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High levels of HIF-2alpha highlight an immature neural crest-like neuroblastoma cell cohort located in a perivascular niche.

Pietras, Alexander LU ; Gisselsson Nord, David LU ; Øra, Ingrid LU ; Noguera, R; Beckman, Siv LU ; Navarro, S and Påhlman, Sven LU (2008) In Journal of Pathology 214(4). p.482-488
Abstract
High HIF-2alpha protein levels in the sympathetic nervous system-derived childhood tumour neuroblastoma as well as immature phenotype correlate to unfavourable outcome. Here we show that a small subset of perivascularly located, strongly HIF-2alpha-positive tumour cells (MYCN amplified) lacks expression of differentiation markers, but expresses neural crest and early sympathetic progenitor marker genes such as Notch-1, HES-1, c-Kit, dHAND, and vimentin. HIF-2alpha- and CD68-positive tumour-associated macrophages were frequently found close to the immature and HIF-2alpha-positive neuroblastoma cells and as VEGF levels are high in the perivascular niche, we hypothesize that neuroblastoma neural crest-like cells and macrophages cooperate to... (More)
High HIF-2alpha protein levels in the sympathetic nervous system-derived childhood tumour neuroblastoma as well as immature phenotype correlate to unfavourable outcome. Here we show that a small subset of perivascularly located, strongly HIF-2alpha-positive tumour cells (MYCN amplified) lacks expression of differentiation markers, but expresses neural crest and early sympathetic progenitor marker genes such as Notch-1, HES-1, c-Kit, dHAND, and vimentin. HIF-2alpha- and CD68-positive tumour-associated macrophages were frequently found close to the immature and HIF-2alpha-positive neuroblastoma cells and as VEGF levels are high in the perivascular niche, we hypothesize that neuroblastoma neural crest-like cells and macrophages cooperate to facilitate angiogenesis and thereby contribute to the aggressive neuroblastoma phenotype. Copyright (c) 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Pathology
volume
214
issue
4
pages
482 - 488
publisher
John Wiley & Sons
external identifiers
  • pmid:18189331
  • wos:000253732200010
  • scopus:40349088993
ISSN
0022-3417
DOI
10.1002/path.2304
project
CREATE Health
language
English
LU publication?
yes
id
852ba686-f424-46a0-8d2f-e74f5a0be64a (old id 1021450)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/18189331?dopt=Abstract
date added to LUP
2008-02-13 14:36:34
date last changed
2017-09-03 03:46:21
@article{852ba686-f424-46a0-8d2f-e74f5a0be64a,
  abstract     = {High HIF-2alpha protein levels in the sympathetic nervous system-derived childhood tumour neuroblastoma as well as immature phenotype correlate to unfavourable outcome. Here we show that a small subset of perivascularly located, strongly HIF-2alpha-positive tumour cells (MYCN amplified) lacks expression of differentiation markers, but expresses neural crest and early sympathetic progenitor marker genes such as Notch-1, HES-1, c-Kit, dHAND, and vimentin. HIF-2alpha- and CD68-positive tumour-associated macrophages were frequently found close to the immature and HIF-2alpha-positive neuroblastoma cells and as VEGF levels are high in the perivascular niche, we hypothesize that neuroblastoma neural crest-like cells and macrophages cooperate to facilitate angiogenesis and thereby contribute to the aggressive neuroblastoma phenotype. Copyright (c) 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.},
  author       = {Pietras, Alexander and Gisselsson Nord, David and Øra, Ingrid and Noguera, R and Beckman, Siv and Navarro, S and Påhlman, Sven},
  issn         = {0022-3417},
  language     = {eng},
  number       = {4},
  pages        = {482--488},
  publisher    = {John Wiley & Sons},
  series       = {Journal of Pathology},
  title        = {High levels of HIF-2alpha highlight an immature neural crest-like neuroblastoma cell cohort located in a perivascular niche.},
  url          = {http://dx.doi.org/10.1002/path.2304},
  volume       = {214},
  year         = {2008},
}