125
- issue
- 3
- article number
- 152024
- pages
- 1 - 8
- publisher
- Elsevier
- external identifiers
-
- pmid:36958084
- scopus:85150441094
- ISSN
- 0065-1281
- DOI
- 10.1016/j.acthis.2023.152024
- language
- English
- LU publication?
- yes
- additional info
- Copyright © 2023. Published by Elsevier GmbH.
- id
- 0f2f1de9-a962-4285-8451-467fea913b30
- date added to LUP
- 2023-03-30 20:00:00
- date last changed
- 2024-09-07 09:49:48
@article{0f2f1de9-a962-4285-8451-467fea913b30, abstract = {{<p>Pulmonary fibrosis is a severe condition in interstitial lung diseases (ILD) such as idiopathic pulmonary fibrosis (IPF) and systemic sclerosis-ILD, where the underlying mechanism is not well defined and with no curative treatments available. Serotonin (5-HT) signaling via the 5-HT<br> 2B receptor has been recognized as a promising preclinical target for fibrosis. Despite this, the involvement of the 5-HT<br> 2B receptor in fibrotic ILD is widely unexplored. This work highlights the spatial pulmonary distribution of the 5-HT<br> 2B receptor in patients with IPF and systemic sclerosis-ILD. We show that the 5-HT<br> 2B receptor is located in typical pathological structures e.g. honeycomb cysts and weakly in fibroblast foci. Together with immunohistochemistry and immunofluorescence stainings of patient derived distal lung tissues, we identified cell targets for 5-HT<br> 2B receptor interference in type II alveolar epithelial cells, endothelial cells and M2 macrophages. Our results emphasize the role of 5-HT<br> 2B receptor as a target in lung fibrosis, warranting further consideration in targeting fibrotic ILDs.<br> </p>}}, author = {{Löfdahl, Anna and Nybom, Annika and Wigén, Jenny and Dellgren, Göran and Brunnström, Hans and Wenglén, Christina and Westergren-Thorsson, Gunilla}}, issn = {{0065-1281}}, language = {{eng}}, number = {{3}}, pages = {{1--8}}, publisher = {{Elsevier}}, series = {{Acta Histochemica}}, title = {{Pulmonary 5-HT 2B receptor expression in fibrotic interstitial lung diseases.}}, url = {{http://dx.doi.org/10.1016/j.acthis.2023.152024}}, doi = {{10.1016/j.acthis.2023.152024}}, volume = {{125}}, year = {{2023}}, }