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HIV-1 Transmission Patterns Within and Between Risk Groups in Coastal Kenya

Nduva, George M. LU ; Hassan, Amin S. LU ; Nazziwa, Jamirah LU ; Graham, Susan M. ; Esbjörnsson, Joakim LU and Sanders, Eduard J. (2020) In Scientific Reports 10(1).
Abstract

HIV-1 transmission patterns within and between populations at different risk of HIV-1 acquisition in Kenya are not well understood. We investigated HIV-1 transmission networks in men who have sex with men (MSM), injecting drug users (IDU), female sex workers (FSW) and heterosexuals (HET) in coastal Kenya. We used maximum-likelihood and Bayesian phylogenetics to analyse new (N = 163) and previously published (N = 495) HIV-1 polymerase sequences collected during 2005–2019. Of the 658 sequences, 131 (20%) were from MSM, 58 (9%) IDU, 109 (17%) FSW, and 360 (55%) HET. Overall, 206 (31%) sequences formed 61 clusters. Most clusters (85%) consisted of sequences from the same risk group, suggesting frequent within-group transmission. The... (More)

HIV-1 transmission patterns within and between populations at different risk of HIV-1 acquisition in Kenya are not well understood. We investigated HIV-1 transmission networks in men who have sex with men (MSM), injecting drug users (IDU), female sex workers (FSW) and heterosexuals (HET) in coastal Kenya. We used maximum-likelihood and Bayesian phylogenetics to analyse new (N = 163) and previously published (N = 495) HIV-1 polymerase sequences collected during 2005–2019. Of the 658 sequences, 131 (20%) were from MSM, 58 (9%) IDU, 109 (17%) FSW, and 360 (55%) HET. Overall, 206 (31%) sequences formed 61 clusters. Most clusters (85%) consisted of sequences from the same risk group, suggesting frequent within-group transmission. The remaining clusters were mixed between HET/MSM (7%), HET/FSW (5%), and MSM/FSW (3%) sequences. One large IDU-exclusive cluster was found, indicating an independent sub-epidemic among this group. Phylodynamic analysis of this cluster revealed a steady increase in HIV-1 infections among IDU since the estimated origin of the cluster in 1987. Our results suggest mixing between high-risk groups and heterosexual populations and could be relevant for the development of targeted HIV-1 prevention programmes in coastal Kenya.

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type
Contribution to journal
publication status
published
subject
in
Scientific Reports
volume
10
issue
1
article number
6775
publisher
Nature Publishing Group
external identifiers
  • scopus:85083774672
  • pmid:32317722
ISSN
2045-2322
DOI
10.1038/s41598-020-63731-z
language
English
LU publication?
yes
id
0fdc9fb5-907d-4e10-93c5-c324bbfe98c5
date added to LUP
2020-05-08 12:59:22
date last changed
2021-01-12 04:14:52
@article{0fdc9fb5-907d-4e10-93c5-c324bbfe98c5,
  abstract     = {<p>HIV-1 transmission patterns within and between populations at different risk of HIV-1 acquisition in Kenya are not well understood. We investigated HIV-1 transmission networks in men who have sex with men (MSM), injecting drug users (IDU), female sex workers (FSW) and heterosexuals (HET) in coastal Kenya. We used maximum-likelihood and Bayesian phylogenetics to analyse new (N = 163) and previously published (N = 495) HIV-1 polymerase sequences collected during 2005–2019. Of the 658 sequences, 131 (20%) were from MSM, 58 (9%) IDU, 109 (17%) FSW, and 360 (55%) HET. Overall, 206 (31%) sequences formed 61 clusters. Most clusters (85%) consisted of sequences from the same risk group, suggesting frequent within-group transmission. The remaining clusters were mixed between HET/MSM (7%), HET/FSW (5%), and MSM/FSW (3%) sequences. One large IDU-exclusive cluster was found, indicating an independent sub-epidemic among this group. Phylodynamic analysis of this cluster revealed a steady increase in HIV-1 infections among IDU since the estimated origin of the cluster in 1987. Our results suggest mixing between high-risk groups and heterosexual populations and could be relevant for the development of targeted HIV-1 prevention programmes in coastal Kenya.</p>},
  author       = {Nduva, George M. and Hassan, Amin S. and Nazziwa, Jamirah and Graham, Susan M. and Esbjörnsson, Joakim and Sanders, Eduard J.},
  issn         = {2045-2322},
  language     = {eng},
  number       = {1},
  publisher    = {Nature Publishing Group},
  series       = {Scientific Reports},
  title        = {HIV-1 Transmission Patterns Within and Between Risk Groups in Coastal Kenya},
  url          = {http://dx.doi.org/10.1038/s41598-020-63731-z},
  doi          = {10.1038/s41598-020-63731-z},
  volume       = {10},
  year         = {2020},
}